Sildenafil Ranbaxy 50mg/100mg Tablets Reviews: High Side Effects Profile

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Sildenafil Ranbaxy 50mg/100mg tablets are a sure way of getting rid of all the problems bothering a male related to his sexual health. The drug consists of sildenafil citrate which has been involved in treating all types of sexual dysfunctions including premature ejaculation. The drug is produced in the form of sildenafil loaded tablets and must be taken once every day to observe effects. Sildenafil Ranbaxy requires some time to activate itself, therefore, it must be taken sometime before indulging into a sexual activity. The drug is not indicated to be used in children as well as women. No other drug consisting of the same active ingredient must be used simultaneously with Sildenafil Ranbaxy. The drug can cause side effects like a headache and skin flushing if taken in excess amount, therefore, a doctor must be consulted before starting a therapy with it.

Ranbaxy Profile

Ranbaxy is an Indian pharmaceutical company which was built in the year 1961. In 1973, the company was made public while in the year 2014, it was acquired by Sun Pharma. Ranbaxy has its manufacturing plants in 8 different countries and a ground operation in 43. The products of this company are exported to 125 areas across the globe.

Ranbaxy Main Office

Ranbaxy Main Office

The company is involved in producing different generic versions of branded versions in addition to over the counter drugs. Many of its products have acquired a license from the US FDA while many are still under processing. [1]

Sildenafil in Scientific Publications

“Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells” by Caterina Mammi et al checked the property of sildenafil whether it reduces resistance towards insulin in humans. It is a fact that people who are suffering from diabetes have a reduced efficiency of phosphodiesterase type 5 inhibitors in them. Due to this reason, the PDE5 inhibitors cannot efficiently re-establish the function of the endothelium in these patients. According to the recent evidence, use of PDE5 in a therapy can result in an increment of the nitric oxide synthase expression and its proteins, especially in the heart as well as the cardiomyocytes. The study focused on analyzing the effect of sildenafil on the endothelial cells for the treatment of insulin resistance in vitro. For this purpose, the endothelial cells from the umbilical vein of the humans were chosen. These endothelial cells were treated with a certain amount of insulin both with and without the presence of 30 mM of glucose and 10mM of glucosamine. The process was also repeated in presence and absence of sildenafil citrate. It was seen that the expression of eNOS mRNA, as well as the PDE5, was increased due to the administration of insulin as assessed by Real-time PCR. Moreover, the Cytofluorimetric analysis was carried out according to which it was said that administration of sildenafil increased the production of nitric oxide in a significant amount in the basal cells. It was also said that a treatment with sildenafil citrate could normalize the side effects and harmful conditions produced due to the excess production of nitric oxide through the activation of eNOS by a reduction in the oxidative stress due to glucosamine and hyperglycemia. It was indicated from this data that sildenafil can be used in improving the activity of NOS in the endothelial cells exposed to a condition of insulin resistance. The study also suggested that sildenafil can be used for the improvement of the vascular functions in patients suffering from diabetes. [2]

“Viagra-associated serous macular detachment by” Polly Quiram et al revolved around the discussion of macular detachment as a side effect of treatment with Viagra containing sildenafil citrate. The purpose of this article was to find out about serous macular detachment linked with the use of Viagra. Two patients were selected for this study who were suffering from serious macular attachment, idiopathic in etiology and associated with the use of sildenafil citrate in the form of Viagra. Each of these patients was questioned about his history to determine the factors that contributed to his conditions and to rule out different causes of this detachment already known. Later, the patients underwent a detailed examination of their eyes which included inspection of macula using dilated biomicroscopic examination and the indirect examination of the retinal periphery using ophthalmoscope. Moreover, the color of the fundus was visualized with the help of photography involving OCT, ICG and FA analysis and the B-scan ultrasonography. An MRI was also performed for both the brain and the eyes. Brain, chest, orbits and the abdomen underwent a CT scan and the patients were also tested for their blood chemistries. Electrophoresis was performed and an analysis of cerebrospinal fluid was made using lumbar puncture. Chest radiography was also performed. It was seen that the patients suffering from serous macular detachments were due to the vitelliform deposits. They were also tested positive for the RPE mottling and peripapillary atrophy. None of the patients seemed to have any evidence of exudates, heme or any fibrosis. FA report showed that the patients did not have any focal areas where a leakage had occurred. ICG suggested in both early and late reports that choroidal vessels were engorged but with no leakage. OCT findings were suggestive of the macular detachments linked to the use of Viagra or its discontinuation. It was seen that the withdrawal from Viagra treatment had caused a complete treatment of macular detachment in one patient while a partial recovery in the other. [3]

How Sildenafil Works

Sildenafil citrate is a phosphodiesterase 5 inhibitor and works by controlling the cGMP-NO pathway. This pathway is normally required to relax the blood vessels and produce an erection in the penis. Phosphodiesterase type 5 enzyme hinders the normal working of this pathway and causes erectile problem. Sildenafil citrate, on the other hand, works vigorously to stop the activity of phosphodiesterase. In this way, the cGMP-NO pathway is restored and a normal erection is maintained. [4]

