Perfopil 50mg/100mg Sildenafil Reviews: Poor Viagra Generic by Aurochem Laboratories

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Perfopil 50mg/100mg is meant to treat erectile dysfunction due to the presence of sildenafil citrate in the composition. Perfopil can be availed in the form of film-coated tablets in two different strengths for fighting erectile dysfunction of different severities. It is advised to keep the drug away from direct sunlight, heat, and humidity to protect it. Perfopil has only been approved to be used by men over 18 years in order to gain maximum satisfaction in their sexual life and to experience normal erections. The users commonly complain of experiencing dyspepsia, stomach upset, a headache and flushing of skin while using this drug. The use of certain medications like nitrates, alpha blockers, alcohol and other recreational drugs is strictly not encouraged as it can lead to various complications within the body.

About Aurochem Laboratories (i) Pvt. Ltd

Aurochem Laboratories is regarded as a fast growing company which is located in Mumbai, Maharashtra. This company has been existing in India for over 3 decades and is involved in manufacturing and supplying high-quality drugs belonging to different areas of medicine.

Aurochem Laboratories Location

Aurochem Laboratories Location

The drugs manufactured by Aurochem Laboratories cover the therapeutic segments of antifungals, NSAIDs, oncology, impotence drugs, anti-malarial drugs, cardiovascular health and much more. The company takes pride in producing over 450 drugs in different forms like tablets, creams, ointments, powders, dry syrups and capsules. Aurochem Laboratories aspire to eliminate diseases to improve the quality of life one day. [1]

Scientific Studies on Sildenafil

“Sildenafil Improves Sleep-Related Erections in Hypogonadal Men: Evidence From a Randomized, Placebo-Controlled, Crossover Study of a Synergic Role for Both Testosterone and Sildenafil on Penile Erections” by Vincenzo Rochira et al studied the use of sildenafil in treating the erectile problems encountered by men during their sleep. The study was meant to check how sildenafil affected the erections in a state of sleep and how it was related to androgenization. For this purpose, the results shown by administration of sildenafil in a few test subjects who were suffering from hypogonadism were evaluated. This evaluation was made both before and after the testosterone replacement therapy. The therapy was also carried out in a group consisting of control subjects. 24 men were selected who were having hypogonadism while another 24 healthy men were selected to serve as control group. The level of testosterone in those suffering from hypogonadism was found to be extremely low. The monitoring of rigidity and the nocturnal penile tumescence were carried out in these patients at nights and after evaluating the results were assigned either sildenafil in 50 mg dose or placebo. This medicine was to be taken an hour before going to bed on the second and the third day of penile monitoring. The tests were carried out two times in people who were suffering from hypogonadism i.e. once before being subjected to testosterone replacement therapy and one after experiencing it. Those belonging to the control group were, however, tested for once only. The patients were analyzed under different parameters which included the number of erections, duration of these erections, maximum levels of rigidity and the total increase in the circumference of the penis. Results were drawn and it was seen that the administration of sildenafil in the patients improved the NPTRM criteria as compared to placebo. In hypogonadal individuals, it caused a restoration of the penile erection. The use of sildenafil and testosterone therapy in combination resulted in improvement of NPTRM parameters positively. It was also seen that the combination therapy was more effective than either of the drugs used alone. It was concluded that sildenafil is capable of improving problems related to erections during sleeping. Also, there is a positive synergistic effect of testosterone and sildenafil in treating this cause. [2]

“Phosphodiesterase 5 inhibitors and nitrergic transmission—from zaprinast to sildenafil” by Alan Gibson et al focused on the relationship between phosphodiesterase type 5 inhibitors like sildenafil with the nitrergic transmission. It is known that the normal action of phosphodiesterase type 5 is to terminate the different actions within the cell particularly those of the second messenger system involving cyclic Guanosine Monophosphate (cGMP). Hence, it can be said that administration of the agents which cause an inhibition of this enzyme can not only increase the action of the endogenous agents which are dependent on the signaling from cGMP but also prolong it. This includes the release of nitric oxide as a neurotransmitter from different nerves which are nitrergic in nature. By far, sildenafil and zaprinast are the most commonly used phosphodiesterase type 5 inhibitors and they have been proving to be vital in the explanation of cGMP and the role it plays during the nitrergic transmission. Sildenafil, in particular, has proven to be extremely useful in the treatment of erectile dysfunction. The role of sildenafil in treating sexual dysfunction in females is also under consideration; however, no evidence seems to support this fact by far. The excellent use of sildenafil in clinical practice has encouraged the scientists to search for more PDE5 inhibitors that can be used to enhance the nitrergic functions to treat other diseases. [3]

Mechanism of Sildenafil Action

Sildenafil works by stopping phosphodiesterase type 5 which is responsible for the flaccidity of erections. It also prolongs the relaxation of muscles present in the corpus cavernosum. Moreover, the administration of sildenafil produces dilation in the vessels leading towards the penis which ensures the maximum amount of blood flow. Sildenafil enhances the physiological effect of nitric oxide and by accumulating the cGMP in the penile muscles; it produces an erection which is maintained easily for a long time. [4]

