Sildenafil Citrate 100mg/50mg Tab Reviews: You Can’t Take This Erectile Dysfunction Product with Alcohol

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Sildenafil Citrate 100 mg is the generic version of the famous Pfizer-made drug, Viagra; and it’s not your ordinary generic product for ED (erectile dysfunction)—it is actually made by Pfizer, the same manufacturer for the brand-name product for impotence famous worldwide. It is ironic, though, that Pfizer made its own generic version of the drug although it is restricting other companies to follow suit and produce the same generic product. It is expected that Pfizer’s generic Sildenafil will be lower in price than the branded product, although the actual projected cost is not entirely clear yet. It seems that Pfizer is rather unwilling to relinquish its control over the reins of the impotence market that it also made its own generic product to compete with the already persecuted generic Sildenafil market.

The product, Sildenafil Citrate has the same ingredients as its brand-name drug family member. It also does not have any difference at all with the generic Sildenafil products such as Kamagra from Ajanta, Zenegra, Vigora, Zeagra, Fildena from Fortune Healthcare, Nizagara, Malegra from Sunrise Remedies, and seemingly countless other generic Indian medicines for impotence.

This generic Sildenafil product from Pfizer also comes in various product formulations apart from the traditional oral hard pill forms. Pfizer also reproduces the Sildenafil goods in liquid forms, injectable forms, lozenges, jelly, and oral jelly forms aside from the customary tablet and pill formulations. The product, however, does not have a sublingual/under the tongue pill formulation. Although possible and unlike the India generic products, though, there are no Sildenafil Citrate products coalesced with other drugs, for instance, SSRIs (selective serotonin reuptake inhibitors) for premature ejaculation such as dapoxetine, duloxetine, fluoxetine, paroxetine and others (“Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase‐5 inhibitors in the treatment of premature ejaculation” by Polat et al in 2014) [1].

Generic Sildenafil Citrate 100 mg’s product monograph is comparable with Viagra’s monograph since they have the same ingredients but only vary in status. Both drugs from Pfizer have the same benefits and the same indications (the Sildenafil contents of both drugs are for male impotence, for pulmonary hypertension, BPH-LUTS, pregnancy preservation and more) [2], plus the same special considerations such as avoidance of administration for blood pressure medications, bodybuilding hormones, grapefruit juice, and others [3].

About Pfizer

Pfizer prides itself on being one of the “world’s premier pharmaceutical companies” [4]. It is true, though, considering the company has a lot of achievements and contributions to the medical and pharmaceutical society in the past decades. It is a unique company of 150 years of experience in the pharmaceutical business and is rapt at research for its biopharmaceutical products [5].

The company, Pfizer is known for a plethora of its products, such as Viagra, but Pfizer is known significantly for its production of vaccines which changed the healthcare landscape. Also, Pfizer is famed for its treatments/cures for even the dreadful and feared illnesses of all time [5].

Pfizer Main Office

Pfizer Main Office

Pfizer is a 10,000+ company with branches all over the world [5]. It is such a reputable company that whenever its brand is uttered in the medical field, the products are always associated with quality and efficacy—there are no trepidations surrounding any of the products of the company.

The acquisitions of Pfizer made it the large company it is today (the largest pharmaceutical company in the world, actually) [6]. Amongst the companies, it has acquired included prominent names such as Wyeth, Warner-Lambert, King Pharmaceuticals, Pharmacia, Hospira, and others [6].

Pfizer’s products and facilities are not only US FDA accredited but are also hailed by other drug agencies. Also, Pfizer’s products are not only effective, but they are also famous and well-needed by consumers around the globe, as most of the products of the company are those clients can’t sometimes live without (Advil, Robitussin, ChapStick, Dimetapp, etc.) [6].

Scientific Studies on Sildenafil

Sildenafil Citrate is being considered as an adjuvant therapy for patients with premature ejaculation when primary treatments have proven ineffective for the condition. The study of Chen et al in 2003, “Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation” assessed whether the concomitant allocation of Sildenafil and SSRI drugs is efficacious in managing PE/premature ejaculation symptoms [7]. Patients with PE were initially treated with topical lidocaine, but patients who were unresponsive were given Paroxetine 20 mg, and the ones who were not satisfied with the Paroxetine administration were given with Sildenafil as an addition to their treatment [7]. 38 patients out of the 138 responded favorably to lidocaine, while 42 out of the 100 administered with Paroxetine were significantly improved by the drug.56/58 of the remaining patients were given with Sildenafil and they all noticed an amelioration of their ejaculatory function using the drugs [7]. However, out of all the patients, there were 2 who did not respond to any of the treatment at all [7]. Based on this study’s results, Sildenafil combined with Paroxetine and counseling was able to remedy the PE suffered by the patients [7].

