Penegra Xpress 100mg/50mg Tablets Zydus Reviews: Infamous ED Drug for Exceptionally High Price

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Penegra Xpress 100mg/50mg is manufactured in the form of chewable tablets which consist of sildenafil citrate. The drug is indicated to be used in sexual disorders of men and can be easily used by people who face difficulty in swallowing hard tablets. Penegra Xpress claims to treat flaccidity of the penis and allow the user to experience multiple orgasms. It is also termed as a drug which can improve the quality of life of a patient who is suffering from a sexual dissatisfaction due to erectile dysfunction. The drug is associated with minor side effects like reddening of the skin and a headache. It is meant to be used by males over the age of 18 and must not be consumed by females and kids.

About Zydus (Alidac)

Zydus Cadila is a famous pharmaceutical company which was established in 1952. The company claims to provide a well-planned scheme for health care including different formulations with various active pharmaceuticals for both humans and animals.

Zydus Cadila main Office

Zydus Cadila main Office

Zydus Cadila is termed as the fourth largest company in India which deals with different pharmaceuticals. The company owns a number of manufacturing units and 8 of them are fully approved by the USDA. The medicines manufactured by this company cover the areas of cardiovascular health, dermatology, respiratory drugs and drugs for the treatment of infections. [1]

Sildenafil in Scientific Publications

A research study named “Sildenafil: A 4-year update in the treatment of 20 million erectile dysfunction patients” by Culley C. Carson III et al monitored the effectiveness of sildenafil treatment in patients who were suffering from erectile dysfunction. Sildenafil citrate can be regarded as an agent that has received international approval for being used as a treatment for erectile dysfunction. This agent is used orally has played a major role in revolutionizing the treatment regimens and schemes for tackling sexual disorders in males in a more effective way. Sildenafil citrate is classified as an agent which belongs to the category of phosphodiesterase type 5 inhibitors. These PDE5 inhibitors work vigorously in selective areas of the body, particularly the corpus cavernosum and its smooth muscles and tissues to help the patients fight this disease. The agent is more useful and is preferred to other remedies because it has an ability to treat a variety of erectile dysfunctions caused due to different reasons. Moreover, ED of all severities ranging from low to severe response to sildenafil but on different levels. It has been estimated that over twenty million men have gained benefit from the treatment involving sildenafil citrate which has provided them with great results. Even such types of erectile dysfunction the etiology of which is quite difficult to treat such as ED due to severe diabetes, ED due to prostatectomy and ED due to an injury to the spinal cord, all have been found to respond to sildenafil treatment. Like every other agent which is a PDE5 inhibitor, sildenafil is not advised to be used by people who are already taking nitrates because of their heart problem. However, those who are suffering from a cardiovascular disease and are not taking nitrates for it can take sildenafil without any risk factors. Also, the risks of side effects of the cardiovascular system in patients who are consuming sildenafil are no different than those who are not using it. Different investigations that were made in order to find out the pharmacological effect of sildenafil upon the myocardial tissue of coronary artery supports the claim that it is a safe medication. Sildenafil has also found to be safe in patients who were taking other drugs like medicines for treating diabetes, hypertension and cardiac problems. [2]

“Influence of sildenafil on central dopamine-mediated behavior in male rats” by F. Ferrari et al checked the effect of sildenafil on the behavior of the male rats which was controlled by dopamine receptors. In this study, two different experiments were carried out to check the effects of sildenafil on the behavior of male rats. Data was collected from both the experiments and was matched and compared. The information collected from the first experiment performed showed that when the rats were given sildenafil orally in the dose of 1 mg/kg, the rats experienced an enhanced occurrence of erections. There was also an improvement and enhancement seen in the homosexual mounting and the anogenital self-grooming. What is interesting was the occurrence of this improvement in the group of rats which were sexually experienced with no significant occurrence in those that were not experienced sexually. In the second experiment, the rats were given a pre-treatment with sildenafil in either 0.5,1 or 10mg per kg. It was observed that there was a modification in their behavioral signs which were thought to be regulated by D2 and D3 agonists. These rats showed a low typical behavior and sedation when given 10 mg per kg of sildenafil. [3]

Sildenafil Mode of Action

Sildenafil is a member of the category consisting of Phosphodiesterase type 5 inhibitors. Phosphodiesterase type 5 is an enzyme which is available in abundance in the corpus cavernosum of the penis. The normal action of this enzyme is to stop the accumulation of CGMP by breaking it down. This leads to a deficiency of cGMP in the penile musculature which can intensify at times and cause erectile dysfunction in males. Administration of a PDE5 inhibitor like sildenafil can lead to stoppage of this enzyme from breaking cGMP. cGMP gets collected in a large amount and collaborate with nitric oxide to cause erections. [4]

