Nitro 50mg Spray Sildenafil Review: Infamous Viagra Equivalent by AstraZeneca

[show-testimonials taxonomy='{current_page_id}' orderby='menu_order' order='ASC' layout='grid' options='theme:card,info-position:info-above,text-alignment:left,columns:1,rating:on,charlimitextra: (...),image-size:ttshowcase_small,image-shape:circle,image-effect:none,image-link:on']
Image result for medical spray bottle

Nitro 50 mg Spray is like a liquid Viagra which is meant to treat sexual dysfunction in a matter of minutes. The drug is nothing but liquefied form of Viagra which has been incorporated with food-grade propylene glycol as a medium. Nitro 50 mg Spray is innovative because it tends to word much faster than the tablet or the capsule form of Viagra. The effect of this drug is said to last for one to one and a half hour. The drug must be sprayed under the tongue which makes its absorption much faster and easier by bypassing the digestive system. Nitro Spray consists of sildenafil citrate just like any other erectile dysfunction treating drug. The same side effects are claimed to be observed by using this spray. It must be used only by men and women should avoid it.

About AstraZeneca

AstraZeneca is a multinational company dealing in different pharmaceutical products and having a shared origin of Sweden and the Britain. The company shifted its headquarters to England in the city of Cambridge in the year 2013. The Research and Development centers of AstraZeneca are located at three different locations. On the basis of sales revenue, it is regarded as the eighth biggest pharmaceutical company of the world.

AstraZeneca Main Office

AstraZeneca Main Office

The company was established 17 years ago on 6th April, 1999. Over 50 thousand people are affiliated with this drug manufacturing business and the total revenue of it is 24.708 billion US Dollars. Dugs related to the categories of vascular system, gastrointestinal system, psychiatry, neurology, respiratory system, oncology, infectious diseases and the inflammatory diseases are produced by AstraZeneca. [1]

Sildenafil in Clinical Research

A research by Shahzad G. Raja et al named as “Sildenafil: Emerging Cardiovascular Indications” discussed certain conditions related to the cardiovascular system that could serve as indications for sildenafil therapy. Sildenafil citrate was first discovered in the year 1989 duirng a series of experimentation in which chemical agents were being tested to target phosphodiesterase type 5 to treat different conditions like coronary heart disease. The studies that were carried out during 1990s did not prove to be beneficial in establishing a positive role of sildenafil for the treatment of heart diseases. Nevertheless, the agent was eventually found to be useful in the treatment of erectile dysfunction and other issues related to the sexual health of the males hence, its effect against impotence was established. Several controversies arose when some incidents were reported in which patients using sildenafil suffered from adverse effects related to the condition of their hearts. The indications of sildenafil citrate are increasing especially after a discovery that the enzyme phosphodiesterase type 5 is not only present in the corpus cavernosum of the penis but also in other tissues of the body such as pulmonary vessels and coronary arteries, platelets, skeletal muscles, muscles of certain viscera, venous vasculature and the tracheobronchial muscles. The study focused on how sildenafil could be used in different types of diseases like pulmonary arterial hypertension, etc due to a widespread presence of PDE5 in different parts of the body. [2]

“The Effect Of Sildenafil On Apomorphine-Evoked Increases In Intracavernous Pressure In The Awake Rat” by Karl –Erik Andersson et al checked the effects of sildenafil administration on the intracavernous pressure of the rats. The basic purpose of this study was to check how sildenafil citrate affected the erectile activity in an awake test animal. Male Sprague Dawley rats were considered as the test animals for this study. These rats were kept awake and were administered with apomorphine subcutaneously in a dose of 100-250 micrograms per kilogram. After accomplishing this step, the intracavernous pressure was measured in these rats. After an interval of ten minutes, these rats were further administered with sildenafil in a dose of 100 microgram per kilogram intravenously after the rats had been given a second dose of apomorphine. These rats were checked for different parameters before and after the administration of sildenafil. These parameters included peak intracavernous pressure, duration of response and time of first response. It was seen that the administration of apomorphine produced a rhythmic boost in the intracavernous pressure. Two components could be seen in this pressure increase. It was also seen that the increase in the intracavernous pressure induced by apomorphine was prolonged by the administration of sildenafil. The burst like changes in the pressure were abolished by the bilateral transaction of the pudendal nerves. The overall response of intracavernous pressure due to apomorphine as measured by the area under the curve was found to be augmented to a significant extent due to the administration of sildenafil. It was also seen that the administration of N-nitro-L-arginine methyl ester prevented apomorphine to induce any response. It was concluded from the study that using a simple model of an awake model, it can be proven that apomorphine can induce an increase in the intracavernous pressure which can be maintained for prolonged duration of time due to sildenafil. This can prove that erectile dysfunction can be managed by the combination therapy of apomorphine and sildenafil. [3]

How Sildenafil Acts

The working of sildenafil citrate is dependent on its capability to cause hindrance in the way of phosphodiesterase type 5 enzyme. This enzyme is found in abundance in different parts of the body including the corpus cavernosum of the penis. PDE5 is involved in reducing the levels of cGMP from the body. cGMP is required by the body in a normal condition to combine with nitric oxide and produce an erection. Availability of PDE5 does not let this happen by breaking down all the cGMP in the penis. Sildenafil stops the working of PDE5 and lets cGMP gather in the penis to cause dilation of vessels. An increase in the total blood flow is observed in the penis and an erection is obtained. [4]

