Penegra 100mg/50mg Capsule Zydus Reviews: Alcohol and Pregnancy Incompatible Viagra Version

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Penegra is a drug which is specialized for the treatment of erectile dysfunction in males. Penegra includes the active pharmaceutical ingredient Sildenafil Citrate, which also happens to be the main active ingredient in the famous drug, Viagra. Penegra, however, is classified as a “generic Viagra” drug, along with the likes of Kamagra, Caverta, Suhagra, Manforce, and others. All of them are termed generic Viagra products due to their Sildenafil Citrate content. These all differ from generic Cialis; as though Cialis is classified as a PDE5 (Phosphodiesterase Type-5) inhibitor, Cialis contains Tadalafil and not Sildenafil Citrate.

Impotence or erectile dysfunction/ED is caused by a number of factors, but it is mainly correlated with aging, as geriatric males tend to have narrower capillaries supplying the penile tissues with blood. However, not all elderly males are with ED; the causes of erectile dysfunction go beyond age—there are factors such as disease (diabetes, chronic high blood pressure, cardiovascular disease, prostate cancer, etc.), lifestyle factors such as smoking and drug abuse, medication side effects, psychological disorders, and others [1].

Erectile dysfunction is also different from the condition premature ejaculation; erectile dysfunction is the chronic difficulty of males in eliciting the erectile response, while premature ejaculation is a condition where males fail to delay ejaculation and ejaculate too soon with very little penetration or sexual stimulation [2]. Medical interventions for erectile dysfunction include the oral administration of the PDE5 inhibitors which benefits the patients by abetting the erectile response of the males. However, these PDE5 inhibitors are not only indicated for impotence; they are also used for their benefits for pulmonary hypertension, prostatic enlargement, and is also used as an off-label treatment for woman/or for female-related concerns (pregnancy, IUI, etc.). On the other hand, premature ejaculation is treated with SSRIs or selective serotonin reuptake inhibitors, although these drugs are considered to have a harmful effect on sperm motility and integrity with chronic use [3].

Penegra’s main difference from Viagra is its price since the cost of Penegra is utterly lower than the branded Viagra product. Penegra is manufactured by the company Zydus Cadila in India, and the brand is reproduced in several product forms such as pills, tablets, capsules, jelly, and even in spray form.

Zydus Cadila Information

“Dedicated to life” is the company, Zydus Cadila’s catchphrase. According to the company, it is one which was inducted in the year 1952, which makes the company 60 years in the healthcare business [4]. This gives Zydus Cadila ample expertise in the field of manufacturing pharmaceutical formulations in the areas of active pharmaceutical ingredients (APIs) for human clinical conditions, and also medicinal products for animal healthcare.

The enterprise is situated in the textbook pharmaceutical company setting in India (Gujarat). Zydus is considered the 4th largest pharmaceutical company in India [5] due to its billions’ worth of revenue (INR). Zydus Cadila is significant for its achievement of marketing the first drug for diabetic dyslipidemia, which the company named “Lipaglyn”.

Zydus Cadila Main Office

Zydus Cadila Main Office

Apart from manufacturing generic counterparts for the brand-name with the same active composition, Zydus Cadila is also renowned for its capacity to reproduce drug biosimilars, which are the 100% identical drug counterparts of the brand-name medications. The company’s eminent biosimilar is “Excemptia”, which is the world’s first biosimilar product for Adalimumab, which is indicated for inflammatory arthritis therapy.

Currently, Zydus Cadila employs over 19,500+ people and is presently the domestic partner of large-scale companies such as Abbott, Hospira, Bayer, Takeda, IDRI, Pieris AG, Prolong Pharmaceuticals, and other big names in the pharmaceutical industry [6]. Zydus is a multi-awarded company which is accredited by the US FDA and other renowned drug regulating agencies [6].

Clinical Research on Sildenafil

Although it is proven that Sildenafil Citrate is efficacious in the management of erectile dysfunction in patients, there are studies which determined the preference of patients for Sildenafil or its fellow PDE5 inhibitor, Tadalafil. The study of Bai et al in 2016, “A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction” assessed the patient predilection for either Sildenafil or Tadalafil [7]. In this particular study, Chinese patients who were naïve to PDE5 inhibitor therapy were randomized to sequential Sildenafil 100mg-Tadalafil 20mg or Tadalafil 20mg-Sildenafil 100mg and were evaluated for their treatment preference for their extension treatment [7]. Based on the outcome for the evaluation parameters, results for Tadalafil were slightly better than the parameters for time concerns, sexual confidence, and the spontaneity aspect for intercourse [7]. Due to this, the patients preferred the use of Tadalafil over Sildenafil, although the results were positive for both drugs in terms of improving erectile function [7].

