Vistagra 100mg/50mg Tablet Cadila Review: Price vs Benefits Erectile Dysfunction Brand Ratio

Image result for Vistagra

Vistagra 100mg/50mg adds to the growing list of the generic pharmaceutical products intended for the treatment of the condition erectile dysfunction. This may be due to the inevitability of erectile dysfunction in male patients, especially now that the younger population is somewhat indulged in a great number of devastating life habits such as chronic drug abuse, smoking, and alcoholism [1]. Also, the rise of the number of generic impotence products may be expected as the patent expiration for the world famous erectile dysfunction drug Viagra is nearing its end in a few years [2].

The product Vistagra contains the active pharmaceutical ingredient Sildenafil Citrate, which has been proven in the past years as exceedingly potent for the management of erectile dysfunction in patients. Sildenafil Citrate is efficacious, as it deals with the chemical signals involved in the erectile response in patients. It acts on the PDE5 enzyme and suppresses its action, in order for the vasodilation and the smooth muscle cell relaxation to take place in the penile tissues [3].

However, the benefits of Sildenafil Citrate contained in Vistagra actually go beyond erectile dysfunction treatment alone; the drug has its effectiveness in several medical considerations such as pulmonary arterial hypertension in pediatric patients and in adults, male BPH and urinary retention, memory enhancement, female fertility treatments, and for female sexual disorders.

Vistagra, the product from Cadila Pharmaceuticals is a Sildenafil Citrate product containing either 100mg or 50mg of Sildenafil. It is available in the traditional tablet form only, unlike the other Sildenafil products which can be bought in other exciting forms such as jellies or effervescent tablets.

About Cadila Pharmaceuticals

There is quite a number of pharmaceutical companies in India, due to the country’s fame when it comes to the low cost of labor and other factors beneficial for local and international drug companies. The company, Cadila Pharmaceuticals is one of the brands which are situated in India (Ankleshwar). It is said that Cadila is recognized as one of the biggest private pharmaceutical companies in the country [4] and it has been in the business for over 60 years [4].

Image result for Cadila Pharmaceuticals Ltd.

The focal points of Cadila’s pharmaceutical product manufacturing are the areas of gastrointestinal, pain relief, cardiovascular, immunological drugs, respiratory medicine, diabetes, and more [4]. Cadila is also concerned in the synthesis of active pharmaceutical ingredients or APIs, which are the raw materials of pharmaceutical products and medicinal formulations [5]. Apart from API manufacturing, the company’s strong suit is research and development, which helps Cadila in the improvement of the products and its endeavors in biotechnology, phytochemistry, and plant tissue culture [5].

Cadila Healthcare is not simply a manufacturer, it is also a well-accredited business entity when it comes to its products. According to the data on Cadila’s website, the enterprise was bestowed with accreditations such as the US FDA approval, European Directorate of Quality Medicine certification, Australia Therapeutic Goods Administration approval, WHO certification, and AIFA/Agenzia Italiana del Farmaco Italy. Apart from these big-name certifications, Cadila’s plants are also awarded the ISO 9001 and ISO 14001 certifications, which are a proof of the company’s quality manufacturing practices.

Scientific Studies on Sildenafil

Due to the short-term effect of Sildenafil Citrate in patients with erectile dysfunction, Tadalafil is often considered as a replacement for the drug Sildenafil, especially for patients with pulmonary arterial hypertension, as the patients need a drug with a more lasting effect. Due to the discovery of the longer enduring Tadalafil, researchers considered the switch from Sildenafil Citrate to Tadalafil. The paper by Shlobin et al in 2012, “Transition of PH Patients from Sildenafil to Tadalafil: Feasibility and Practical Considerations” tested whether patients can indeed switch from the use of Sildenafil to Tadalafil for their PAH condition [6]. The main measure of the success of the transition is the tolerance of the patients to Tadalafil without complications. In order to determine that, the 35 subjects of the study were made to endure the 6MWD or 6-minute walk test distance to evaluate the success of the drug change [6]. Based on the switching outcome, 85.7% of the patients were able to transition safely to Tadalafil, although a certain percentage of the patients (14.3%) did not take Tadalafil well and exhibited exacerbation of their clinical condition [6]. It Although there were patients who weren’t able to shift to Tadalafil properly, the authors agreed that the switch to Tadalafil was overall successful; those who weren’t able to transition to Tadalafil well were those who were taking higher doses of Sildenafil for their condition [6].

