Zenegra 100mg/50mg Tablets Alkem Reviews: Viagra Generic Can’t Be Taken with Alcohol

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Zenegra 100mg/50mg, the impotence drug brand from Alkem Laboratories can be one of your generic options for erectile dysfunction treatment. The “-gra” suffix of the drug implies its similarity with the famed drug Viagra, which is the world’s first and still the most famous drug for the management of chronic erectile dysfunction in patients [1].

It can be said that one of the most dreaded diseases in humankind is impotence. Males with a disorder of this kind is affected even to the psychological and social level, as the impact of having a loss of erectile function encompasses the psychological, mental, and social aspects of the patients and not only the visible physiological attributes of the individuals afflicted with the disorder [2].

Zenegra is only one of the multitude recent options males have to combat the perennial problem of erectile dysfunction. The disorder may not be totally eradicated from the population, but it can be remedied even transiently by the drugs in the family of PDE5 inhibitors, which are drugs targeted at improving the erectile function of patients by fixing the chemical transmitter imbalance in the systems of the patients affected with the disorder [3].

The main component of Zenegra is Sildenafil Citrate, which is also found in the product Viagra. Zenegra comes in packets of pills containing 50 mg of the active ingredient and also 100 mg of the component. Besides the pill/tablet form, Alkem Laboratories also makes Zenegra in capsule and spray form.

Alkem Laboratories Information

One of the multinational pharmaceutical companies situated in Mumbai is the enterprise Alkem Laboratories, which was inaugurated in 1973 [4], in a period where most of the pharma companies in India are being installed. According to its Wikipedia listing, the company has its focus on creating pharmaceutical generics, branded generics, nutraceuticals, and the essential APIs or active pharmaceutical ingredients and also has the knack for distributing these goods to countries other than where it is from (the United States, the United Kingdom, Australia, and other nations) [4].

Alkem Laboratories, Mumbai

Alkem Laboratories, Mumbai

Alkem is no stranger to the list of the top performing drug institutions in India, as in the past 12 years, Alkem Laboratories has always made it to the top 10 pharmaceutical manufacturers in the country [4]. Apart from that, Alkem is also the country’s 5th biggest pharma company and is also considered the third in terms of rapid growth and expansion [4].

The company has a portfolio of more than 700 products which are distributed in various therapeutic segments (pain management, GI, and supplements) [5]. Apart from its India market, the company supplies to 50 countries of the world (its international sales contribute to 27% of its annual revenue) and surprisingly, the company relies on its USA market as one of its key growth drivers [5]. It is impressive that Alkem Laboratories has not only earned its native India FDA approval; the company is accredited by esteemed drug regulating bodies such as the US FDA, WHO, UK’s MHRA, Brazil’s ANVISA, South Africa’s MCC, and Australia’s TGA [5].

Scientific Publications on Sildenafil

Dose optimization for Sildenafil in patients is essential, as patients tend to respond differently to the drug. Although there is a universal recommendation for Sildenafil Citrate in patients, there are studies which assessed whether the customized dosing for Sildenafil Citrate administration would benefit the patients greatly. McCullough et al, in 2006, conducted the study “A prospective study of the beneficial effects of dose optimization and customized instructions on patient satisfaction with sildenafil citrate (Viagra) for erectile dysfunction” which involved patients with ED who are naïve to any PDE5 treatment and given them customized doses for their Sildenafil intake [6]. There were two phases of the study (had a total of 8 weeks), and the patients were given flexible dosing of Sildenafil (100 mg, 50 mg, or 25 mg) [6]. The first phase of the study included giving the patients just the 50 mg of the drug, while during the second phase, the dose for the patients was adjusted to the optimum effectiveness of the product for the patients and also the product’s tolerability was considered [6]. The patients were assessed for their IIEF (International Index of Erectile Function) score and their EDITS/ Erectile Dysfunction Inventory of Treatment Satisfaction response [6]. There were 867 males who were able to complete the study and during the first phase of the study, 75% of these men were either very satisfied or somewhat satisfied with the treatment, had significant improvements from their baseline erectile function values, and also had 79% success in their intercourse attempts [6]. Concerning the results of the second phase of the study, more than half of the patients (53%) upped their Sildenafil intake to 100mg of the drug, while only 2% of the males relegated to 25mg; the rest stayed with their initial dose [6]. The dose adjustment of the patients resulted to 86% overall satisfaction with the treatment, significant improvements in the erectile function scores, and also 91% success in intercourse attempts [6]. This study proved that dose optimization in the patients can help with the increased success for Sildenafil treatment [6].

