Zilden 50mg Tablets Sildenafil Reviews: Viagra Generic Option with an Affordable Price

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Zilden 50 mg is one of the products of the company Pascual Pharma Corp. from the Philippines. The product Zilden is a drug containing Sildenafil Citrate, which is an active pharmaceutical ingredient which helps patients relieve their symptoms of impotence or erectile dysfunction in males [1].

In some cases, there are males having difficulty when it comes to getting erections even if there is sexual stimulation. This is due to changes in the male penile vascularity due to aging and other factors (psychological, diseases, medication side effect, drug abuse, and others) [2] which cause the imbalance on the chemical signals mediating the erectile response as a whole. This chemical imbalance is the one corrected by the presence of the PDE5 inhibitors/phosphodiesterase type 5 inhibitors such as Sildenafil Citrate, which is also more famous as the component of the world-renowned drug, Viagra [3].

Zilden, since it contains the same active ingredient found in Viagra, is considered as one of the “generic Viagra” products in the market. It contains either 50 mg of the active ingredient or 100 mg and it is only available in tablet form.

About Pascual Pharma Corp

Pascual Pharma Corp is described as a Filipino pharmaceutical company which is able to provide drugs which are effective, reliable and of high quality [4]. Pascual Pharma Corp’s products are also known for their bioequivalence and their affordability, as the company made sure that their products are not only efficacious but also within the patients’ means.

The company is situated in the Philippines and was incepted some 70 years ago [5]. It was privately held then and until now, and it currently ranks the 5th top pharmaceutical company in the 20 best pharmaceutical companies in the Philippines [5].

Pascual Pharma Office

Pascual Pharma Office

Pascual manufactures medications which are pertinent to the areas of cardiology, oncology, urology, dermatology, and other generic drugs [4]. The company offers innovative formulations for its patients also in the areas of immunology needed for organ transplantation and also a unique formulation of the Vitamin B complex [6].

Concerning accreditations, the company is GMP certified and at least local FDA-accredited, although there is no information on its other international accreditations from drug-regulating bodies.

Scientific Studies on Sildenafil

Although it is known that Sildenafil Citrate was the world’s first PDE5 inhibitor for erectile dysfunction, the unearthing of other PDE5is followed shortly. Vardenafil HCl was next to Sildenafil and the drug was made more specific to PDE5, which made the drug less of a threat when it comes to vision changes. The next drug developed was Tadalafil, which was made unique due to its extended half-life—this drug can last the patients for 36 hours, unlike Sildenafil Citrate or Vardenafil which lasts only for 4 to 6 hours. Due to this, studies were continuously conducted for the determination of the patient preference for the drugs. The study of Ahn et al, “Treatment preferences in men with erectile dysfunction: an open label study in Korean men switching from sildenafil citrate to tadalafil”, studied how well would patients take the switch from Sildenafil to Tadalafil treatment for erectile dysfunction [7]. The authors included 160 Korean males who were already into Sildenafil Citrate treatment for at least 6 weeks for their impotence symptoms [7]. These males were made to continue their current Sildenafil treatment for 4 weeks and then made to enter a washout period, then were administered with Tadalafil for 8 weeks [7]. The males were evaluated for their time concerns, self-confidence when it comes to intercourse, and spontaneity [7]. At the culmination of the study, 73.7% of the males had the predilection for Tadalafil; only 26.3% of the patients who were switched to Tadalafil were able to select Sildenafil as their preferred impotence treatment [7]. This particular penchant for Tadalafil can be attributed to the patients’ abridged time concerns, although the patients all found both drugs efficacious for their impotence symptoms [7].

The study of Broderick et al in 2006, “Efficacy of tadalafil in men with erectile dysfunction naïve to phosphodiesterase 5 inhibitor therapy compared with prior responders to sildenafil citrate” compared the efficacy of Tadalafil in erectile dysfunction patients who were naïve or new to PDE5 treatments, to patients which were previously unable to respond to Sildenafil [8]. According to the authors, they sought also to test the efficacy of Tadalafil to Sildenafil non-responders, as during the time of the study, there were no papers including the effectiveness of Tadalafil in Sildenafil non-responders [8]. The study paralleled the efficacy of Tadalafil to first-time users of any PDE5 inhibitor (1,349 patients) to the drug’s efficacy to patients who were already administered with Sildenafil prior to the study (1,440 patients) [8]. These patients were evaluated in a number of parameters for sexual function and satisfaction with treatment in order to establish the efficacy of Tadalafil in the patients [8]. Based on the aggregated data, Tadalafil was able to augment the patients’ erectile function more than placebo, in both patients who were previously treated with Sildenafil and also n patients who were naïve to PDE5 inhibitor therapy [8]. However, there was no clinically significant difference noted for the naïve patients to the previous Sildenafil patients [8].

Mechanism of Sildenafil

It is known that Viagra’s Sildenafil Citrate content encourages the “return” of the proper erectile function in patients. Some patients know that it is due to the vasodilatory action of the drug, as well as its capacity to stimulate smooth muscle relaxation in the spongy tissues of the penis.

However, Sildenafil Citrate’s action is determined by its nature as a PDE5 inhibitor. PDE5 is an enzyme produced by a number of tissues in the body; it is found in the endothelium, the lungs, and is also expressed in the penile corpus cavernosum. The PDE5 enzyme is necessary for the erection cycle due to its nature of degrading the neurotransmitter cGMP after intercourse, so that the penis can return to its pre-erectile size. Men would not appreciate perpetual erections all the time, everywhere, so PDE5 is necessary to get the penis to its normal size after any sexual activity. Nonetheless, in patients with impotence, PDE5’s activity seems precipitate and it busts the erection even before it takes place. When PDE5 functions in the normal setting, its effect is invaluable, but in patients with the pathological erectile model, PDE5’s early effect is debilitating.

