Sildenafil Mylan 100mg/50mg Tablet Review: Cheap Price Equals Quality Sacrifice

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Sildenafil Mylan 100 mg/50 mg is a cheap form of Viagra used to treat erectile dysfunction. Using Sildenafil Mylan ensures a better life and high satisfaction level in men who have lost confidence and are not able to carry out a sexual intercourse with ease. Sildenafil Mylan works to increase the rigidity of the erections and make them firm enough to reach the climax easily. The drug is instructed to be kept in a cool and dry place and must only be used by adult men. No major side effects are caused by Sildenafil Mylan but the drug is capable of interacting with certain drugs like nitrates.

About Mylan

Mylan is a global pharmaceutical business which has been registered in Netherlands. The company started working in 1961 in West Virginia and got relocated to a different location later. Mylan has a revenue of 9.1 billion Dollars annually.

Mylan Main Office

Mylan Main Office

Over 35000 employees are working under Mylan to produce generic medicines and specialty drugs consisting of different active pharmaceutical agents. The company is regarded as the second largest pharmaceutical business in the whole world. [1]

Research Work on Sildenafil

“Sildenafil citrate ingestion and prolonged priapism and tachycardia in a pediatric patient” by Brandon K. Wills et al discussed the side effect of sildenafil when administered in an underage patient. There is very little information about the side effects caused by taking sildenafil in a large amount in children. This study involved a cause in which a male child, 19 months of age suffered from tachycardia and prolonged priapism by unintentional administration of sildenafil in excess. This 19-month-old male accidently swallowed six tablets of Viagra, each consisting of 50 mg of sildenafil in it. The child was presented to the emergency department of a hospital 45 minutes after it. The weight of the child was 10.4 kg and he was presented with an increased heart rate, a decreased blood pressure and body temperature and very low rate of respiration. His face was mildly flushed and his penis was erect and normal in color. There was no increase in the dynamic force and there was no ectopy seen. It was also checked that his pulse was strong ad heart sounds were normal too. The child was given different intravenous fluids and was kept under observation in the pediatric department.

The patient showed signs of tachycardia and a tumescent penis with no pain up to 24 hours after ingesting Viagra in the first place. The child reported that he did not feel any pain due to this constant erection. After 7 hours of ingestion, the concentration of sildenafil was found to be 3900 nl/ml while that of N-desmethyl sildenafil was found to be 1700 nl/ml. it was concluded that in this case where a child ingested sildenafil in an amount of 30 mg per kg, the side effects observed were priapism and flushing of the face. Tachycardia was also found to occur in this patient which was asymptomatic and his priapism episode lasted for 24 hours until he was discharged from the hospital. He did not suffer from any painful erection hence, did not require any urologic intervention. This case was managed well by only giving supportive care. [2]

A study named “Sildenafil: Clinical Toxicology Profile” by Edward P. Krenzelok et al gave a detailed analysis of the toxicology profile of sildenafil in different patients. Sildenafil citrate is used for the treatment of erectile dysfunction. It has also been used in men to resolve problems related to hemodynamics and an impairment in the neural response required in the sexual stimulation. Sildenafil belongs to the category of phosphodiesterase type 5 inhibitors that stop the degradation of cyclic Guanosine Monophosphate and produces a relaxation in the smooth muscles of arteries in the penis. Corpus cavernosum is also relaxed and penile erection is achieved owing to sildenafil citrate.

Use of sildenafil citrate has also been associated with minor side effects which include a decrease in the diastolic and systolic blood pressure of the body, nausea, and stomach upset. The agent is also seemed to be involved in various drug interactions with medicines like nitrates and nitrates which can cause a development of hypotension in the body. This hypotension can cause a decrease in the coronary perfusion and can result in a myocardial infarction. The metabolism of sildenafil citrate occurs with the help of cytochrome P450 3A4. A drug which inhibits the normal working of this system of the liver can cause an increased concentration of sildenafil in the blood which can lead to the development of toxic effects in the body. One example of such drugs is the antiviral drugs that work by inhibiting the protease enzyme. According to the data derived from the American Association of Poison Control Centres Toxic Exposure Surveillance system, the unintentional use of sildenafil in a large dose in children is not associated with risks. However, adults can suffer from certain side effects which can be due to preexisting pathologies or use of other drugs simultaneously. [3]

