Tadalista Super Active Review – Safe Generic Option for Erectile Dysfunction

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Tadalista Super Active is one of the products the company Fortune Healthcare (India) manufactures for its Tadalista product line. Tadalista Super Active is one generic medication which contains the active pharmaceutical ingredient Tadalafil, which is an effective agent for impotence treatment. Impotence is technically called erectile dysfunction, which is a condition where male patients are unable to have erections and retain them even when sexually stimulated [1]. Although male impotence is an enormous for the affected males, erectile dysfunction is often treatable and manageable by oral medication, therapy, and in more severe, treatment-unresponsive cases, surgery.

There are several factors affecting male impotence and one of the risks associated with contracting the disease is age, although age is not the sole factor for erectile dysfunction development [2]. Younger males (40 and below) are also prone to contracting erectile dysfunction and in some cases, the young men diagnosed with ED have more severe forms of impotence as theirs came from drug abuse, chronic smoking, and alcoholism, and sometimes from medication side effects [3].

Fortune Healthcare: Manufacturer Profile

The Fortune Healthcare enterprise is responsible for the production of Tadalista, one of the commonly sold erectile dysfunction products on the internet. Tadalista products are not the only one manufactured by the pharmaceutical company; aside from Tadalista, there are more goods from the company such as veterinary products, anti-tuberculosis medication, cardiovascular medicine, men’s health meds (such as Fildena and Filagra), and antibiotics [4].

Fortune Healthcare is located in Vadodara, Gujarat, in India [4]. Its facility there is WHO-Good Manufacturing Practices Certified and also ISO 9001:2000 accredited. The corporation spoke of having a turnover of $150 M and 300 products under its name. Apart from being one of the local contributors to the Indian pharmaceutical industry, Fortune Healthcare seeks to expand its reach to global heights, as it began to saturate Asia. Its initial move was to its 40-product approval in the Philippines, and the company plans to have its products exported to other Asian countries as well [5].

Scientific Studies for Tadalafil

During the past years, the common subject for clinical studies are the individual PDE5 (Phosphodiesterase Type 5) inhibitors, but only a few researches studied the use of two PDE5 inhibitors concurrently for the long-term management of male impotence (erectile dysfunction). The study by Cui et al “Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction” in 2015 is different among the other studies as the clinical study evaluated the efficacy and the safety profile of the use of Sildenafil and Tadalafil at the same time as treatment for early stages of erectile dysfunction in patients [6]. The study took in 180 patients diagnosed with ED (180) and divided them into 2 groups; one group was given a daily dose of 5 mg Tadalafil, while the other group was given 5 mg of Tadalafil plus a dose of 50 mg Sildenafil to be administered on-demand. The safety of the intake of the medications was gauged by the patients’ tolerance of the drug and the appearance of side effects, while the efficacy of the treatments was assessed using IIEF-5 (International Index of Erectile Function) and SEP (Sexual Encounter Profile) parameters [6]. The result of the study indicated greater improvements in the IIEF-5 scores of the patients who were treated with both Tadalafil and on-demand Sildenafil 50 mg as compared with the results of the Tadalafil singular treatment. For the IIEF Question 3 responses from patients with severe ED, however, the development was only noted for the patients taking combination treatment. The SEP scores of the patients were significantly higher for the combined treatments than for the singular Tadalafil administration [6]. There were no determined differences for the side effects, though. All in all, the researchers concluded that the combination therapy of Tadalafil daily with an on-demand dose of Sildenafil is able to help patients have their erectile function restored, even the ones with the severe cases [6].

Not only was Tadalafil used in the restoration of patient erectile function; it is also considered as a preventive agent for erectile dysfunction in patients. The study of Pisansky et al, “Tadalafil for prevention of erectile dysfunction after radiotherapy for prostate cancer: the Radiation Therapy Oncology Group [0831] randomized clinical trial” in 2014 determined whether Tadalafil is able to preserve the erectile function of patients who were treated with radiotherapy for their prostate cancer [7]. 242 patients scheduled to receive radiation therapy for prostate cancer and with intact erectile function were divided into 2 groups and were given either 5 mg of Tadalafil or placebo for 24 weeks starting their procedure (external radiotherapy: 63% brachytherapy: 37%) [7]. The patients were evaluated using the IIEF and the Sexual Adjustment Questionnaire, and Locke Marital Adjustment Test [7]. The result of the study indicated that there was no significant improvement in erectile function noted in patients taking Tadalafil while undergoing radiation therapy [7]. The patients and their partners did not observe any substantial difference in terms of sexual satisfaction and their marital adjustment with the intake of Tadalafil [7].

