Pro-Agra 150/100mg Tablets Sildenafil Review: Bio-Baxy Super Active Impotence Product Unpopular with Clients

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Pro-Agra 150/100mg appears to be one of the choices for impotence medication available in the market. Pro-Agra contains the PDE5 (phosphodiesterase type-5) inhibitor Sildenafil Citrate, which is effectual in ameliorating the erectile function in patients affected with impotence. Patients affected with erectile dysfunction find it constantly grueling to generate the appropriate erectile response even if the males are aroused [1]. Since this condition is chronic, there is the need for the patients to have medical intervention for their condition. PDE5 inhibitors such as Sildenafil Citrate contained in Pro-Agra has been proven efficient in helping males elicit the proper erectile function when needed [2].

The product Pro-Agra is manufactured by the company BioBaxy, which is another company in India. The brand has several product formulations available: tablets/hard pills and jelly or oral jelly forms. Pro-Agra is also available in 150 mg and 100 mg forms. Unlike the other generic Viagra brands, there is no “super active” variant for Pro-Agra, or Sildenafil Citrate with SSRIs (selective serotonin reuptake inhibitors) such as dapoxetine, fluoxetine, or similar drugs, which are also helpful in managing premature ejaculation in patients with coexisting erectile dysfunction (ED) and premature ejaculation (PE) [3].

About BioBaxy from India

BioBaxy Technologies, as a company, has its strength focused on export [4]. Besides supplying its products in India, it is also distributing its buyers from locations such as Europe, South Africa, African countries (Mauritius, Zimbabwe, Botswana, Mozambique, Namibia, Congo, Nigeria, Ghana, etc.) and Asian countries such as the Philippines, Sri Lanka, and others [4].

BioBaxy Technologies Location

BioBaxy Technologies Location

BioBaxy Technologies is capable of manufacturing products in the area of herbal medicine/Ayurvedic preparations and pharmaceutical-grade drugs for the therapeutic expanses of weight loss, diabetes, cholesterol, blood pressure, joint pain, stress, skin care, immune boosters, hair care, and others [5].

What is significant to BioBaxy is it is known for its ability to “dropship” its products for the benefit of “reseller” pharmacies. This means that the company ships its products to clients of pharmacies across the globe using courier services such as DHL, FedEx, USPS, and other shipping companies [5].

Concerning quality, BioBaxy is certified by the World Health Organization, the FSSAI (Food Safety and Standard Authority of India) and ISO (9001:2008).

Clinical Publications on Sildenafil

There are other drugs used to manage impotence in males. Studies like the one from Andrade et al in 2000, “In vitro effects of sildenafil and phentolamine, drugs used for erectile dysfunction, on human sperm motility” intended to determine the effects of the impotence drugs Sildenafil Citrate and phentolamine on human sperm motility [6]. Sperm/semen samples were integrated with either phentolamine or Sildenafil and were scrutinized for the outcome of the drugs on sperm motility [6]. The administration of the 200-microg/mL of Sildenafil ensued to no effect on the sperm samples’ motility, but the highest (2000-microg/mL) dose altered sperm motility by relegating the sperm activity to 50% [6]. Phentolamine, on the other hand, had no effect when administered in 20-microg/mL. Phentolamine’s 200-microg/mL dose alone lessened sperm motility, while its 2000-microg/mL demonstrably halted any sperm movement [6]. The authors concluded that the highest administered dose of Sildenafil had a substantial effect on sperm movement, and it is primarily due to the pH decline brought about by the drug’s concentration [6].

Other authors, Alp et al, in their 2012 paper, “Effects of sildenafil citrate, isoniazid, and streptomycin on testicular tissue and epididymal semen quality in rats”, assessed the protective effect of Sildenafil Citrate on testicular tissue caused by plausible toxicity instigated by streptomycin and isoniazid in rats [7]. 80 rats were included in the study and were grouped into 8 and administered with various drug combinations [7]. These rats were then evaluated after 45 days of treatment [7]. According to the results, the authors assimilated that Sildenafil Citrate was able to increase sperm motility and concentration, testosterone levels, and FSH/LH levels [7]. Alp et al determined that overall, Sildenafil had a beneficial effect on sperm and hormonal parameters and had a protective effect in the damages induced by the direct administration of streptomycin and also in the toxicity caused by isoniazid [7].

