Nizagara 100mg/50mg is one PDE5/phosphodiesterase type 5 inhibitor drug, which contains the active ingredient, Sildenafil Citrate. Since Nizagara contains Sildenafil Citrate, it is similar to Pfizer’s brand for erectile dysfunction, Viagra. The company manufacturing Nizagara is Combitic Global, a Japanese-Indian company which is concerned with the manufacture of pharmaceutical merchandise.
The products PDE5 inhibitors are renowned for their function for the treatment of male impotence , although these drug types are also being utilized for a myriad of medical applications. Drugs classified under the PDE5 category are Sildenafil (which is known as Viagra), Tadalafil (Cialis), and Vardenafil (or known also as Levitra). These drugs are highly efficacious when it comes to the treatment of erectile dysfunction, although they are, most of the time, worth more than the cost which regular patients can afford. The lesser priced products are also available, though, and are named “generics”. Nizagara belongs to the medications found in that category, along with famous less-pricey products known in the online market such as Kamagra, Fildena, and others. For Tadalafil, generic goods are also prevalent in the online market; for instance, buyers can avail of the same Tadalafil-containing drug for more than half less the price in items such as Tadalis, Sanafi, plus more brands.
Nizagara by Combitic Global has been mass-produced in several drug forms such as pills and film-coated tablets and in the forms of 100 mg and 50 mg. These drugs have the same intake regimen with the brand-name product (Viagra), which is taken on an as-needed regime . Although effective, Sildenafil products have various warnings indicated for its use, as the active ingredient causes several interactions with the patients, especially those with other clinical conditions. Safety is paramount, so patients should take Nizagara and Sildenafil drugs only under the direct supervision of the medical practitioners.
About Combitic Global (Uni-Sule Pvt. Ltd)
The Japanese-Indian enterprise, Combitic Global Caplet Pvt Ltd, operates in the fields of biotechnology and pharmaceutical production, and the company is also a specialty pharma . Little data is published on the internet for this company, which makes it hard to profile. Most of the links which supposedly direct to the business information to Combitic are redirecting to online pharmacies and not to Combitic Global records.
Referring to the on-site informational segment by the company Combitic Global, it has an old name of Unisule Pvt. Ltd. This enterprise was inaugurated in the year 1982 and is identified as a drug manufacturer and trader in India . Combitic Global Caplet is adept at reproducing tablets (beta lactum and non-beta lactum), hard gel capsules (non-beta lactum, beta lactum), and some common drug formulations . Combitic has 175 employees which help in the facilitation of its operations .
Currently, the only accreditation known to the public for Combitic Global is its ISO 9001:2008 certification  and by default, its India FDA approval, as the enterprise could not perform its campaigns without being allowed by the Indian FDA to operate.
Scientific Studies on Sildenafil
In order to institute the use of Sildenafil products for erectile dysfunction, there were studies oversaw and piloted to assess the efficacy of the PDE5 inhibitor for erectile failure. McMahon, Samali, and Johnson in 2000, “Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction”, evaluated if Sildenafil is effectual for managing impotence symptoms in patients . 304 male erectile dysfunction patients were able to accomplish the clinical trial, 278 were administered with the drug Sildenafil . These patients were able to respond to an average of 100 mg dose of the PDE5 inhibitor . 188 were able to have their impotence symptoms bettered by the drug . However, the data collected by the researchers signified that half of the patients (or more) had side effects due to their utility of the medication, albeit the adverse events were only fleeting and trifling . It was also discerned that prior users of injectable treatments went back to using the injectable impotence treatments, which ascertained that patients still find the injectable treatments efficacious for ED management . Side effects determined for Sildenafil use in this study were headaches, nasal congestion, dyspepsia, and dizziness .
