Zeus Pill Sildenafil Review: Men’s Health Product with Viagra-Like Ingredients

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Zeus Pills for erectile dysfunction are pills made by Tecnimede Espana from Israel. When we say erectile dysfunction, we are pertaining to the male patients’ inability to conjure up erections necessary for intercourse. This inability of having erections is not a one-time problem for patients suffering from impotence. Men with clinical erectile dysfunction (ED) are suffering for months and years of no erectile response or erections too soft for coital activity, or also erections too fleeting for sustaining intercourse.

The products such as Zeus with the active ingredient Sildenafil Citrate are aimed at helping patients get their “good” erections back. The active ingredient Sildenafil Citrate is able to restore the lost erections in patients due to its selectivity to the enzyme PDE5, thus being dubbed as a PDE5 inhibitor [1]. Sildenafil Citrate is well-known in the market as Viagra for men’s health. This product has been around since 1998 and still available in the market today. However, due to developments in the field of pharmaceuticals and research, other versions of PDE5 inhibitors such as Vardenafil HCl and Tadalafil were developed. These are not the only PDE5 synthesized, though; there are others called Avanafil, Lodenafil, Mirodenafil, Udenafil, Zaprinast, Icariin, Dasantafil, and Benzamidenafil [2]. It is rather interesting that PDE5 inhibitors are said to be selective, while in truth, these drugs are not so selective and at times are also inhibiting several other PDEs, which causes side effects in patients.

Zeus is marketed by Tecnimede Espana in pill form alone. It does not have other formula variants, which is typical of generic Sildenafil medications in the market.

Tecnimede Group Information

Zeus’ manufacturer is the company Tecnimede, an aggregation of purely Portuguese pharmaceutical companies [3][4]. According to the company data, Tecnimede has its interests in the research, development, and manufacturing of products used in the medical industry [4]. The company was incepted in 1980, was then and until now a privately-held corporation [4]. Today, Tecnimede is about 1000 employees large and is considered one of the 500 biggest and best companies of 2016 (from Exame magazine) [4].

Tecnimede Group Main Office

Tecnimede Group Main Office

Concerning the enterprise’s output, Tecnimede currently has 100 products which the company distributes to the countries Spain, Italy, Morocco, Brazil, Asian nations, Northern and Southern American nations Middle Eastern countries, and 40 others aside from its native Portugal [3,4].

The production line of the Tecnimede Group includes other companies such as Atlantic Pharma (incepted 1984) and Atlas Pharm (inducted 2015) [5]. Atlantic Pharma is Tecnimede’s arm for its solid, liquids and suspensions, and semi-solid production and is accredited by the following: GMP, Jordan FDA, Brazil ANVISA, GCC/Gulf Cooperation Council, National Authority for Medicines and Health Products IP – INFARMED, and awarded with quality certifications such as OHSAS 18001, NP EN ISO 9001, and NP EN ISO 14001 [5]. On the other hand, Tecnimede’s Atlas Pharm subsidiary is conferred with the DMP/Direction des Médicaments et de la Pharmacie of Morocco’s Ministry of Health, GMP, as well as the IP-INFARMED [6]

Scientific Research on Sildenafil

Sildenafil Citrate is not only valuable in the treatment of erectile dysfunction for the improvement of the physiological symptoms. Due to the multi-aspect effect of erectile dysfunction in patients, treatments for erectile dysfunction or impotence are also targeted at making the patients feel better about themselves and generally improve their quality of life. The study conducted by the authors Moncada et al in 2009, “Emotional changes in men treated with sildenafil citrate for erectile dysfunction: a double-blind, placebo-controlled clinical trial” determined whether the administration of Sildenafil Citrate for their impotence symptoms can significantly ameliorate the patients’ self-esteem based on inventory questions related to relationship and self-esteem [7]. This study was conducted by the patients due to the association of impotence symptoms to the patients’ loss of self-esteem or self-worth, which can also cause devastating psychological changes or sometimes lead to clinical depression in patients. The study lasted for 14 weeks and involved 841 patients with erectile dysfunction and with concomitant comorbidities (such as hyperlipidemia, BPH, hypertension, and/or depression) who were randomized to either Sildenafil (559 patients) or placebo (282 patients) [7]. These patients were given any of the 25mg, 50mg, or 100mg Sildenafil doses, depending on their tolerance and reaction to the medication [7]. SEAR or the Self-Esteem and Relationship questionnaire was used to monitor the vicissitudes in the patients’ self-esteem as a result of the study [7]. Apart from the SEAR monitoring, IIEF (International Index of Erectile Function) changes were also noted for the patients [7]. According to Moncada et al, those patients given with Sildenafil Citrate had generally better IIEF scores than the patients who were given placebo alone [7]. Besides the good IIEF scores, the patients who were treated with Sildenafil were also with better SEAR scores, which indicated positive outcomes for their self-esteem due to the allocation of Sildenafil Citrate [7].