Novel formulations for the consumption of Sildenafil Citrate were devised, such as the fine granular formulation from one Korean pharmaceutical company. The study by Zheng et al in 2014, “Pharmacokinetics and bioequivalence of sildenafil granules and sildenafil tablets in Korean healthy volunteers” was performed in order to test the bioavailability of the fine granule Sildenafil against the bioavailability of the conventional Sildenafil tablet [8]. 40 volunteers were included in the study and were made to take the regular and the newly formulated Sildenafil granules [8]. The result of the analysis conveyed that the pharmacokinetics of both the regular sildenafil tablets and the novel formulation of the product were bioequivalent, which ushered the authors to the conclusion that the novel granule Sildenafil form is a viable method of administration in the near future [8].

Sildenafil Mode of Action

Any drug containing the active pharmaceutical ingredient Sildenafil Citrate is able to help patients deal with impotence symptoms by ameliorating the erectile reaction through the PDE5-Nitric Oxide-cGMP (cyclic guanosine monophosphate) pathway. Sildenafil Citrate is one of the PDE5 inhibitors, meaning, the drug actually suppresses the action of the PDE5 enzyme.

There is a need to suppress PDE5 action in patients with impotence, as the individuals suffering from ED are also suffering from an imbalance in the system which mediates the erectile response. In patients with ED, the PDE5 degrades the cGMP even before any erectile activity takes place. Sildenafil merely inhibits PDE5 for a few hours so that the levels of cGMP necessary to potentiate vasodilation and smooth muscle cell relaxation are maintained. This action of inhibiting PDE5 causes the patients to re-establish the correct levels of the cGMP which leads to the potentiation of the erectile reaction in the presence of sexual stimulation.

Pro-Agra Effects for Erectile Dysfunction

As one can expect from medicines with Sildenafil Citrate, Pro-Agra can be expected to be helpful in reinstating the lost erectile response in patients with erectile dysfunction. The active pharmaceutical ingredient in the drug can aid the patients in regaining the response by ensuring the balance in the neurotransmitters mediating the erectile function.

Due to the efficacy of the drug’s active pharmaceutical ingredient, the patients can expect abetted erectile response during intercourse and the individuals can expect the effect to last for about 4 hours. However, although Pro-Agra’s Sildenafil content is able to improve the erectile function, it is not equivalent to curing the impotence symptoms altogether. Though Sildenafil improves erectile reaction, it can’t be expected to cure the condition, as it only gives temporary relief.

Recommended Extent of Therapy and Doses

Pro-Agra, like any Sildenafil tablet, is instructed to be taken on an as-needed basis, and only once in 24 hours. Patients may be given and initial dosage of 50 mg to 100 mg, depending on the dosage that the physicians deem fit for the patients’ ED severity. More severe cases of erectile dysfunction may be administered with larger doses, even exceeding 100 mg, but the milder forms of ED may be administered with 50 mg or 25 mg, depending on the dose the patients are able to respond to.

Side Effects and Alerts

Common complaints from the Sildenafil administration include headaches, facial flushing, redness/hotness of the skin, vision problems, dyspepsia, and heartburn. However, all of these side effects initiated by Sildenafil use are only ephemeral and should not persist in the patients. As the drug is excreted from the system, so should the side effects fade away. However, patients experiencing extended duration of the side effects should consider phoning their doctors or should seek medical attention, as the protracted extent of the side effects in the patients may mean something more serious than simply a long side effect.

Drug Interactions

In general, patients should inform their doctors about all the current medications they are taking, especially when their erectile dysfunction occurs with other medical conditions. Patients with high blood pressure and heart considerations are not allowed to take their nitrate medication with Sildenafil due to the probability of increased side effects such as the critical lowering of their blood pressure. Apart from the nitrates, there are other drugs which are not advisable to be consumed with Sildenafil, such as fungal medications and medicines for HIV or Hepatitis. Doctors can safely determine the drugs which are benign to use with Sildenafil, so males should be transparent with their medicines and should disclose even their seemingly neutral herbal remedies and other supplements.