Apart from the apparent benefits of Sildenafil Citrate for impotence management, the drug’s action has been studied in the past for its various applications in the medical field. The paper of Arafa and Atteia in 2013, “Sildenafil citrate attenuates the deleterious effects of elevated ammonia” studied if Sildenafil exerts a protective effect in the hyperammonemic brain and applied this theory on rat models [8]. Rats were administered with ammonium chloride for 8 weeks and then given with Sildenafil Citrate for about 8 weeks [8]. The study’s data revealed that the Sildenafil treatment led to notable reductions in the lipid profile, plasma liver enzymes, and the brain casoase-3 mRNA and lipid peroxidation [8]. Sildenafil was able to protect the brain from oxidative stress in the case of hyperammonemia, which can have future applications in the medical industry [8].

Due to the blood flow-inducing effect of Sildenafil Citrate in patients and also brain blood flow in rat models, researchers such as Fayed and Gad also tried out testing whether the administration of Sildenafil Citrate also has its effects on trace elements Zinc/Zn, Iron/Fe, Copper/Cu, Cobalt/Co, Chromium/Cr, and Selenium/Se in the rat brain (“Effect of sildenafil citrate (Viagra®) on trace element concentration in serum and brain of rats” in 2011) [9]. The rodents were subdivided into two groups (one control group and the other was treated with Viagra) [9]. After dissecting the rats and administering tests for the serum concentrations of the trace elements, the researchers determined that Sildenafil administration increased the levels of Se and Cu, plus the Cr concentrations in the brain of the rats [9].

Description and Mechanism of Action of Sildenafil

Sildenafil Citrate functions as a PDE5 inhibitor. Based on the drug class name, Sildenafil Citrate is capable of inhibiting the effect of the enzyme PDE5 so that the erectile response can take place. The PDE5 enzyme is the one preventing the accumulation of the cGMP (cyclic guanosine monophosphate) nucleotide, which is essential in inducing vasodilation and smooth muscle cell relaxation in the penis. Since Sildenafil Citrate is able to suppress the action of PDE5 from breaking up cGMP concentration in the penile tissue. The cGMP levels are maintained to sufficient levels necessary to conjure up an erection in patients suffering from erectile dysfunction.

Penegra Benefits for Erectile Dysfunction

Using Penegra gives benefits to patients by enabling them to have restored erectile function even for several hours’ duration. Studies determining the efficacy of Sildenafil showed positive before and after effects for improved erectile function, even for patients with impotence of various origins.

Patients can anticipate better erectile function and improved performance due to their use of Penegra because of its Sildenafil Citrate content. Products with Sildenafil Citrate are proven efficacious in the management of erectile dysfunction in males. Results of studies for Sildenafil in the past years have been productive

However, for ladies, the use of Sildenafil Citrate has also been considered due to the advantages the drug can bring. Sildenafil is considered for the treatment of infertility and the maintenance of pregnancy. Apart from that, various uses for Sildenafil has already been identified as a result of productive studies for the drug [8,9].

Recommended Doses and Duration of Therapy

The dose recommendation for the intake of Sildenafil for naïve patients is 50 mg to 100 mg, but the usual prescription is the lowest dosage for safety purposes. Patients can move forward to higher doses of Sildenafil Citrate when the initial 50 mg did not work sufficiently for the individuals. Regardless of the prescribed dose for Sildenafil, patients should take only one dose of the product within a 24-hour period.

Penegra in regular tablet/pill form can be taken with water, although the jelly form of the product can be taken with or without any liquid as the oral jelly Sildenafil product is able to dissolute in the buccal cavity. If patients think that they drink alcohol with Penegra, they are mistaken—alcoholic drinks are prohibited to be consumed with Sildenafil, as the alcohol content of the products may obstruct the efficacious action of Sildenafil in patients. It would be a waste of product if patients should take alcohol with the drug, only to hinder its valuable effect in impotence.

Side Effects and Warnings

Side effects usually occur when patients are administered with Penegra and similar products, and the side effects can be attributed to the Sildenafil contents of the medications. The adverse events commonly reported by patients and also determined by clinical studies in the context of Sildenafil use include headaches, flushing, vision changes such as the bluish tinge-sight or blurry vision, and rhinitis or stuffy nose. These treatment-emergent adverse reactions are discernible in other patients taking the drug, but not all of the men taking the drug experience side effects. In actuality, only a small fraction of the patients are facing these side effects brought about by Penegra or any Sildenafil use.

