Napifit 100mg/75mg Tablet Sildenafil Review: Erectile Dysfunction Drug by GNP

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Napifit 100mg/75 mg tablets are used to overcome erectile dysfunction of almost all origins. The intake of this drug ensures a development of erection as well as maintenance of it for a prolonged duration. Napifit, therefore, enhances the quality of life and makes a person sexually satisfied. The drug is manufactured in the tablet form with sildenafil in the composition. Sildenafil is a PDE5 inhibitor and expands the vessels of the penis to provide the desired effects. Nausea, flushing, dyspepsia and a headache are some of the most commonly observed effects of Napifit. The drug must be stored away from sun and children.

About Global Napi Pharmaceuticals

Global Napi Pharmaceuticals was first established in 1997 and claims to provide high-quality medicines to its customers ever since. The company aims at fulfilling the needs of the doctors, pharmacists and the customers with efficiency. The company started off in Egypt providing its generic formulations to the local market. However, it has been successful in establishing different license agreements with other companies like Pfizer, MSD, Roche and Sanofi.

Global Napi Pharmaceuticals, Egypt

Global Napi Pharmaceuticals, Egypt

The products by the Global Napi Pharmaceuticals cover a wide range of therapeutic areas like endocrinology, dermatology, musculoskeletal system, respiratory system, antiallergic drugs, CVS drugs, medications related to gastroenterology and much more. More than 100 different drugs are produced by Global Napi Pharmaceuticals in different formulations like capsules, ointments, tablets, syrups, solutions gels and creams. [1]

Sildenafil in Clinical Studies

“Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension” by Ronald J. Oudiz et al is a study in which the use of sildenafil in improving the exercise tolerance and the ventilator efficiency in people was assessed. These people were diagnosed with pulmonary arterial hypertension and a consequent pulmonary vasculopathy. This pulmonary vasculopathy results in an enhanced resistance towards the flow of blood in the lungs. It also ensures a limitation of the cardiac output which is required to increase the demands of oxygen during exercise. In this study, the physiological basis of the treatment of pulmonary arterial hypertension was checked by administering sildenafil in them. It was hypothesized that an improvement in the ventilator efficiency and the flow of blood towards the lungs serve as the key factors in this improvement. Improvement in these factors would lead to an improved exercise capacity as well as the oxygen pulse over time. 28 patients suffering from pulmonary arterial hypertension were selected for this study. Out of these 28 patients, 14 were given sildenafil while the rest of the 14 patients were assessed without administering any sildenafil in them. All of the patients were given a treatment with warfarin as well as diuretics. 13 out of 14 patients who were being given sildenafil were also being treated with drugs for the treatment of pulmonary arterial hypertension. These patients were asked to indulge in a cardiopulmonary exercise both before as well as after the treatment. All of the parameters via which the patients were assessed were found to be improved in the patients who were being treated with sildenafil while there was a worsening seen in those who did not receive any sildenafil. It was concluded that the condition of patients suffering from pulmonary arterial hypertension improved by the administration of sildenafil. [2]

“Treatment of erectile dysfunction with sildenafil “by Leonard S Marks focused on all the aspects of treating an episode of erectile dysfunction with sildenafil. The main objective was to check the level of effectiveness of sildenafil in a clinical setting in the patients suffering from erectile dysfunction. The perceptions of the patients and their partners about the treatment were also correlated in this study. The severity of the erectile dysfunction and the level of response generated by the patient were also linked. A hundred men were selected in this study who were given sildenafil out of which 74 people completed the questionnaire given to them about their sexual health i.e. International Index of Erectile Function (IIEF). This questionnaire was given to them both before and after treating them with sildenafil for about 4 to 6 weeks. The same questionnaire was slightly modified and was given to the partners of these patients to fill. The disease of erectile dysfunction in these patients was categorized into 4 categories according to the severity. According to the question 3 and 4 of the IIEF, about 71 percent to 95 percent improvement was recorded in the erections of the patients consuming sildenafil. 77 percent of the total people wished to continue the treatment when the test trial was over. The score of the patients was compared with the results of the questionnaire filled up by their partners. It was seen that people suffering from class 1 erection problem responded much more as compared to those who did not achieve erections at all and were included in class 4. Patients who underwent a prostatectomy were refractory to sildenafil treatment. It was concluded from the questionnaire response that sildenafil is a great remedy for getting rid of erectile dysfunction. [3]