Customer Reviews

Albeit it is in our best interest to present client evaluations for Pro-Agra, there were simply none to show for the drug’s integrity. There were no buyer comments for the product Pro-Agra, although it was sold on the internet.

The company making Pro-Agra (BioBaxy), is fairly new, so we can assume that the patients are a bit reticent when it comes to trying out the new medication. Also, the going gets tough for novel players in Indian generics for impotence, due to the presence of “connoisseurs” in the business (experienced pharmaceutical companies), which have the more popular brands of erectile dysfunction product. The presence of known Indian brands for ED puts Pro-Agra in a difficult position, and more so robbing it of the chance to be tried out by patients for their ED.

Buyers tend to go for drugs with experience (reviews) and long tenure in the business, and it seems that Pro-Agra does not have both yet, which may predispose patients to elude from the drug and prefer other brands.

Forms, Pro-Agra Price, and Dosage

Pro-Agra is manufactured by BioBaxy in 100 mg and 150 mg tablet forms and also in other product forms such as jelly or oral jelly forms. Although rather new to the pharmaceutical industry, there are already suppliers having the drug in stock online:

Pro-Agra Prices

Pro-Agra Prices

Pro-Agra is actually one of the cheapest products for erectile dysfunction available online. Buyers can have the drug for $0.73-$0.94 when others sell their products for $2 or more each pill. Should Pro-Agra have been proven effective, it could be a great choice price-wise for an erectile dysfunction product.

Pro-Agra Shipping Cost for USA

Pro-Agra Shipping Cost for USA

International shipping is enabled for Pro-Agra and buyers from across the globe can purchase the product. This includes buyers from the USA, Australia, and Canada, and all the other regions of the world. There is no difference in terms of shipping cost for the buyers from any point of the world, although the store owners charge more when buyers prefer more expensive courier options for their orders.

Conclusion and Rating

Pro-Agra is a “newbie” drug in the impotence drug industry. Its company-maker was only established in 2009, while its counterparts such as Cipla, Sun Pharma, Ajanta, Zydus, and others were incepted 50+ years ago. The drug contains the same Sildenafil Citrate contained in the impotence products of these reputable Indian companies; however, Pro-Agra did not have any consumer report for its efficacy yet. This puts qualms on the drug’s possible ineffectiveness; but, since there was no existing complaints or news for the discontinuation of the product, we can presume that Pro-Agra may also be effectual for impotence treatment. Nevertheless, due to its dearth of reviews, we only give it 2 out of 5. However, the drug is still, in part, recommendable, as it is very affordable and even more economical than most ED drug brands.

Reference List

1. Nhs.uk: Erectile dysfunction (impotence). Obtainable from: http://www.nhs.uk/conditions/Erectile-dysfunction/Pages/Introduction.aspx

2. Goodrx.com: PDE5 Inhibitors. Obtainable from: https://www.goodrx.com/pde5-inhibitors

3. En.wikipedia.org: Selective serotonin reuptake inhibitor. Obtainable from: https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor

4. Pro-agra.com: Profile. Obtainable from: http://www.pro-agra.com/

5. Biobaxy.com: Welcome to Biobaxy Technologies India. Obtainable from: http://www.biobaxy.com/

6. Andrade JR, Traboulsi A, Hussain A, Dubin NH. In vitro effects of sildenafil and phentolamine, drugs used for erectile dysfunction, on human sperm motility. American journal of obstetrics and gynecology. 2000 May 31; 182(5):1093-5. Obtainable from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~ecnZZf:3

7. Alp H, Cirit U, Tas M, Rifaioglu MM, Hatipoglu NK, Aytekin I, Yucel M, Firat U, Ozmen MF, Seker U, Eren LB. Effects of sildenafil citrate, isoniazid, and streptomycin on testicular tissue and epididymal semen quality in rats. Urology. 2012 Oct 31; 80(4):953-e9. Obtainable from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~ecnZZf:8

8. Zheng R, Kim BH. Pharmacokinetics and bioequivalence of sildenafil granules and sildenafil tablets in Korean healthy volunteers. International journal of clinical pharmacology and therapeutics. 2014 Jun; 52(6):530-6. Obtainable from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~G1F3HZ:6:@[email protected]@/cgi-bin/sis/search2/d?./temp/~b1nXNL:[email protected]

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