There are a lot of products verboten with Sildenafil Citrate, and amongst them was grapefruit juice. The paper composed by Jetter and his colleagues, “Effects of grapefruit juice on the pharmacokinetics of sildenafil”, studied the impact of grapefruit juice intake in patients also administered with Sildenafil . In Jetter’s study, patients were given 50 mg of Sildenafil and grapefruit juice an hour prior to the administration of the drug . According to the results collated from the study, the intake of grapefruit juice increases the bioavailability of Sildenafil, although it is also delaying the absorption rate for the drug . As the data in the study suggests, using grapefruit juice makes the action of Sildenafil unpredictable, which makes it un-recommendable with Sildenafil . Albeit this concomitant use of Sildenafil and grapefruit juice is not 100% determined to be deleterious, patients are still advised against the use of both products simultaneously .
Surprisingly, Sildenafil Citrate as a PDE5 inhibitor has a lot of uses determined for it. In the past, there are various researches piloted to seek more functions for the product. The drug has then been deliberated for its use in females as an agent for pregnancy preservation. Shanmugam et al in 2014, in their research, “Sildenafil vaginal suppositories: preparation, characterization, in vitro and in vivo evaluation”, investigated the drug kinetics and other aspects of vaginal suppositories containing Sildenafil Citrate . The researchers determined that for the functions intended for the use of Sildenafil in female patients, the vaginal suppository delivery system is efficient in eliciting the desired effect . Compared to the oral Sildenafil route, the Sildenafil suppositories provide ample targeting for the uterus in patients administered with the drug .
Sildenafil in Action
The erectile function relies on the engorgement with blood of the penile tissues preceding sexual stimulation. This function is mediated by neurotransmitters nitric oxide, cGMP (cyclic guanosine monophosphate), and the PDE5 enzyme. In the ideal system, there is a sufficient amount of cGMP released during sexual stimulation, which provides the adequate stimulus for the vasodilation of the arteries surrounding the penis, which then instigates erection. PDE5, the enzyme manufactured by the penile tissues, is usually released post-intercourse, in order to bring back the penis’ initial size.
However, in patients with ED, PDE5 is released much earlier, which encumbers the supposed erectile response. The job of Sildenafil is to impede the premature action of PDE5 in order for the erection to take place. In a nutshell, Sildenafil is able to instigate the erection mechanism in patients, although the process is a bit more complex than simply the drug directing greater blood flow to the penile tissues.
Nizagara Effects for Erectile Dysfunction
Patients with ED waited long for the appearance of generic, less-costly remedies for impotence. At long last, generic products surfaced in the pharmaceutical market and the upsurge of the generic drugs for impotence led to a lot of buyers trying out the less expensive drugs in place of Viagra. Although technically, these drugs are still somewhat illegal, buyers patronized the drugs due to their desperation for cheaper treatments for their debilitating erectile condition.
Nizagara, being one of the Sildenafil products for erectile failure, is also efficacious for impotence due to its potent ingredient. Clients can expect an ameliorated erectile response due to their use of the impotence remedy, as the Sildenafil content is capable of bringing about an enhanced reaction to sexual stimuli for the patients.
Recommended Doses and Duration of Therapy
At the outset, impotence patients may be administered with 50 mg of Sildenafil  just to test how well patients are going to react with the medication. However, patients seem to be more adapted to the 100 mg dose  despite the efficacy of the 50 mg concentration. Patients diagnosed with more severe forms of erectile dysfunction, however, are recommended to have greater doses of the drug, or are also advised to take concomitant treatments for erectile dysfunction, in order to ensure further treatment success. In the question of the drug taking how long to work, Sildenafil/Nizagara takes an average of 1 hour before taking effect.
According to the previous study for Sildenafil , the drug is acting harmoniously [for the patients] with grapefruit juice. Also, Nizagara cannot be administered when patients took alcoholic drinks prior, as aside from the possible critical hypotension, patients may also experience impeded efficacy from Sildenafil due to alcohol.