Apart from pulmonary hypertension, erectile dysfunction is one of the FDA-approved conditions where Sildenafil Citrate is indicated for. Tadalafil, too, was created with a similar function as Sildenafil, so the drug is also being utilized for erectile dysfunction. The study of Dean et al determined the difference of the psychological results of the use of Sildenafil and Tadalafil for erectile dysfunction (“Psychosocial outcomes and drug attributes affecting treatment choice in men receiving sildenafil citrate and tadalafil for the treatment of erectile dysfunction: results of a multicenter, randomized, open-label, crossover study” in 2006) [7]. 364 patients were involved in the study and were randomized to a 12-week Sildenafil treatment (50 mg or 100 mg) then another 12 weeks of Tadalafil (10 mg or 20 mg) treatment, or the reverse of the cycle [7]. The patients were evaluated using PAIRS (Psychological and Interpersonal Relationship Scales) and the Drug Attribute Questionnaire in order to assess the preference of the patients for the drugs [7]. There were 291 patients who were able to complete the study and 71% of the patients preferred the use of Tadalafil over Sildenafil Citrate, although both drugs were deemed effective [7]. Based on the study’s outcome, the patients were more confident when using Tadalafil, the sexual activity was more spontaneous, and they had fewer time concerns [7]. Also, another factor affecting the patients’ preference to the drug is the lasting effect of Tadalafil in the patients [7]. The study culminated with the patients preferring Tadalafil over Sildenafil Citrate due to the improved psychosocial outcomes of the patients when taking the drug, compared with their experience with Sildenafil [7].

Sildenafil Action Explained

Sildenafil Citrate’s efficacy can be pinpointed to its action as a PDE5 inhibitor. Being a drug classified in that category, Sildenafil Citrate prevents the mechanism of PDE5 enzyme as the enzyme is linked to the destruction of the erection process in the patients. PDE5 destroys the cGMP, the main mediator of the vasodilation in the male penis. Sildenafil Citrate prevents the deterioration of the cGMP before the appropriate time, which helps the correct amounts of the cGMP to accumulate in the penile tissues. Given the correct levels of the cGMP in the penile vascularity, the cGMP can encourage increased blood flow to the area, leading the patients to have an erection although there is damage in their hydraulic erection system. Sildenafil Citrate enables the patients to have their erections when using Sildenafil Citrate, for about 4 hours, as the drug functions in the body for more or less 4 hours.

Vistagra Benefits for ED (Erectile Dysfunction)

Vistagra benefits the patients by enabling them to restore their erectile function by taking Sildenafil Citrate as medication for their impotence problem. Vistagra and other Sildenafil Citrate products do not offer a permanent solution for impotence, but patients can expect a transient improvement in their condition when using Vistagra for their erection problems.

Suitable Doses and Duration of Therapy

Patients are often prescribed with Sildenafil in either 50mg or 100mg, depending on their need for the drug. There are patients who can take the 50mg dose and also experience a good effect out of the drug, while others need to titrate to 100mg of Sildenafil for their condition.

The intake of Sildenafil products is limited to only one dose per day (for erectile dysfunction) and only as needed. The ideal consumption of the drug should be done at least an hour before the sexual activity, in order for the patients to maximize the effect of the drug.

Side Effects and Warnings

Some patients tend to suffer side effects due to the consumption of Sildenafil products. There are males who experience headaches, flushing, and vision difficulties, due to Sildenafil’s effect on other bodily tissues [8]. However, these events soon cancel out as the patients get used to the intake of Sildenafil. In some cases, the side effects also wane as the drug is metabolized by the body.

Patients with other health considerations are advised to consult with a physician first, due to possible complications brought about by the use of Sildenafil products. For instance, patients with liver disease, various cancers, kidney disease, and heart disease are advised to have close monitoring for their Sildenafil intake.

Drug Interactions

Patients taking Vistagra and other Sildenafil products are advised to stay away from certain medicinal products due to the possible negative outcome of the administration of Sildenafil and some types of drugs. For instance, drugs which tend to lower the blood pressure such as anti-hypertensives, nitrate drugs, and drugs for chest pain are advised to be veered away from the patients, as Sildenafil already has a hypotensive effect on the patients [8].

Apart from these drugs, patients are also advised to stay away from protease inhibitors and drugs for fungal infections, as these drugs are able to increase Sildenafil’s exposure in the bloodstream, which is possibly toxic for the patients [8].