Mechanism of Action of Tadalafil

Tadalafil is one of the PDE5 inhibitors which are the main drugs-of-choice when it comes to treating patients with impotence. Tadalafil is the latest of the PDE5 inhibitor drugs, which means that it is somewhat more improved than its predecessors.

As a Phosphodiesterase Type-5 inhibitor, Tadalafil is able to subdue the effect of the enzyme PDE5 in its destruction of the cGMP essential in the erectile function. The prevention of Tadalafil in destroying cGMP (cyclic guanosine monophosphate) is the reason why the patients are able to have their erectile function back again. When cGMP is destroyed, there would be no command for the blood vessels to vasodilate or for the smooth muscle cells to relax, which both lead to an erection in patients. Since Tadalafil inhibits the PDE5 action, patients are able to maintain the proper cGMP levels in the corpus cavernosum, which ensures that the erectile response will work properly upon sexual stimulation.

Tadalista Super Active Effects for Erectile Dysfunction

Although as a PDE5 inhibitor, Tadalafil is known to improve the condition of patients with Pulmonary Arterial Hypertension (PAH) and the lower urinary tract symptoms associated with prostate enlargement, Tadalafil is better known as a treatment for erectile failure/dysfunction due to its extended effect of until 36 hours in patients taking the medication. Men suffering from impotence have improved erectile response as a result of the Tadalafil intake; and because there is a daily dose option for patients too, ED-affected individuals are able to live normal sex lives with Tadalafil use.

Recommended Dosage and Duration of Therapy

Tadalafil products are taken as needed for the variants with the strengths of 10 mg and above, while the lower doses (2.5 mg and the 5 mg types) are consumed on a daily basis. Tadalafil is superior to the two PDE5 inhibitors due to its lack of limitations when it comes to intake; Tadalafil products, regardless of brand, may be taken by the consumers with or without food and with or without alcohol intake, as Tadalafil has been optimized to not interact with food or alcohol in the body.

Since there is still no cure for erectile dysfunction, Tadalafil has to be taken indefinitely, or until the doctor tells the patients to discontinue the medication. No long-term damages have been ascertained for Tadalafil use, so for now, the patients can rest assured that their chronic, guided Tadalafil use will not lead to permanent endothelial tissue damage or to permanent reproductive system alterations.

Side Effects and Warnings

There are quite a few considerations for the candidates for Tadalafil prescription. Although erectile dysfunction must be treated in patients having the condition, there are certain instances determined which are not viable for PDE5 inhibitor treatment or Tadalafil administration, due to the greater risks entailed. For instance, patients with any form of liver damage, liver disease, or metabolic problems, should under no circumstances take Tadalafil or any other PDE5 treatment for impotence, due to the possibility of toxicity. Since the hepatic function is damaged in these patients, the by-products of Tadalafil metabolism are not properly excreted from the system, which can cause adverse effects to the patients. Furthermore, patients with renal or kidney disease and cancers of all sorts are also barred from taking Tadalafil products due to the possible damage the drug can bring to patients with these medical conditions.

Relating to the side effects, the common treatment side effects documented for Tadalafil use are facial flushing, headaches, dyspepsia, dizziness, back pain and blurred vision. These results are impermanent, and the users can expect these adverse interactions to diminish over time and over repeated Tadalafil use.

Drug Interactions

Although there are a considerable number of drugs interacting with products containing Tadalafil as an active pharmaceutical ingredient, the Tadalafil interaction with nitrates is the most ill-advised in patients. The patients are restricted to the health professionals to be administered with both nitrate-composed medications and the PDE5 inhibitor meds, since both the products are able to lower the blood pressure of patients, even in critical levels. Nitrates are commonly found in products such as heart medication, hypertension meds, and even in recreational drugs. As a precaution, patients should not take any other Rx medication without the advice of the physicians in order to avoid potentially hazardous drug interactions as a result of Tadalafil intake and other prescription meds.

