Zeagra 100mg/50mg Tablets Zee Lab Reviews: Cheap Price Gets you a Poor Quality Viagra!

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Zeagra 50/100 mg is the most effective and popular medicine to get rid of male impotence. The composition of this drug is Sildenafil citrate which is a universal formula for treating male erectile dysfunction and pulmonary hypertension. It belongs to the group of phosphodiesterase inhibitors. Zeagra is available in capsular, gel, spray as well as in tablet form. Zeagra tablets are taken on a daily basis at a fixed time to treat issues of erectile dysfunction and can be taken with or without food. It is inadvisable to individuals with blood pressure and heart problems as Zeagra stimulates penile blood flow. Some side effects like headache nausea, vomiting, and sweating can be seen only when taken in high doses. Zeagra is totally a safe drug with no steroidal effects but like every other drug, it has its own drug interactions, therefore, a consultation with a physician is a must before starting any kind of sildenafil citrate therapy.

About Zee Lab

Zee Lab Main Office

Zee Lab Main Office

Zee laboratories were first manufactured in 1994. Its first manufacturing unit was established in Karnal city in the state of Haryana in India. The company started its second unit in 2005. Almost 700 individuals are involved in working with this company. Zee laboratories Ltd is a $75 million group, maintaining its proficiency towards excellence. The company is an umbrella to many branded and generic products. Zee labs are associated with Lanark labs, Kloster life sciences, Axyzen life sciences, Bio next, and Zee drugs. Personal care portfolio brings world-class products with clearly differentiated benefits to quality-seeking consumers. Their Personal Care Portfolio supplies customers worldwide with beauty and health products to promote health, beauty, vitality, intimacy and overall quality lifestyle. Zee laboratories have obtained 13 million USD in 2016. The company got its USFDA approval for its 70% of products while rests of its products are still in the process of getting approval. [1]

Scientific Studies on Sildenafil

Axel Kleinsasser et al in his research “Sildenafil modulates hemodynamic and pulmonary gas exchange” said that sildenafil effects on the hemodynamic and pulmonary exchange of gasses are unknown. So to further investigate the effect of Sildenafil on the gaseous exchange he took 24 anesthetized pigs and divided them into four groups i.e. low group, high group, control group and normal group each group consist of six animals. Group low received the dose of 25mg, group high received 100 mg; group normal received 50 mg through gastric tubes. After the time lapse of 30 min, 60 min and 90 min inert gas and hemodynamic measurement were taken to evaluate the dose which has an effect on cardiac and pulmonary function. There was remarkable increase in intrapulmonary shunt flow (readings were max amp 4.4+   0.3 to 11.9 + 0.5 %; mean + SEM) and decreased in pao2. Increase in cardiac index (measurements were 142+ 10 to 196 + 13 ml kg-1, mean   + SEM) is also seen whereas the mean arterial pressure was decreased (max amp, 16+ 1.6 to 14+ 1.8, mean SEM) in both cardiac and pulmonary arterial pressure in high doses. Hence the result showed that there was no notable difference is seen in the above-mentioned groups. Sildenafil is orally active drug with phosphodiesterase inhibitors (the enzyme that hydrolyzes guanosine 3’5′ –cyclic monophosphate (cGMP) which increases cardiac output where the partial pressure of gasses decreased after the ingestion of 50 and 100 mg with an increase in pulmonary shunt flow and chloride ions. [2]

Gianfranco Piccirillo et al in his research “Effects of Sildenafil on cardiac repolarization and on autonomic control in subjects with chronic heart failure” said that the case of sudden death has been reported in men using Sildenafil therapy, with congestive heart failure. To support his statement he conducted a research to further investigate the death prevalence of chronic heart failure with Sildenafil therapy or whether this drug has any effect on CHF patients or not. He took 10 men with dilated cardiomyopathy and 10 with control subject and a control group. After administration of Sildenafil citrate 50 mg sublingually, after that, he measured QT-RR slope, index of QT variability (QTVI), QT dispersion and analyzed systolic blood pressure and spectral power of RR. No attempt of physical activity was done. So the measurements of the result showed an increase in heart rate and decreased in systolic blood pressure. Increase in QT-RR and QTVI (from -0.45 +0-07 to -0.27 + 0.07; <.001) in CHF subjects was visible but in control group QTVI increases from -1.20 + 0.08 to – 0.78 + .014; p < .001. In CHF the ratio increases from low frequency to a high frequency which, expressed in normal units, is p<0.05. Therefore the measurement showed that no change is observed in QT interval and dispersion. Overall view of the result showed that individuals with CHF may have increased in sympathetic modulation and reduction of vigil modulation. The changes in the autonomic system may provoke some changes in QT readings and both changes may cause arrhythmias. As Sildenafil is a lethal killer to potent sexual problems so it has no effect on QT interval and dispersion. [3]

Sildenafil Action Explained

Sildenafil, a lethal killer to potent sexual problems, must be taken prior to sexual engagement. It stimulates the activity of prostate gland. It consists of cGMP-specific phosphodiesterase type 5 deterioration of cGMP in corpus cavernosum. It relaxes the penile smooth muscle of the prostate and increases blood flow which in a result causes the erection. Sildenafil molecular structure resembles cGMP and acts as a binding agent so it helps in the release of more cGMP and better stimulation. [4]