The enzyme which Sildenafil inhibits, the PDE5 enzyme, is not only found in the penile tissues and the lungs; it is also found in the platelets. Since this is the case, authors Akand et al assessed the outcome of Sildenafil administration on platelets in their paper “Effect of sildenafil on platelet function and platelet cGMP of patients with erectile dysfunction” in 2015 [7]. They intended to determine the association of platelet response and erectile function in patients who were given with 100mg of the drug Sildenafil Citrate [8]. It was determined by the authors that in patients who were responsive enough to Sildenafil Citrate, there was also a notable increase on the cGMP in platelets and also a notable diminution in the adenosine triphosphate accretion in the platelets [7]. However, in the patients who did not respond well to Sildenafil treatment, cGMP levels in the platelet were not changed and also the platelet function remained unaffected [7]. Due to this result, the authors construed that the platelets cGMP levels may also be used as a marker for erectile reaction from the patients [7].

How Sildenafil Acts

PDE5 inhibitors, regardless of the type (Sildenafil Citrate, Vardenafil Hydrochloride, and Tadalafil) have the same mechanism of action in the patients. They all inhibit the function of the chemical transmitter PDE5, which is produced by the tissues of the corpus cavernosa in the penis.

The main function of these PDE5 inhibitors, regardless of their trivial structural differences, is to foil the effect of the PDE5 enzyme on the cGMP, which is essential to the erectile function in patients. PDE5 destroys the cGMP even before a valid erection takes place, which causes the failure of the erection. Patients with erectile dysfunction often complain of having “soft” erections and erectile responses which are but fleeting and insufficient for any penetration or any continuance of a sexual activity.

Since Sildenafil is able to preclude the effect of PDE5 in the patients, the proper levels of cGMP can aggregate and cause the erection to take place.

Zenegra Effects for Erectile Dysfunction

Due to the explorative culture of the males in today’s generation in terms of drug use/abuse and alcohol/cigarette use, the cases of erectile dysfunction are higher than ever. The patients suffering from erectile dysfunction are getting younger, because of the culture of poor lifestyle habits and substance abuse (coke, marijuana, meth, and others).

Erectile dysfunction, however, can be alleviated by drugs such as Zenegra and other medications containing any PDE5 inhibitor such as Sildenafil Citrate, Vardenafil, and Tadalafil. These drugs are capable of helping the patients have a normalized erectile function in every use. Although the effect is transitory, the patients can take Sildenafil Citrate almost perpetually with minimal risk of side effects.

Recommended Doses and How Long Does it Last

Like in the studies, the patients are usually allocated with 50 mg of Sildenafil Citrate for testing, in order to determine how well the patients are going to respond to the medication [6]. However, most of the patients prefer the higher 100mg dose due to its greater effect on the patients’ erectile function. In some rare cases, though, males prefer to relegate their dose to the lower 25mg dose, as even the 50mg may be too strong for them. This is why patients need optimized doses for Sildenafil treatment, to better tailor the drug for optimum results.

On the inquiry “how long does it last?”, Sildenafil takes only a good 4 hours. For some, the 4-hour effect of the drug is more than enough. Patients should take Sildenafil/Zenegra at least 60 minutes before the planned intercourse and take the drug with water alone. No alcoholic drink should be taken with the drug, as aside from alcohol being a contributor to ED, it is also known to supplant the efficacy of Sildenafil in patients.

Sildenafil Citrate is not only used in the treatment of erectile dysfunction. The drug is also considered for several conditions such as fertility treatments for woman patients, IUI, pulmonary arterial hypertension, LUTS, and others. The dose for Sildenafil for the patients with the aforementioned condition varies depending on their need.