How Sildenafil Acts

Sildenafil is a potent inhibitor of the enzyme PDE5 which helps in the breakdown of cGMP- a chemical messenger useful for vasodilation. As sildenafil blocks the activity of PDE5, the level of cGMP in the area increases which leads to marked vasodilation and increased blood flow in that area. Sildenafil accumulates in the penis so the blood flow in the rises to a specified level which is helpful in creating hard and longstanding erections. [4]

Sildenafil Mylan 100mg Effects for Erectile Dysfunction

Sildenafil Mylan100mg contains 100mg of sildenafil. The drugs accumulate in the penile organ to create a long-standing erection by increasing the blood flow in the helicine arteries of the penis. This effect helps in the management of erectile dysfunction. The drug contains sildenafil which is reported as one of the best solutions to erectile dysfunction. [5]

Recommended Doses and length of Therapy

A tablet per day is enough to maintain a good erection during sexual intercourse. It must be mentioned here that the drug is not a permanent solution to erectile dysfunction. Its effects last as long as its metabolites are in the blood. As the drug are eliminated, the effects are gone and the patient will have to take a new dose to maintain an erection. [6]

Side Reactions and Warnings

The side effects of sildenafil are very widespread and it is termed as class 3 drug in terms of safety. Yet it is used widely as its benefits weigh over its disadvantages. The undesirable effects start from flushing of the face, ringing in the ear and, if taken in very large doses, can end in heart attack like symptoms. Some other side effects involve dizziness, diarrhea, color blindness, memory problems and stomach problems leading to eating disorders. [7]

Drug-to-Drug Relation

The nitrate containing drugs cause some serious drug interactions which can lead to symptoms like decreased blood pressure and dizziness. This interaction if persisted longer, can lead to organ failure as the organ won’t be perfused with sufficient blood. Nitrates and sildenafil both act via the same mechanism to vasodilate, so sildenafil is strongly contraindicated with drugs for heart-related diseases.

Some other drugs which are prohibited with sildenafil are amlodipine, aspirin (at low doses), atorvastatin, Cialis, Lipitor, fish oil containing omega-3), and antibacterials like tetracyclines and cephalosporins. [8]

Customer Reviews

Sildenafil Mylan is yet to receive any feedback from customers on online websites. Drugs which are not having any reviews from the customers are not deemed reliable by the experts. There is no guarantee whether Sildenafil Mylan treats erectile dysfunction so it would be a mere risk to buy this drug without confirming. Moreover, the risks and side effects associated with Sildenafil Mylan are not known hence, it must not be used blindly. It can be a waste of time and money of the customers. Men who are suffering from erectile dysfunction should instead focus on other drugs consisting of sildenafil citrate to treat their problem with surety and safety.

Price, Forms, and Available Dosage

Sildenafil Mylan is available at several pharmaceutical businesses operating online. The drug can be availed in a packet consisting of 12 tablets. Each tablet consists of 100 mg of sildenafil citrate in it. The price of this packet is fixed at 29.39 US Dollars.

Sildenafil Mylan Price

Sildenafil Mylan Price

There is no information regarding the shipping of Sildenafil Mylan to any area of the world. No online pharmacy is involved in this business hence, there is nothing much to say about the availability of Sildenafil Mylan in countries like the United Kingdom, Canada, the United States and Australia.

Sildenafil Mylan is manufactured in the form of hard tablets. Sildenafil is the primary ingredient of these tablets which is to be used carefully to treat erectile dysfunction without causing an overdose. While most patients start off with 50 mg of sildenafil, the average dose of sildenafil can fall between 25 mg to 100 mg.

Conclusion with Rating

Sildenafil Mylan is a cheap generic version of Viagra but with a lack of validity. I do not trust Sildenafil Mylan as I could not find any customer reviews in reference to the efficiency of Sildenafil Mylan. Sildenafil Mylan is also not available for shipping to different parts of the world. Therefore, it is going to be difficult for me to locate this drug in order to purchase it. I would give Sildenafil Mylan 1 out of 5 and would urge people suffering from erectile dysfunction to consider other options instead of Sildenafil Mylan and save their time and money.

Reference List

  5. Mylan 25 mg, 50 mg %26 100 mg film-coated tablets/
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