Sildenafil Ranbaxy Effects for Erectile Dysfunction

The effects of Sildenafil Ranbaxy are the production of an erection in males and a maintenance of this erection for a long time. The drug keeps a man happy and his partner satisfied and in this way, it enhances the quality and living standards of the patients using it. The drug can also be used sometimes to treat pulmonary arterial hypertension in both males and females. [5]

Doses and Scope of Therapy Recommendation

The recommended therapy of Sildenafil Ranbaxy differs in one patient from another and is mainly dependent upon the condition of a patient and the level of severity of his erectile dysfunction. Doctors advise the patients to consume one pill of Sildenafil Ranbaxy by mouth on a daily basis to observe effects and avoid adversities. Moreover, use of alcohol and heavy food should be avoided as both can cause a decrease in the efficacy of Sildenafil Ranbaxy. [6]

Toxicities and Warnings

Many users have reported side effects linked to the use of Sildenafil Ranbaxy. a headache is the most common adverse effect that occurs due to this drug in addition to stomach upset and diarrhea. The skin can become flushed and there might be a pain felt in the bones and back. In rare cases, Sildenafil Ranbaxy causes a decrease in the eyesight of the patient. It can also cause deafness in some patients and ringing of ears in others. Priapism i.e. unwanted erections is also a side effect of using this drug. [7]

Contraindications

Sildenafil Ranbaxy must not be used with other drugs consisting of sildenafil citrate as it can cause an exacerbation of side effects in the patient. Use of nitrates such as nitroglycerin and alpha blockers such as prazosin is also contraindicated during a therapy with Sildenafil Ranbaxy. Rifampicin, azole anti-fungal drugs, HIV protease inhibitors and antibiotics like azithromycin are also prohibited to be used with Sildenafil Ranbaxy as drug interactions might occur. [8]

Customer Reviews

Sildenafil Ranbaxy has received mixed reviews regarding its usefulness and side effects. A 41-year-old man suffering from erectile dysfunction stated in his review that the drug worked “flawlessly” for him. He mentioned how delighted he was when he finally got rid of the trouble in maintaining an erection. he also said that the drug did not cause any side effects in him.

Sildenafil Ranbaxy Testimonials

Sildenafil Ranbaxy Testimonials

A woman whose husband tried out Sildenafil Ranbaxy said that the drug did not work for her husband. She, however, mentioned that it also did not produce any side effects for him. Another customer of Sildenafil Ranbaxy who tried it for two weeks seemed quite satisfied with the way it worked without any complications. An unhappy customer was also spotted who said that he experienced ‘headaches’ and a fast heartbeat soon after taking Sildenafil Ranbaxy. He said that he would never recommend this drug to anyone.

Safe Dosage, Pricing, and Available Forms

Sildenafil Ranbaxy is available to be purchased from different drug stores present online. One of these drug stores is offering Sildenafil Ranbaxy in a pack consisting of 8 tablets each. Every tablet has 100 mg of sildenafil as an active ingredient. The pack is priced at 6.14 US Dollars which is a quite cheap price.

Sildenafil Ranbaxy Price

Sildenafil Ranbaxy Price

No information could be found about the shipping or delivery services provided by any drug store regarding Sildenafil Ranbaxy. This is problematic for some people who are living in far off areas of the world like United States, Canada, Australia, the United Kingdom and much more. Customers have the only chance of getting this drug by searching for it from store to store.

Sildenafil Citrate is the active component of sildenafil Ranbaxy. The medicine is sold in the form of tablets and the dose of these tablets has to be under observation to avoid experiencing unnecessary side effects. If a person is starting a therapy with sildenafil for the first time, 50 mg is considered suitable for it. After some time, the dose is adjusted to a well-suited amount 25-100 mg as per the response levels and tolerability of the patient.

Conclusion with Rating

Sildenafil Ranbaxy is one of those drugs which have a potential for producing good results. By reviewing the customer reviews about this drug, I can say that Sildenafil Ranbaxy does not promise any cure but can be of a great help. Some of the customers might fully heal by using it while others can get side effects only. In other words, it is nothing but luck. The price of Sildenafil Ranbaxy is quite nominal, however, the shipping is not available so it would be hard to get Sildenafil Ranbaxy. Customers can try the drug out if nothing else seems to be working but it should not be made a preference as Sildenafil Ranbaxy is associated with certain side effects. I am giving 3 out of 5 to Sildenafil Ranbaxy and would still insist the customers suffering from ED not to make it a first priority.

Reference List

  1. https://en.wikipedia.org/wiki/Ranbaxy_Laboratories
  2. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014542
  3. https://link.springer.com/article/10.1007/s00417-004-1099-0
  4. http://agence-prd.ansm.sante.fr/php/ecodex/notice/N0217221.htm
  5. http://www.onmeda.fr/medicament/sildenafil-ranbaxy-92686160.html
  6. http://www.doctissimo.fr/medicament-SILDENAFIL-RANBAXY.htm
  7. http://www.torrinomedica.it/farmaci/schedetecniche/Sildenafil_Ranbaxy_100_Mg.asp
  8. http://eurekasante.vidal.fr/medicaments/vidal-famille/medicament-gp5464-SILDENAFIL-RANBAXY.html
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