Hellstrom also discussed how PDE5 (phosphodiesterase type 5) inhibiting drugs can also be indicated for the management of premature ejaculation (“Current and Future Pharmacotherapies of Premature Ejaculation” in 2006) [8]. Hellstrom’s paper in 2006 mentioned that during the period, drugs used in treating premature ejaculation were only used off-label, as there were no FDA approved oral/topical managements for PE [8]. The co-administration of Sildenafil/Tadalafil/Vardenafil with SSRIs may prevent the side effects caused by SSRIs such as low libido and possibly erectile dysfunction [8]. Also, the mechanism of action of these PDE5 inhibitors also has an “indirect” effect which aids in increasing ejaculation latency time [8]. There are possible recommendations for efficacious for premature ejaculation in patients, although the Hellstrom recommends that further studies be conducted to establish the drugs which are recommendable for PE [8].

The paper by Nurnberg in 2002, “Depression, antidepressant therapies, and erectile dysfunction: clinical trials of sildenafil citrate (Viagra®) in treated and untreated patients with depression” expounded on how erectile dysfunction and depression were related and that Sildenafil Citrate is also beneficial in managing erectile dysfunction with depressive symptoms [9]. This study by the authors mentioned that the clinical trials conducted for ED caused by depression and SSRI treatment indicated that Sildenafil is effective in dealing with the depressive symptoms as well as the dysfunction [9]. Nurnberg and the other authors suggested that treating erectile dysfunction requires a holistic approach in order to achieve optimal results in treating the disorder and the related symptoms [9].

Description and Mechanism of Action of Sildenafil

Sildenafil Citrate is also known as a PDE5 inhibitor drug with a chemical formula of C22H30N6O4S and with a molecular weight of 474.5764 g/mol. The drug was initially used as an angina drug due to its effects on the PDE5 enzyme found in the myocardial tissues, although it was discovered that the drug exerts its effects in the endothelial tissues of the penis. Sildenafil is not naturally occurring in nature, and it is synthesized in a laboratory.

Although the drug is used in various applications (for instance, high blood pressure management, female sexual arousal disorder treatment, urinary retention, depression [9], and more), Sildenafil’s action in male impotence is the one it’s famous for. The process on how Sildenafil works is actually pretty simple, as Sildenafil only prevents the action of the enzyme PDE5 in order to sustain an erectile response in patients. When the PDE5 enzyme is suppressed in patients with impotence, the normal cycle of erectile function follows. Sildenafil only makes sure that the levels of the essential chemical signals are sufficient enough to instigate an erection in patients with impotence.

Sildenafil Citrate Effects for Pulmonary Hypertension and Erectile Dysfunction

There are actually a lot of benefits to the use of Sildenafil Citrate in patients and not only in the area of impotence treatment. It is apparent that Sildenafil Citrate is indispensable when it comes to erectile dysfunction treatment, as the drug offers its benefit of reinstating erectile function in patients, but it is also used in various clinical applications which are linked to the PDE5 function in the body.

Besides impotence, Sildenafil Citrate is also being allocated for daily use in patients with pulmonary arterial hypertension, prostatic enlargement urinary symptoms, and woman-related fertility treatments. Apart from those, Sildenafil is also being utilized for veterinary use (for dogs and cats particularly) for heart and lung problems, as the active ingredient is an invaluable mediator of the pulmonary vasculature, which makes it efficacious for treating related diseases for dogs, cats, and other animals [10].

However, though Sildenafil proves useful for a large number of medical considerations, patients should always screen their Sildenafil sources carefully and not be tempted to purchase the drug from dubious sources. For instance, there are a lot of online sellers distributing Sildenafil, some in unnamed tablets and some in bulk powder forms. Usually, these sources have not verified where they actually make these “Sildenafil” drugs, which means that these drugs may have negative clinical and nursing implications in the long run.

How Long does it Take to Work and Duration of Therapy

You can take Sildenafil Citrate in forms such as 50 mg, 100 mg, or 25 mg, depending on the doctor’s recommendation for your optimal use. Sildenafil Citrate is recommendable to be taken before intercourse, preferably about 1 hour prior to the intended sexual activity. On the question of how long does it take to work, Sildenafil Citrate drugs take about 30 minutes to an hour before the effects show up. As for the duration, Sildenafil Citrate lasts for about 4 hours before the drug wanes off.

There are inquiries about the intake of the drug with food. The manufacturer information on Sildenafil states that the drug is not advisable to be taken with food or any fatty substances, which means that the drug is not good to be taken with milk, as milk is fatty in content. Alcohol is also not advisable to be consumed with Sildenafil, although it is probably considered by most of the patients. Alcohol can hinder the efficacy of Sildenafil and it can also contribute to the exacerbation of the drug’s side effects.

Side Effects and Warnings

Patients are sometimes troubled by nagging side effects from Sildenafil Citrate. Some patients report of headache, facial redness or flushing, dizziness, and other reactions from the use of the drug. Sildenafil Citrate’s side effects are not totally observed in patients, although a significant fraction of the patient users of the product is affected by the adverse events. In order to avoid these side effects, patients should be careful to follow all the doctors’ instructions for the drug and also be sensitive enough to notice subtle changes induced by the drug which can indicate symptoms for more grave problems.