Nitro 50 mg Spray Effects for Erectile Dysfunction

Nitro 50 mg Spray can be used to treat a number of conditions as determined by a health care physician. The most important indication of this drug is the management of a failure to carry out a normal sexual activity. People who are suffering from a failure to continue a sexual intercourse due to the flaccidity of the penis can utilize this spray to get rid of the problem. The spray can enhance the overall standard of their life and make it more satisfactory and comfortable for both the patient and his partner. Moreover, the drug can also be used to treat pulmonary arterial hypertension. Nitro 50 mg Spray consists of sildenafil citrate that works to dilate the arteries of the lungs to lower down the high blood pressure and manage the pulmonary arterial hypertension. [5]

Suitable Doses and Scope of Therapy

Nitro 50 mg Spray must be only used orally. The best way to use this spray is to squirt it under the tongue which is rich with capillaries and other vessels. This ensures instant absorption of the drug by bypassing the digestive system and its enzyme. A user is expected to achieve successful results within a few minutes. The spray must not be used over and over again within 24 hours as an overdose of sildenafil can cause certain adverse effects within the body. The effects of a single spurt of Nitro 50 mg Spray are said to last for 1 hour to 1.5 hours. Drinking alcohol or consuming high lipid food can cause a delay in the onset of effects of this drug. [6]

Adverse Effects and Important Warnings

Side effects usually associated with this spray form of sildenafil include vomiting, nausea and diarrhea. Back pain and myalgia can also be reported by some patients who are using it for some time. The nose can become stuffy and the patient can encounter problems regarding his memory. Some serious side effects can also be caused by the use of Nitro 50 mg Spray which can include a sudden loss in auditory capacity of a person or ringing in the ears. Swelling can be seen in the hands and feet of the people using this spray in addition to vision changes, shortness of breath, irregular heartbeat and a heavy feeling in the chest. [7]

Contraindications

There are a number of drugs which must never be used in combination with Nitro 50 mg Sildenafil because of a risk of cross reactivity. The most prominent of these drugs are the nitrate drugs like nitroprusside which can cause an excessive drop in the BP of the person. Any drug that is used to treat angina or hypertension cannot be safe to use with Nitro Spray. Alpha blocking drugs, azole anti-fungal medication, macrolide antibiotics, HIV protease inhibitors and a lot of other drugs are inhibited to use with Nitro 50 mg Spray due to their risk of causing fatalities. [8]

Customer Reviews

Nitro 50 mg spray looks like a infamous drug because of an absence of reviews regarding it. Customer reviews are required for a particular drug to get an accurate estimate about its worth. These feedback reviews tell others about the authenticity of the drug and the legitimacy of the claims that a manufacturer has made in reference to it. Also because these drugs depict the experiences of actual customers who have personally tried the drug out, they are genuine and can be considered without any second thoughts. For drugs like Nitro Spray which fail to receive any customer reviews, it is most appropriate not to start using it blindly. The drug must be checked for safety and efficacy and if no data is retrieved, other drugs with similar active ingredients must be selected which are popular among the customers.

Price, Dosage, and Existing Forms

Nothing could be found in reference to Nitro 50 mg Spray on the internet. No pharmacy operating online is offering it for sale; therefore, nothing can be predicted about the price of this drug. Because Nitro Spray is facing issues regarding its availability, there is no shipping service offered for it as well. This means that customers dwelling in areas like America, Canada, Spain and Australia might find it hard to avail this drug.

Nitro 50 mg is manufactured as a spray only. It consists of sildenafil citrate as its active component which tends to fight erectile dysfunction forcefully. Patients suffering from erectile dysfunction are usually started off with 50 mg of sildenafil. These patients can be monitored for a few days to check their tolerance to this agent and the dose can be adjusted accordingly.

Conclusion with Rating

Nitro 50 mg spray has no existence on the internet at all. I personally think that the drug has failed to catch attention of any significant amount of customers, therefore, no one knows about it at all. I am not sure about how to use it or about the accurate dosage of this drug. No online pharmacy is selling it online hence; Nitro 50 mg spray is also facing an issue regarding its availability. Shipping service is also not offered for this spray. I could not know for certain whether it is a cheap or an expensive drug. No customer reviews exist that could guide me about Nitro Spray. All in all, I can say that considering Nitro 50 mg Spray as a remedy for erectile dysfunction and searching about it is a complete waste of time. I will give this drug 1 out of 5 and would definitely not recommend it to anyone who is suffering from erectile dysfunction.

Reference List

  1. https://en.wikipedia.org/wiki/AstraZeneca
  2. http://www.sciencedirect.com/science/article/pii/S0003497504005363
  3. http://www.sciencedirect.com/science/article/pii/S002253470569009X
  4. https://www.drugbank.ca/drugs/DB00203
  5. https://www.drugs.com/cdi/sildenafil.html
  6. http://www.indiatimes.com/news/world/the-man-who-invented-viagra-now-introduces-a-spray-to-get-you-going-in-matter-of-seconds-264607.html
  7. http://www.rxlist.com/viagra-side-effects-drug-center.htm
  8. http://www.webmd.com/drugs/2/drug-7418-589/sildenafil-oral/sildenafil-20-mg-lungs—oral/details#interactions
RxStars Review - 1 out of 5 stars by
RxStars