Apart from the iconic use of Sildenafil Citrate for the management of the dreaded impotence, the PDE5 inhibitor is also considered for its applications for the female sexual arousal disorders, due to the possible effect of Sildenafil in the PDE5 enzyme present in the female reproductive tissues. Due to this feasibility, studies were piloted by various authors, for instance, Zeinalzadeh et al, which utilized Sildenafil and compared its effect with other plausible treatments for sexual dysfunction in females (“Comparison of the Effects of Elaeagnus Angustifolia Flower Capsule and Sildenafil Citrate Tablet on Anxiety Resulting From Sexual Dysfunction in Women Referring to the Selected Clinics of Shiraz University of Medical Sciences” in 2016) [8]. Apart from Sildenafil, though, the authors tested Elaeagnus Angustifolia Flower Capsule in 125 patients with the hypoactive sexual disorder [8]. Patients were randomized to placebo, Sildenafil (50mg/4 weeks) or the flower capsule (4.5g/35 days), and were evaluated for their Female Sexual Function Index, Spielbereger’s, and their serum TSH and prolactin levels [8]. The outcome of the investigation presented that both Sildenafil and the Elaeagnus Angustifolia Flower Capsule helped ebb the anxiety levels of patients treated with both preparations [8].

Action of Sildenafil Explanation

Sildenafil Citrate’s concise effect is mainly the stimulation of the blood vessels to direct their blood flow to the penile tissues, which results in the erectile response in patients with difficulty in their erectile response. Sildenafil, as a PDE5 inhibitor, though, is not really the one signaling the blood flow to the penis; it only helps with the amplification of the signals involved in the erectile response.

The actual effect of Sildenafil Citrate is on the PDE5 enzyme. Sildenafil Citrate needs to suppress the enzyme since it is the one responsible for the flabby erections in patients, as PDE5 is the one precipitately catabolizing the cGMP in patients (cGMP is the one stimulating the vasodilation of the arteries during the erectile response). PDE5 inhibitor drugs such as Sildenafil Citrate are valuable in maintaining the balance of the chemical transmitters in order for the erectile response to continue. Sildenafil Citrate benefits the patients for about 4 hours, which means that as long as there are sufficient sexual stimuli, patients can expect augmented erections due to Sildenafil Citrate.

Zeus Pill Effects for Erectile Dysfunction

There is no doubt that the Sildenafil content of the product Zeus is more than capable of eliciting the coveted erectile response by patients with impotence symptoms. The Sildenafil content of the Zeus pill can help men with impotence to have their erections restored, which can pass off as spontaneous erections. Although there is a need to take the product continuously, the patients can seem to have a semi-normal sexual life due to the use of Zeus and similar drugs for their impotence conditions.

Recommended Doses and Duration of Therapy

The dose for Sildenafil products such as Zeus is highly variable, as there is no one-size-fits-all dosage when it comes to Sildenafil administration, so patients have doses optimized for their condition. There are males who are able to respond to the meager 25 mg dose, while there are patients who are responding to the 50mg to the 100mg dosages in patients. However, in more severe ED cases in individuals, patients require more than the 100mg dose and also are administered with other ED interventions such as counseling, behavior therapy, or penile pumps or other penile gadgets.