Drug Interactions

Pharmaceutical products may interact with the Sildenafil content of Penegra, so this should be a cause of caution for most of the patients taking the drug. On top of the list for the drug interactions are pharmaceutical goods known to lower the blood pressure of the patients. Nitrates, for one, are largely responsible for the decreased blood pressure in patients, which means that individuals planning to take Penegra or any generic Viagra drug should avoid drugs containing the nitrate active content because the conjunctive administration of any nitrate drug and sildenafil may result to a catastrophic hypotension in patients.

Besides the general warning for nitrates and Sildenafil, the drug is also prohibited to be taken with other items such as fungal medication, antibiotics, antiviral medications, herbal preparations, and some vitamin supplements. If patients are already taking Penegra, then there is no reason for them to consume another PDE5-inhibiting medication or any herbal remedy with the same intent to improve erectile function. Not only shall the effect be redundant, but the side effects may also be exacerbated due to the co-administration of two impotence medications.

Customer Reviews

Penegra has several user reviews from one online pharmacy with the product in stock. Good evaluations from buyers of the product were all we can find for the product on a particular online pharmacy:

Penegra Feedback

Penegra Feedback

The buyer “Beast” gave Penegra 4 out of 5 for its efficacy. Beast went on to relate that among all the generic products he’s tried, Penegra was his favorite. He also commended how the store was able to send him his order promptly. However, there was no information as to why the rating was 4 and not 5 out of 5.

“Kevin”, another client, mentioned that he bought the 100 mg variant for Penegra but he cut the product in half. Surprisingly, he was able to get a good effect out of the half-a-drug. Kevin conferred Penegra with a perfect 5 score.

“Petite” also granted Penegra with 5 out of 5 for the quality of the product. According to him, his “recent batch works great” and also mentioned his intent of reordering from the same website for his Penegra stash.

Price, Available Forms and Dosage

Penegra hard pills come in 25 mg, 50 mg, and 100 mg formulations. The brand, “Penegra” also exists in several product formulations such as the jelly form and even in an unconventional spray form. Here are the prices for the tablet formulations for Penegra:

Penegra 25 mg Price

Penegra 25 mg Price

Penegra 50 mg Price

Penegra 50 mg Price

Penegra 100 mg Price

Penegra 100 mg Price

The minimum order quantity for Penegra in one online pharmacy (Clearskypharmacy.biz) is 12 pieces. Consumers can avail of Penegra for $1.83-$2.50 each, depending on the product strength and the order quantity. The difference for the prices is not too great, though, so it is also OK to purchase Penegra in the smallest possible order amount to test the product’s efficacy before getting loads of the item in one go.

Penegra Shipping Cost

Penegra Shipping Cost

There are online drugstores offering to ship for as low as $9.95 for the regular courier, but for a fleeter transit, buyers can opt for more expensive shipping options. Some stores offer free shipping for a certain amount of orders, which may be beneficial for those with larger orders.

Most of the online pharmacies ship to various locations around the globe, so buyers can expect their orders shipped to locations such as the USA, Australia, and Canada. There is no price discrepancy for shipments in various locations, so clients can anticipate the same postage rates for diverse settings throughout the globe.

Conclusion and Rating

Penegra 100mg/50mg is one of the good options to try for impotence due to its efficacious active pharmaceutical ingredient, Sildenafil Citrate. Based on the reviews from previous clients, Penegra has been effectual in patients with impotence, as the drug was able to abet the symptoms of erectile dysfunction in patients. Compared to other erectile dysfunction meds, the price of Penegra is just average, but all in all, the price for Penegra is yet more economical than the Viagra brand. Since Penegra has to have its US FDA approval yet, we can only bestow it with 4 out of 5. We find that Penegra is highly recommendable, and it should be one of your options for generic erectile dysfunction medications, should you be prescribed with one.

Reference List

  1. http://www.medicalnewstoday.com/articles/5702.php
  2. http://www.controlpe.sg/the-facts/difference-between-premature-ejaculation-and-erectile-dysfunction/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463894/
  4. http://zyduscadila.com/
  5. https://en.wikipedia.org/wiki/Cadila_Healthcare
  6. http://zyduscadila.com/
  7. https://www.ncbi.nlm.nih.gov/pubmed/27101805
  8. https://www.ncbi.nlm.nih.gov/pubmed/23343352
  9. https://www.ncbi.nlm.nih.gov/pubmed/22036616
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