Side Effects and Warnings

Although the drug Sildenafil, as a PDE5 inhibitor, is said to be selective, it is determined by several studies that the drug is not as selective as it is thought to be. Besides inhibiting the PDE5 enzyme, Sildenafil is also known to impede the action of the enzymes PDE6 in the retina and PDE9, which causes side effects such as the bluish vision and other sight vicissitudes [8].

Besides the aberrations in vision, the patients can also experience dyspepsia, headaches, nasal congestion, and other side effects related to drug use. However, these side effects only last as long as the drug is in the patients’ system, so the patients can expect these adverse reactions gone after the drug has been properly excreted.

Drug Interactions

Sildenafil, as a PDE5 inhibitor poses potential interactions with other drug families. Since Sildenafil Citrate and the PDE5is are broken down by the enzyme CYP3A4 in the liver, drugs dealing with CYP3A4 are able to exert their effect on the PDE5is such as Sildenafil. These drugs include protease inhibitors such as the HIV drugs and also ketoconazole and itraconazole [8].

Apart from the protease inhibitors, the patients are also advised against the use of nitrovasodilator (or nitrate-containing drugs) [8], which are commonly utilized by patients with heart disease and hypertension. Also, users of Sildenafil Citrate should not use the product with recreational drugs in order to prevent a detrimental reaction or debilitating side effects from the drug.

Customer Reviews

India-made impotence drugs have increasing popularity in the online market for erectile dysfunction. For this reason, there are a lot of patients giving out reviews for impotence products such as Zenegra, even in the online setting.

Zenegra Testimonials

Zenegra Testimonials

One buyer from Canada, “A.E.”, shared his experience with Zenegra from Alkem Laboratories. He mentioned that he’s been consuming Zenegra consistently for 8 months and he’s never had any unpleasant experience with the product. However, there was one instance when he took Zenegra with alcohol and had terrible headaches after.

Richard Jones, one buyer from New York, also related how he’s had a chronic problem of impotence. He was advised by his friend to use Zenegra and the result was good, according to his own words.

Michael, another client from the US, stated that he’s tried herbal remedies and allopathic medicines for his impotence symptoms, but none worked. When he decided to give Zenegra a chance, he mentioned that everything went well for the first try.

Price, Dosage, and Available Forms

Since the company Alkem Laboratories is famous and because Zenegra works, there are several online drugstores which are able to sell the product online.

Zenegra Price

Zenegra Price

The cost of Zenegra 100 mg tablets is surprisingly cheap, as patients can buy as little as 4 tablets and be charged only $1.17 for each pill. Not only that, the patients can also get the product for a wee bit lower ($1.17) when they decide to procure the product in more quantities.

Zenegra Shipping

Zenegra Shipping

In the case of Alldaychemist.com, the international shipping rate for Zenegra products is a fixed $25, which is a bit pricey. However, if you are willing to use the promoted payment options such as wire transfer, money orders, e-checks, or personal checks, the store is willing to subsidize the shipping cost. Promotional offers from Internet stores are sometimes available and can help out patients with financing concerns.

Conclusion and Rating

Zenegra 100mg is a product from the renowned Indian multinational company, Alkem Laboratories, which is known for its quality products and its impressive accreditations. Although Zenegra hasn’t yet been approved by the US FDA, we can grant the product a 4 out of 5 for being a reliable drug for impotence. Its economical price is also a big bonus, as it ranks as one of the cheapest erectile dysfunction products from Indian companies online. You can definitely give Zenegra a try, but only when you are legally prescribed to procure a Sildenafil drug.

Reference List

  1. http://www.webmd.com/erectile-dysfunction/guide/cialis-levitra-staxyn-viagra-treat-ed#1
  2. http://www.medscape.com/viewarticle/551562_4
  3. https://en.wikipedia.org/wiki/PDE5_inhibitor
  4. https://en.wikipedia.org/wiki/Alkem_Laboratories
  5. http://www.alkemlabs.com/overview
  6. https://www.ncbi.nlm.nih.gov/pubmed/17011374
  7. https://www.ncbi.nlm.nih.gov/pubmed/25486996
  8. https://en.wikipedia.org/wiki/PDE5_inhibitor
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