Perfopil Effects for Erectile Dysfunction

Perfopil is used to provide a treatment to males who are facing problems in getting an erection and keeping it for a long time. This condition is commonly known as erectile dysfunction in which a male fails to attain an erection hard enough to proceed a sexual activity. Use of Perfopil not only ensures an erect penis but also provides a feeling of orgasm numerous times. In addition to erectile dysfunction, Perfopil can be used as a remedy for pulmonary arterial hypertension because it is capable of decreasing the blood pressure by dilating the blood vessels. Other benefits of using Perfopil include an enhanced sexual performance and increased quality of life. By treating pulmonary arterial hypertension, the drug can also increase the quality of life. [5]

Suitable Doses and Extent of Therapy

Perfopil must always be taken after getting a consultation from the doctor. The drug is meant to be taken orally with or without consuming food. The drug must not be chewed or crushed inside the mouth to avoid irritation or an unpleasant taste. Perfopil requires 15-20 minutes to activate itself and start working; therefore, it must be consumed at least 30 minutes before starting a sexual activity. In an ideal situation, it must be taken once in 72 hours. Use of alcohol must not be continued in excess as it has a high probability of reacting with the drug. [6]

Side Effects and Alerts

Consumption of Perfopil is associated with a few side effects which can be easily tackled. The most usual of them is experiencing a headache. A user can also feel indigestion and unusual flushing of the face and other parts of the body. Muscle pain and back aches can also be seen in addition to a runny nose. These side effects tend to vanish within a few hours and up to 24 hours in case of muscle pain. The user should immediately contact a doctor if the side effects start worsening instead of going away. [7]

Drug Interactions

Drugs like ritonavir and saquinavir can modify the pharmacokinetic properties of sildenafil present in Perfopil if used together. Because Perfopil decreases the blood pressure, it can interact with nitrates to produce hypotension. Perfopil can also interact with drugs like cimetidine, alcohol and certain anti-hypertensive drugs to inhibit the cytochrome P450 system and liver enzymes. Other drugs like ketoconazole and erythromycin can increase the blood concentration of Perfopil. [8]

Customer Reviews

Perfopil can be regarded as an infamous drug in the pharmaceutical market because the drug is yet to receive any type of response from the customer’s’ side. This either implies that Perfopil has not been advertised properly or that it is not reckoned as an effective drug by people. Irrespective of what the reason is, experts advise the customers not to try out new drugs which lack customer reviews and information regarding its effect. Consuming such drugs can be hazardous to the human health and can generate a lot of complications which become difficult to treat. Perfopil must not be used and other medicines which consist of sildenafil and are known to be safe and effective should be tried out instead.

Perfopil Forms, Price, and Dosage

Customers can buy Perfopil from certain vendors which are working online. One of such vendors, dropshipmd.com is selling 100 mg of Perfopil at different prices depending upon the size of the order. The unit price for buying 100 or lesser number of pills of Perfopil is 1 USD. The unit price decreases as the total number of pills in order increases.

Perfopil Pricing

Perfopil Pricing

There was no vendor found online who was involved in the retail of Perfopil. The only companies involved in the shipping of this drug are wholesalers. This means that the people belonging to different regions of the world like Canada, Australia and America might find it hard to obtain this drug.

Perfopil is manufactured in the form of conventional pills including sildenafil as the primary ingredient. Two different pills of varying potency i.e. 50mg/100 mg can be found. The dose of Perfopil must be carefully adjusted in a way that an overdose can be avoided. 50 mg is the normal dose for starting a therapy while it can be changed to 100 mg in severe ED and to 25 mg in the mild cases.

Conclusion with Rating

I don’t consider Perfopil as a good remedy for erectile dysfunction mainly because it lacks in so many different aspects. The presence of Perfopil on the internet is not appreciated as not even a single review has been given by the customers who have used it. I also could not find any information regarding the purchase of Perfopil. The only websites which are offering Perfopil for purchase online only take wholesale orders. Perfopil does not enjoy delivery services and the only way to buy Perfopil is to search for it from shop to shop. Perfopil has nothing favorable to offer to me so I would have to reconsider about it. I am giving Perfopil a rating of 1 out of 5 and would ask everyone to find better alternatives to this drug which are worth spending money on.

Reference List

  1. http://www.aurochemlaboratories.com/at-a-glance.html
  2. http://onlinelibrary.wiley.com/doi/10.2164/jandrol.05077/full
  3. http://www.sciencedirect.com/science/article/pii/S0014299900008244
  4. http://www.sonuspharma.com/viagra-mechanism.html
  5. http://drugs.webmd.boots.com/drugs/drug-421-ak-taine ophthalmic.aspx?drugid=421&drugname=ak-taine ophthalmic
  6. http://perfopil-100-mg.blogspot.com/
  7. https://www.cialis.com/
  8. http://www.personalhealthzone.com/drug_interactions/sildenafil_viagra.html
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