Zeagra Effects for Erectile Dysfunction

The effect of Zeagra is just like Viagra. It is used to stimulate penile erection for a long time in men’s. The drug keeps men happy and their partners satisfied by increasing the living and quality standard of their life. It is sometimes also used to treat pulmonary hypertension in both males and females

Recommendation for Doses and Scope of Therapy

Zeagra can be taken with or without food. The recommended dose is one tablet per day on a fixed time orally. Mostly 50 mg is given to early diagnosed patients as per recommendations of the doctor. Users must avoid the use of any other sildenafil drug with Zeagra. Use of alcohol is highly prohibited as it reduces the effectiveness of the drug and provokes the elimination of Zeagra which may lead to some serious side effects. Do not use this drug with a high fatty meal. The duration of therapy depends on the condition of the individuals. [5]

Side Effects and Warnings

Users are advised to take Sildenafil exactly as their doctor had prescribed them, check with your doctor or pharmacist if you are not sure. It gives sexual benefits in your healthy lifestyle. Do not use this medicine if you are allergic to the ingredients of this medicine if you have kidney or liver problem if you have severe hyper or hypotension. Do not use this medicine or if you are a breastfeeding mother, if you are recently diagnosed with any heart problem, if you drink alcohol or grape juice.

It is well-tolerated drug with a low incidence of side effects most side effects observed were mild to moderate in severity which may include insomnia, low blood volumes, sweating, cough, edema, headaches, flushing of skin, seizure, hearing problems, visual impairments, muscle weakness, nausea, pain diarrhea, and GIT reflux if Sildenafil is taken in high dosage. If any of above applies to you, talk to your doctor before you take any further medication. [6]

Drug Interactions

Adempas, amyl nitrite, bidil, boceprevir, cyanide antidote kit, deponit, dilatrate-SR, go nitro, hydralazine have major drug interactions with sildenafil. Sildenafil should be taken before one hour or after two hours of the above-mentioned drugs. No drug is to be used in collaboration with sildenafil. Humatrope, jumex, kuvan, korlym, itraconazole, isoptine SR, juxatapid, iorcaserin, ketek pak, luvox, luminal, lopinavir, lexiva, luminal, raxar, phrenilin, oxcarbazepine, onmel, posicor, phrenilin, prazosin, pecaps, primidone, procardia, prezista, primidone, qoliana, agenerase, rifampin, quadrinal, protropin, raxar, ritonavir, rimactane, somatropin, somatrem, solfoton, sodium nitride, spastrin, st.john’s wort, sustiva, sprycel, Sulfimycin, tev -tropin, tracleer, tiazac, terazosin, tybost, triad, trental, tykerb, tuinal, urelief plus will have some minor drug interactions.

Aspirin, fish oil Omeprazole, Cymbalta, flomax, nexium have no or minimum drug interaction with sildenafil. The use of alcohol may reduce the efficacy of the drug. [7]

Customer Reviews

No customer reviews were found online to justify the claims of Zeagra’s manufacturer. Drugs, not having any customer feedback, are not recommended to be used because they might be ineffective or hazardous for the health. Therefore, Zeagra should never be used as a first-line therapy by customers. Interested people should look for an alternative drug with same active ingredient but with customer reviews proving its reliability and efficacy.

Price, Available Forms, and Dosage

Zeagra is available for purchase at different online pharmacies.

Zeagra Prices

Zeagra Prices

The drug can be obtained in different packs and the unit price of Zeagra is kept stable at 1 US Dollar.

Zeagra Shipping Cost

Zeagra Shipping Cost

Shipping charges are fixed at 25 USD to all parts of the world including America, Canada and Australia [8].

Zeagra is offered in the form of tablets containing sildenafil. The initial dose of sildenafil at the start of therapy is 50 mg which is later adjusted as per the tolerability of a customer.

Conclusion and Rating

The absence of customer reviews for Zeagra does not make me recommend Zeagra as a brand to rely on for treating any ED issues. Keep in touch with your doctor to learn the effectiveness of Zeagra on your body. I will rate this drug 3 out of 5 as the price is average and its manufacturer is well-known. International shipping is available, so it is not hard for customers to get Zeagra if its usage is approved by a primary care provider.

Reference List

  1. http://www.zeelab.co.in/at_glance.html
  2. http://www.atsjournals.org/doi/abs/10.1164/ajrccm.163.2.2003021
  3. https://academic.oup.com/cardiovascres/article/55/2/290/355557/Effects-of-sildenafil-on-cardiac-repolarization
  4. http://patient.info/medicine/sildenafil-for-erectile-dysfunction-nipatra-viagra-vizarsin
  5. https://www.evidence.nhs.uk/formulary/bnf/current/7-obstetrics-gynaecology-and-urinary-tract-disorders/74-drugs-for-genito-urinary-disorders/745-drugs-for-erectile-dysfunction/phosphodiesterase-type-5-inhibitors/sildenafil
  6. http://www.medicinenet.com/sildenafil/article.htm
  7. http://www.everydayhealth.com/drugs/Viagra
  8. http://buybestmedicine.com/ZEAGRA-GENERIC-VIAGRA.asp
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