Side Effects and Warnings

Side effects caused by Sildenafil Citrate include vasodilatation (redness/facial flushing), head pains, dyspepsia, heartburn, indigestion, and nasopharyngitis. These side effects may be the result of Sildenafil’s inhibition of the other PDE enzymes apart from the PDE5, as the drug is not truly selective.

Although these side effects are not “big” concerns in the patients, there are peculiar side effects patients should be watching out for such as loss of vision, loss of hearing, seizures, symptoms indicative of heart attack (chest pain, numbness, nausea and vomiting), extreme allergic reaction to the drug, shortness of breath, irregular heartbeat, and other symptoms.

At the outset of any of the minor and major side effects, it is better for the patients to inform their doctors regarding the adverse events they experienced due to Sildenafil’s pharmacokinetics.

Drug Interactions

Drug interactions identified for Sildenafil Citrate includes drugs with similar effects in the patients. For instance, nitrate drugs which have similar effects to Sildenafil (hypotension-inducing, vasodilatory, etc.) nitrate drugs should be consulted with the doctors to determine whether the drugs can be taken with Sildenafil or not.

Apart from the nitrate drugs, patients are advised to take their protease inhibitors with caution, as these drugs tend to increase Sildenafil Citrate’s exposure in the body. Men who are also taking protease inhibiting drugs can have Sildenafil for their impotence symptoms, however, the dose for Sildenafil in this patient population should be no more than 25 mg.

Customer Reviews

Zeus Pill with Sildenafil is not one of the products you can buy online. There is limited data for the product which we can imply that the item is intended for local sale alone. It is sometimes hard to assume the efficacy of a certain product when no reviews exist for it, but there may be ample reasons for the lack of user evaluations for the drug.

If we’ll take a look at the company integrity of Tecnimede, we can see that the company is no ordinary enterprise; it is actually a well-certified brand with its presence in various countries in Europe and other parts of the world. It just happened that for Zeus, there was not enough marketing for the product outside the manufacturing country, or that the company intended to keep the product’s exposure within the national level alone. Though there were no client feedbacks for Zeus, we can’t assume that the product is ineffectual, as it is made by a reputable manufacturer from Europe with accreditations from various quality-evaluating institutions.

Pricing, Existing Forms, and Safe Dosage

Like there were no reviews for the brand Zeus, there were also no sellers with the product Zeus online. There is information from sources regarding the specifics of the product, but there was no Internet pharmacy with the drug in stock. This indicates that Zeus is intended for patients located in the manufacturing country alone. The only information we have on Zeus is about its availability as a 100 mg Sildenafil Citrate tablet.

Clients located in various countries cannot have Zeus delivered to their homes, even if they have the prescription for the product, due to the absence of the product online. For now, we can only recommend for buyers interested in Zeus to purchase similar drugs should Zeus be unavailable in their countries.

Conclusion and Rating

Zeus Pill is a Sildenafil Citrate drug made for impotence which is a product of the group Tecnimede, which is a European pharmaceutical company. It seems that the drug is effective due to its manufacturer’s credentials, but besides that speculation, there are no hard facts for the drug’s stats when it comes to its patient reception, price, and other aspects. However, the drug may just be a local staple and not ready for international marketing, and the producer may just be too keen regarding the prohibitions on online and international drug sale. We can only give Zeus a 2 out of 5 (for now, at least) due to its limited online exposure. But this rating is variable, as when data is already available for Zeus, we can reassess the product and give it a nobler rating.

Reference List

  1. https://en.wikipedia.org/wiki/Sildenafil
  2. https://en.wikipedia.org/wiki/PDE5_inhibitor
  3. https://www.linkedin.com/company/tecnimede
  4. http://www.tecnimede.com/pt/grupo-tecnimede/sobre
  5. http://www.tecnimede.com/pt/producao/atlantic-pharma/empresa
  6. http://www.tecnimede.com/pt/producao/atlas-pharm/empresa
  7. https://www.ncbi.nlm.nih.gov/pubmed/19796051
  8. https://www.ncbi.nlm.nih.gov/pubmed/26224722
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