Customer Reviews

Tadalista Super Active is a product in soft gel form so it is generally intended to work faster than the usual/traditional hard pill types of Tadalista products. Here are some of the user feedbacks for Tadalista Super Active use:

Apparently, the buyers loved Tadalista Super Active, as they rated the soft gel variant of Tadalista excellently (5 out of the 5 possible stars). Patrick, one user, mentioned that he was “completely satisfied” with the medication. It was interesting that he brought up that he was able to experience the drug’s effect for about 3 days, especially when it was taken on a regular basis. The effect was not the only one he appreciated as he lauded the drug even for its affordability in comparison with the brand name treatment.

Rod Harper, another satisfied client, rated the product 5/5 as according to him, Tadalista Super Active is capable of working rapidly upon ingestion and lasts for hours. Rod even recommends the product to other consumers with the same erectile concerns.

Nanas, on the other hand, is on the same page with the other consumers as he graded Tadalista Super Active with 5 out of 5 and cited that the drug “is the best product”. It seems that buyers are content with their purchases of the Tadalista product, which is generally a good indication of quality. Although these reviews do not represent the entirety of the consumers worldwide, these should give other clients a good idea of what to expect when taking Tadalista Super Active.

Price, Forms and Tadalista Super Active Dosage

Tadalista products are widely accessible on the Internet, but there are only several vendors with Tadalista Super Active in stock. Here are some of the online drugstores with Tadalista Super Active available:

Tadalistastore.net has the Tadalista Super Active 20 mg in stock and sells it for $36 for 10 pieces, which is rather high, considering the web store has the “Tadalista” name on its website. Apparently, the “name” is just a marketing ploy to attract more buyers and not really an indication of cheaper pricing for the product.

Cheapgenericeddrug.com, on the one hand, has a more cut-rate pricing for Tadalista Super Active 20 mg. The same 10-pill amount here only costs $25.50, which saves buyers about $10 for the minimum purchase. These Internet stores cater to buyers all over the world, which includes consumers from the controversial USA, Canada, and Australia. Although not all of the countries of the world allow the importation of generic medications like Tadalista Super Active, online stores have found a backdoor in shipping their items which enable buyers from these areas to purchase although the importation of the product is technically illegal in some instances.

Conclusion and Rating

Good reviews and good pricing are available for Tadalista Super Active, so patients can indeed save more from this drug and at the same time get to experience relief from their impotence problem. As for the product rating, since there is no information on the US regulatory approval for the drug, there are still misgivings on the quality of this drug for erectile dysfunction management. But since there are good feedbacks, we can consider the drug effective and give it a 3 out of 5 rating. Nonetheless, patients should evaluate the risks they are facing when choosing to utilize generic medicines like Tadalista Super Active in place of the brand-name ones should they be prescribed with one.

References List

  1. Bpas.org: Erectile dysfunction (male impotence). Attainable at: https://www.bpas.org/more-services-information/erectile-dysfunction/
  2. Webmd.com: Symptoms & Risk Factors. Attainable at: http://www.webmd.com/erectile-dysfunction/guide/erectile-dysfunction-symptoms-types
  3. Healthline.com: Erectile Dysfunction in Young Men: Causes and Treatments. Attainable at: http://www.healthline.com/health/erectile-dysfunction/young-men#Prevalence2
  4. Indiamart.com: Fortune Health Care. Attainable at: https://www.indiamart.com/centurionpharmacy/profile.html
  5. Fildena.bz: About Us. Attainable at: http://fildena.bz/about-us.html
  6. Cui H, Liu B, Song Z, Fang J, Deng Y, Zhang S, Wang H, Wang Z. Efficacy and safety of long‐term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2015 Feb 1;47(1):20-4. Attainable at: https://www.ncbi.nlm.nih.gov/pubmed/24387078
  7. Pisansky TM, Pugh SL, Greenberg RE, Pervez N, Reed DR, Rosenthal SA, Mowat RB, Raben A, Buyyounouski MK, Kachnic LA, Bruner DW. Tadalafil for prevention of erectile dysfunction after radiotherapy for prostate cancer: the Radiation Therapy Oncology Group [0831] randomized clinical trial. Jama. 2014 Apr 2;311(13):1300-7. Attainable at: https://www.ncbi.nlm.nih.gov/pubmed/24691606
  8. Fda.gov: Questions and Answers for Cialis (tadalafil). Attainable at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm118692.htm

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