Side Effects and Safety Warnings
Most studies determined treatment-caused side effects with the use of Sildenafil for impotence, although patients deem the side effects trivial. Complaints of side effects include redness, stomach aches, heartburn, flushing, blurry sight, and dizziness . These complaints should be able to go away expeditiously, as these minor events do not take long before they are gone.
However, there are side effects which trouble the patients more; for instance, loss of eyesight and/or hearing, altered heart rate, nose bleeding, burning feeling, anxiety, eye bleeding, behavioral modifications, and more troubling events . In the case of these occurrences, patients should be able to air their concerns in the hospital setting, in order to avoid permanent damages from the drug.
There is actually a surfeit of drugs found to offset Sildenafil/Nizagara’s effect (about 2053) , although these drugs can be summed up in several major drug categories. Nitrates, for one, are those which patients should avoid, due to their similar hypotension-inducing capability as Sildenafil Citrate. Surprisingly, antifungal medications, too, are also known to interact with Sildenafil, so patients should generally avoid drugs with ketoconazole or any analogous content. In addition, antiviral medications should also be veered away from, as well as other impotence treatments. Safety is important, so patients should be well-aware of the drugs they can and cannot take with Sildenafil Citrate.
For the benefit of other clients, reviews are published by clients who are able to try out medications. In the case of Nizagara, fortunately, there were clients who were brave enough to publicize their experience for the erectile dysfunction medication. Some of the users were able to post their comments for Nizagara in one online forum website:
The first comment for the product by a person named “Curt” indicated his disappointment for Nizagara. Based on his statement, he did not feel any effect from the drug, which he bought from a Canadian pharmacy.
Nonetheless, the proceeding comments begged to disagree with Curt’s experience. Comments from “Ted” and “Rudy” were upbeat for Nizagara, though. Ted stated that the drug functioned “great”, while Rudy said that the Nizagara pills worked “very well”. We can infer from the comments that these clients were gratified as a result of the drug intake.
Price, Available Forms, and Dosage
As mentioned prior, Combitic Global created Nizagara in two forms, in 100 mg and the lower 50 mg. Since the product came from India, most of the residents of the country can have unrestricted access to the drug, provided that they can show their prescriptions to their local drugstores.
For international buyers, though, Nizagara can be purchased online, as some of the Internet stores have the product too. The cheapest cost buyers can pay for Nizagara is $1.37 each tablet, and the most expensive the drug can get is $3.88. The price depends on the product strength of choice of the patients and also depends on how much they are willing to procure from the online drugstore.
Specific prohibitions for Nizagara’s distribution are not available, so we can assume that almost everyone from any country can get ahold of Nizagara via online shopping. There are usually two options for the buyers, which include the regular and the swifter options. Clients residing from the USA, Australia, and Canada are going to pay as much shipping fee as the buyers from other parts of the world, as the postage is charged contingent to the courier selection of the buyers ordering Nizagara.
Conclusion and Rating
Nizagara 100mg/50mg may as well be your future choice for erectile dysfunction management. There are some reviews for the drug and some complaints too, which you can refer to when deciding on purchasing the drug. The hitch to this drug, however, is the limited information available for its supplier/maker, which we only know as an ISO-certified company. Extensive data regarding the drug and its producer should be evaluated, but since there was not much, we can’t be too sure about the drug’s efficacy. Nizagara, however, may be still given 3 in 5, due to its middling price and due to the presence of several reviews accessible for it. We only recommend its use when your doctors give you the acknowledgment of using the product, and that’s for your safety and your peace of mind.
- https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~CLKGV2:46:@[email protected]@/cgi-bin/sis/search2/d?./temp/~LLSoby:[email protected]
- https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~CLKGV2:49:@[email protected]@/cgi-bin/sis/search2/d?./temp/~LLSoby:[email protected]
- https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~CLKGV2:43:@[email protected]@/cgi-bin/sis/search2/d?./temp/~LLSoby:[email protected]