This is the reason why Sildenafil Citrate was invented; to suppress the action of the PDE5 in the patients with erectile dysfunction. This is so that the proper amount of cGMP may accumulate in the penile tissues, and the erection might take place. With the correct levels of cGMP (released upon sexual stimulation), the vasodilation of the arteries and the pooling of the blood in the penis can now take place, which eventually restores the erectile function in males with ED.

Zilden 50 mg Effects for Erectile Dysfunction

Zilden is indicated primarily for erectile dysfunction, although its Sildenafil Citrate content can also be used in the management of several conditions approved by the FDA. Sildenafil Citrate is also used in the treatment of benign prostatic hyperplasia’s lower urinary tract symptoms and also for the management of pulmonary hypertension. However, the Sildenafil Citrate content of Zilden is indicated specifically for erectile dysfunction and not for those other two conditions.

Since Sildenafil Citrate is an effective drug, males taking Zilden can also expect efficacy from the drug. Within an hour of taking Zilden, patients can feel the difference and they can be able to perform their sexual activities without being disappointed due to the benefits of Zilden for the patients’ erectile function.

Recommended Doses and Duration of Therapy

It is sometimes sufficient to take 50mg of Sildenafil Citrate for impotence symptoms relief; however, in some cases, patients ask for higher doses of Sildenafil due to insufficient response, and sometimes, patients also are given lower doses due to the side effects.

Zilden is a prescription drug which can’t be availed of without any doctor’s orders (as with all Sildenafil Citrate products). When prescribed, there is no telling when the treatment will end, as there is no actual recommendation for the length of Sildenafil Citrate therapy in patients.

The ideal intake for Zilden is an hour prior to intercourse, with or without food (but some say that it is better to take the drug without), and with water alone (and other liquids but not alcohol or milk or any fatty product). All Sildenafil-containing drug usually last for 4 hours.

Side Effects and Warnings

Patients usually suffer headaches, flushing, and stuffy nose with the use of Sildenafil Citrate products. However, the males taking drugs such as Zilden are also at risk for contracting vision changes such as blurred vision and blue-tinged vision, due to the effect of Sildenafil on the retina of the eyes.

Besides these, there are possible heart attack symptoms, seizures, loss of vision, loss of hearing, irregular heartbeat, chest pain, and other symptoms which may a sign of danger. Patients, at the onset of these symptoms, should seek immediate medical help, so that the condition will not progress.

Drug Interactions

Patients with ED and without any maintenance medication technically do not have something to worry about as the drugs contraindicated with ED are those for patients with impotence symptoms and are taking anti-hypertensive agents, anti-angina, and anti-retroviral medications (nitrates and protease inhibitors). However, although patients may not have concurrent diseases with maintenance drugs contraindicated with Sildenafil, patients are advised against the use of Vitamins C, D, E, and B, Fish oil, aspirin, herbal drugs, grapefruit juice, and other PDE5 inhibitor drugs, or any drugs for the amelioration of erectile function, as these drugs can interfere with Sildenafil’s action in the body.

Customer Reviews

Zilden 50mg did not have reviews from users online, which indicates that the drug may not be available in the online market. Drugs which usually have reviews from users are those which are commonly sold on Internet pharmacies and online drugstores; the dearth of client feedback for Zilden may be a sign that the product is only domestically vended in the Philippine setting.

If we are to look at the drug’s generic Sildenafil contemporaries, we can see that generic Sildenafil products are actually efficacious in the management of erectile function, even if they are technically less pricey than the branded Sildenafil product. Good reviews are available for the Indian brands, as well as the brands from other countries with their own Sildenafil products. Since Zilden is also made by a reputable company in the Philippines, we can also assume that the product is also efficacious and safe to use, although we can’t be a hundred percent sure, as we do not have any hard evidence from the clients concerning the drug’s effect.

Price, Available Forms and Dosage

Although Zilden is not available for online sale, there is a price quote for the 50 mg Zilden product on Ndrugs.com:

Zilden Price

Zilden Price

According to the price overview for Zilden from Pascual Pharma, 10 tablets of the product is sold for $1.51 only, which makes a single pill of Zilden only $0.15 each. The price for the product is overwhelmingly low, which should be great news for patients with impotence who are located in the Philippines.

The drug can only be procured by the locals of the country, as Zilden is not yet optimized for international sale, and the brand has yet to expand its reach internationally. This means no shipping for international patients wanting to try the drug who are located in the USA, Australia, or Canada. The Philippine government has not yet accredited the drug to ship outside the country, and probably due to restrictions caused by the patent protection for Viagra in several international locations.

Conclusion and Rating

Zilden 50mg is a perfect generic choice for a Sildenafil Citrate drug, but only for patients located in the Philippines. We can’t thoroughly recommend the drug, though, as Zilden has yet to acquire user reviews from clients who were able to try out the product in the past. The drug can be rated 3 out of 5 due to the seemingly good reputation of the company manufacturing the product, although the purchase of the product is still a risk.

Reference List

  1. https://medlineplus.gov/druginfo/meds/a699015.html
  2. http://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/basics/causes/con-20034244
  3. https://www.drugs.com/viagra.html
  4. http://pascualpharma.com/
  5. http://www.pascuallab.com/index.php/about-us
  6. http://pascualpharma.com/index.php/2013-05-24-10-57-11/others
  7. https://www.ncbi.nlm.nih.gov/pubmed/17968461
  8. https://www.ncbi.nlm.nih.gov/pubmed/16839323

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