Penegra Xpress Benefits for Erectile Dysfunction

Penegra Xpress is used by men who are experiencing dissatisfaction in their sexual life. The drug is specifically indicated to be used in the treatment of sexual dysfunction. Penegra Xpress not only improves the firmness of the penile erections but also work to improve their duration of action. It has sildenafil citrate in its composition which provides the user an opportunity to experience multiple numbers of orgasms and to reach the climax within a short period of time. Premature ejaculation can be prevented and a normal sexual life can be acquired once again. [5]

Doses and Length of Therapy Recommendations

It is recommended for the users to place Penegra Xpress on their tongue and let it dissolve. The chewable form of the drug can be chewed and swallowed without using water. The best way to get maximum output from a single dose of Penegra Xpress is to use it 15 to 20 minutes before indulging into any kind of sexual activity. The drug must be taken just before having a meal or immediately after having it. A heavy meal rich in lipids can cause a hindrance in the normal working of Penegra Xpress. It must also be kept in mind not to use an excessive amount of alcohol while consuming Penegra Xpress because it can also interfere with the absorption and working of it. [6]

Adverse Reactions and Alerts

Using Penegra Xpress can cause certain side effects in some patients which can range from mild to harsh in terms of severity. The most common side effect of using this drug is developing a headache as reported by the majority of the customers. It can also cause erythema or reddening of the skin in the patients, especially their facial skin. A patient using Penegra Xpress can suffer from shortness of breath and flushing. The drug is sometimes associated with the development of hay fever in certain people while in others, it can cause dyspepsia and diarrhea. Nose bleeding is also a commonly reported side effect of Penegra Xpress. Rarely, the medicine can also cause changes in vision. [7]

Drug-to-Drug Relations

The use of nitrates along with Penegra Xpress is strictly not recommended as both drugs can lower the blood pressure of the person to dangerous levels. The same effect can be observed when a person uses alpha blockers like prazosin in combination with Penegra Xpress. Drugs for HIV infections like ritonavir and certain drugs used for the treatment of tuberculosis e.g. rifampicin are contraindicated to a person using Penegra Xpress. Other drugs which are not advised to be used during the entire course of therapy include clarithromycin, St. John’s wort and azole antifungals. [8]

Customer Reviews

Penegra Xpress 100 mg has not been able to receive much appreciation from the customers because it does not have any customer reviews on its name. The importance of customer reviews cannot be denied as they provide a solid foundation for convincing a customer into buying a particular brand. A medicine which lags behind in this category is generally not considered as worth giving a try and people are discouraged to try it out. Such medicines can also be associated with a number of side effects as there is no guarantee of them being safe. Hence, it is advised that customers should not think of trying Penegra Xpress on their own as it can be a threat to their health. They should instead focus on buying a similar drug which is more reputed and safe.

Price, Market Forms and Penegra Xpress Dosage

Penegra Xpress can be purchased from a number of vendors working online. It is available at in a pack of four. Each tablet has 50 mg of sildenafil citrate in it. The price per pill on this website is fixed at 1.25 US Dollars.

Different vendors operating online are also offering a shipping service to the international customers residing in other areas like Canada, the United States, Australia and the UK to get Penegra Xpress delivered to their doorstep. For this purpose, the customer can use slow shipping which is economical and costs 29.97 USD or a fast service by paying 59.95 USD.

Penegra Xpress Price

Penegra Xpress Shipping Options

Penegra Xpress Shipping Options

Penegra Xpress is available in the form of tablets which can be chewed. The drug comes in two different potencies i.e. 50 mg and 100 mg according to the amount of sildenafil present in them. It is a common practice to start a therapy with 50 mg of sildenafil. The dose can later be adjusted to any amount between 25 and 100 mg according to the response made by the patient towards sildenafil.

Conclusion and Rating

Penegra Xpress is an average drug with standard quality. I cannot term it as a cheap drug because there is a number of cheaper generic medicines for ED available on the market. While I can enjoy the shipping service offered for Penegra Xpress, there are no customer reviews to support the authenticity of Penegra Xpress. Since there is no response from other customers about Penegra Xpress, I would personally suggest everyone who is looking forward to trying it to give second thoughts to their decision. I would give 2 out of 5 to Penegra Xpress because it still lacks in many aspects.

Reference List

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