Customer Reviews

There were several client feedbacks available for Vistagra and they were positive regarding the drug’s efficacy. On patient, Vistali, said that without the drug, he can’t function sexually. He thought at first that it feels offensive that as a man, he can’t perform his sexual duties. But he ended his comment with “so what”, which means he finally accepted that he was in need of medical intervention for his erectile problem (Vistagra).

Vistagra Customer Experience

Vistagra Customer Experience

Nicholas also gave Vistagra 5 out of 5 stars for the product and he did so due to the drug’s “lack of side effects”. According to him, there were drugs which can give headaches, but during his use of Vistagra, he did not experience side reactions of the sort. Although patients are already warned of the side effects of the drug, patients still look for impotence medications which can possibly limit the presence of side interactions. We can say that Nicholas had it good with Vistagra, since there is also an advisory for the side effects of the drug, but he was able to steer away from them.

Vistagra Customer Reports

Vistagra Customer Reports

Vadim, another client, mentioned that Vistagra was the most effective amongst all the drugs he’s tried for impotence.

Nicholas, a 40-year old client, also rated the drug with 5 out of 5 stars. Nicholas cited that Vistagra “fulfills at 100”, which meant effectiveness on the drug’s part. However, his only complaint was that the drug takes about an hour to take effect, which is rather standard for Sildenafil medications.

Price, Available Forms, and Dosage

Vistagra is available in 100mg and 50mg forms, which are the standard dosage forms for any Sildenafil medications. A few online stores have Vistagra, so it is possible for buyers to procure the drug via ordering thru the web.

Vistagra Prices

Vistagra Prices

The minimum charge for the sale of Vistagra is about $3.63 per pill, although the price tends to thin down a bit when patients try to purchase larger orders from the drug. Concerning the shipping rate, the patients of Internationaldrugmart.com can have their products shipped for a minimum fee of $12.99, although the store offers subsidized shipping rates for its buyers (for a minimum purchase).

Vistagra Shipping Cost

Vistagra Shipping Cost

Currently, there is no news of the ban of Vistagra online or in several locations, so we can assume that it is possible to procure the product online without difficulty. However, there are still countries with restrictions on the distribution of generic Viagra products due to patent laws, so buyers have to take note of the locations where their orders may be considered illegal.

Conclusion and Verdict

Vistagra 100mg/50mg provides yet another alternative for an impotence drug in the market for erectile dysfunction products. The drug has good reviews, which is also good for the product since it is seldom that buyers have reviews for seemingly novel erectile dysfunction drugs in the market. The maker of the drug, Cadila, is also US FDA accredited, so patients can rely on the drug to be high quality and effective. We can give Vistagra 4 out of 5 since it gained accolades from its buyers and also due to its fair pricing in the market. Vistagra is recommendable for patients who are looking for drugs to replace their expensive ED drugs, as Vistagra is economically priced and yet effective. However, you should only use Vistagra when directed by the doctors, as self-medicating on any prescription drug is a dangerous practice.

References

  1. Easyhealthoptions.com: Sexual Performance After Drug Abuse, What’s The Story? Obtained from: http://easyhealthoptions.com/sex-after-drug-abuse-whats-the-story/
  2. Cbsnews.com: Viagra to go generic in 2017 according to Pfizer agreement. Obtained from: http://www.cbsnews.com/news/viagra-to-go-generic-in-2017-according-to-pfizer-agreement/
  3. Rxlist.com: Viagra. Obtained from: http://www.rxlist.com/viagra-drug/clinical-pharmacology.htm
  4. Cadilapharma.com: About Us. Obtained from: http://cadilapharma.com/about-us/
  5. Cadilapharma.com: API Manufacturer. Obtained from: http://cadilapharma.com/products/api/
  6. Shlobin OA, Brown AW, Weir N, Ahmad S, Lemma M, Nathan SD. Transition of PH patients from sildenafil to tadalafil: feasibility and practical considerations. Lung. 2012 Oct 1; 190(5):573-8. Obtained from: https://link.springer.com/article/10.1007/s00408-012-9408-6
  7. Dean J, Gentile V, Hackett GI, Pirozzi-Farina F,, Zhao Y, Rosen RC, Beardsworth A, Warner MR. Psychosocial outcomes and drug attributes affecting treatment choice in men receiving sildenafil citrate and tadalafil for the treatment of erectile dysfunction: results of a multicenter, randomized, open-label, crossover study. The journal of sexual medicine. 2006 Jul; 3(4):650-61. Obtained from: http://europepmc.org/abstract/med/16839321
  8. En.wikipedia.org: PDE5 inhibitor. Obtained from: https://en.wikipedia.org/wiki/PDE5_inhibitor
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