Drug Interactions

Did you know that Ketoconazole cannot be taken with Sildenafil? This is due to the fact that anti-fungal medications tend to inhibit the efficacy of Sildenafil Citrate in patients. Besides the drugs included in that category, Nitrates, anti-retroviral products, and others are also contraindicated with the use of Sildenafil Citrate, as these drugs interfere with the bioavailability of Sildenafil and may also exacerbate the side effects.

Customer Reviews

Due to the popularity of the drug, Sildenafil Citrate, and its manufacturer, there are a lot of product reviews available for the Pfizer’s generic Sildenafil Citrate drug on the internet:

Pfizer’s Sildenafil Citrate Feedback

Pfizer’s Sildenafil Citrate Feedback

RoystheBoy posted his comment for Pfizer’s product and gave it an 8 out of 10 as he mentioned that the erection he’s got from the drug are “not exceptional” like the ones he’s previously tried. He is considering larger dose options for a sufficient erectile response from the drug.

Pfizer’s Sildenafil Citrate Customer Experience

Pfizer’s Sildenafil Citrate Customer Experience

Tpmdawg is also one who related his use of Sildenafil. According to him, he has no concerns with getting erections, but he is experiencing trouble in maintaining the response. He rated the drug 10 out of 10 because Sildenafil was able to sustain his erections and he was generally pleased with the outcome.

Pfizer’s Sildenafil Citrate Consumer Reports

Pfizer’s Sildenafil Citrate Consumer Reports

According to Mark Adams, he was able to use the drug successfully for erectile dysfunction, although the patient recommended that men should not be too dependent on the drug like he did.

Maxime Evrard, another client for Sildenafil Citrate, praised Sildenafil for being a reliable drug for his erectile dysfunction concerns. To-date, he has not had any concern whatsoever for the product, which is good to hear from a patient using the product.

On the other hand, Christopher Campbell said that the drug does not take effect immediately. According to his personal recollection, Sildenafil took at least an hour to fully take effect (full hardness for the erection). However, it is already stated in the drug information for Sildenafil that the drug usually takes an hour or so to elicit the full effects.

Price, Available Forms, and Dosage

100 mg, 50 mg, and 25 mg forms are available for Pfizer’s generic Sildenafil Citrate but in various forms and not in the tablet form alone. You can purchase generic Viagra online, but you have to ask the vendors specifically about the Pfizer-made brand, as you may be sent other brands for the medication.

Pfizer’s Sildenafil Citrate Prices

Pfizer’s Sildenafil Citrate Prices

Being a generic product, Sildenafil Citrate’s cost is more affordable than the actual Viagra from the same maker. You can avail of the drug for $3.50 each, although the cost of Sildenafil Citrate, like its contemporaries, tends to get cheaper as you get more of the product. Although the initial cost of Sildenafil is $3.50 each, the price can get to a dollar each.

Some online shops are able to offer free shipping for their products, some charge minimal amounts, but some also charge exorbitant prices. You should watch out for the shipping costs for any of the product you purchase online, as the high fees may negate your savings for the product you’re planning to buy.

Concerning shipping, technically, there are regions of the world with prohibitions for the shipments of generic products. It is mainly due to patent protection laws for the brand-name products. However, it is still enigmatic how buyers from almost all parts of the world are able to avail of and import generic Sildenafil products, especially in the United States. The United States is currently exclusive to Pfizer’s Viagra, but there are reviewers from the US stating that they were able to avail of impotence products online and without their products being seized by the Customs. In any case, patients should always check the legitimacy of the product shipping to their countries, so that snags in product distribution should be avoided.

Conclusion and Rating

There is no need for a lengthy discussion for Sildenafil Citrate 100 mg. A drug made by Pfizer, it is exceedingly recommendable and approvingly effective for impotence. The drug is cheap, it is efficacious, and it is made by probably the best pharmaceutical company in the world known for changing the medical landscape. Sildenafil Citrate is 5 out of 5 and should it be available and prescribed for your condition, you shouldn’t hesitate to pursue the product for your condition.

Reference List

  1. http://onlinelibrary.wiley.com/doi/10.1111/and.12289/abstract
  2. https://www.drugs.com/sildenafil.html
  3. https://www.drugs.com/drug-interactions/sildenafil,viagra.html
  4. http://www.pfizer.com/about
  5. https://www.linkedin.com/company-beta/1185/?pathWildcard=1185
  6. https://en.wikipedia.org/wiki/Pfizer
  7. Chen J, Mabjeesh NJ, Matzkin H, Greenstein A. Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation. Urology. 2003 Jan 31; 61(1):197-200. Accessed at: http://www.goldjournal.net/article/S0090-4295(02)02075-7/abstract
  8. http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2006.00309.x/full
  9. http://www.sciencedirect.com/science/article/pii/S0090429502016916
  10. http://www.diamondbackdrugs.com/sildenafil-for-veterinary-use/
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