How Sildenafil Works

Sildenafil is a potent inhibitor of the famous enzyme- PDE5. This enzyme acts to work on the chemical messenger called as cGMP. PDE5 breaks down cGMP into phosphates and guanosine. As sildenafil is the potent inhibitor of PDE5, the levels of cGMP in specific areas increase which leads to the enhanced and prolonged action of this chemical messenger. cGMP acts on the smooth muscles of the penile arteries and acts on it to cause to strong vasodilating effect. As the vessels dilate, the blood to the penile organ is increased leading to stronger and prolonged erection. This erection stays as long as sildenafil remains in the blood. [4]

Napifit Benefits for Erectile Dysfunction

Napifit has sildenafil citrate which is a powerful agent for the fight against erectile dysfunction. By the virtue of this agent, the drug not only makes a patient achieve a rock solid erection but also keeps it for a period sufficient to carry out a sexual intercourse. Satisfaction level is increased and the patient regains his lost sexual desire. Both the patient and his partner can benefit from this drug in terms of pleasure. Premature ejaculation can be stopped and reaching the climax is made easy. Napifit can also be used to treat a condition of hypertension throughout the body due to its dilating action on the vessels. [5]

Recommendations for Doses and Length of Therapy

Recommended dose for most of the patient is 50 mg initially. Once the patient gets adjusted with Napifit, the dose can be increased or decreased by having a look at the severity of his erectile dysfunction. Napifit must be taken 30 minutes to 1 hour prior to a participation in sex. The maximum dose per day for this drug is one tablet. Napifit must only be taken orally with water and must be swallowed right in without chewing or crushing the tablet. Use of alcohol or high lipid meal is not recommended as they can lead to a decrease in the effectiveness of the drug. [6]

Side Reactions and Alerts

Some of the common side effects that can be experienced by the patients using Napifit include a headache, an upset stomach or diarrhea. The face, chest or the neck can become warm and flushed due to continuous use of Napifit. Patients might also experience a sudden change or a complete loss of vision in rare conditions. Similarly, ringing can be heard in the ears which can be followed by a loss in auditory capacity of the patient. The chest can become heavy and painful and this pain might radiate towards the shoulder or arm. The patient taking Napifit can feel nauseous or sick in general. Ankles, feet, and hands can undergo swelling and heartbeat can become irregular. Some people also experience shortness of breath while some feel like they might pass out. [7]

Drug Interactions

Some drugs taken by the patient possess an ability to interact with Napifit when taken concurrently. Therefore, it is always advised to consult a doctor before consuming this drug. Some of the drugs which can interact with Napifit tablets more commonly include alpha blocking drugs such as prazosin and the nitrates such as isosorbide dinitrate. Other drugs with a risk of cross-reactivity include azole anti-fungal drugs like itraconazole and histamine receptor antagonists like cimetidine. Macrolide antibiotics like clarithromycin and HIV protease inhibitors like ritonavir must also not be taken during a therapy with Napifit. [8]

Customer Reviews

No customer reviews exist for Napifit on any online website. This indicates that the drug has not been able to receive any attention from the customers. There is also no proof about the working and safety of Napifit. Such drugs are discouraged to be used because they possess a huge risk of causing adverse effects in the patients. The use of Napifit should be avoided and other alternatives must be searched for. A customer should preferably choose a drug with the same active ingredient but with a good reputation and confirmation about safety.

Cost, Market Forms and Suitable Dosage

Napifit can be purchased from a number of e-pharmacies operating online. One of such stores named agzakhana.com is offering Napifit in a pack of 4 tablets. Each drug has a potency of 75 mg and is priced at 1.270 US Dollars.

Napifit Price

Napifit Price

No shipping information is available about Napifit on the internet. None of the pharmacies are offering this drug for delivery to countries like America, Canada, and Australia. The drug can only be found in the local markets.

Napifit is manufactured in the tablets form only. It consists of sildenafil in 2 different strengths (75 mg and 100 mg). Sildenafil is started at a dose of 50 mg which can be increased or decreased later in accordance with the response of the patient. It is not advised to exceed the designated dose to avoid side effects.

Conclusion with Rating

I did not find Napifit as a competent drug since it lacks in so many aspects. It is a local drug of Egypt which is not much recognized throughout the world. The drug completely lacked in terms of user reviews so I cannot be sure of its reliability. The price of Napifit is quite low which goes in favor of this drug. However, no online store is offering delivery services for Napifit and customers can face a lot of problems while searching for it. Everything I could find out about Napifit is just assumed or claimed by the company and no evidence seems to be supporting these claims. Therefore, I would suggest the customers not to use Napifit and instead try out other drugs for erectile dysfunction. Napifit gets 1 out of 5 from my side for its poor performance.

Reference List

  1. http://www.globalnapi.com/SO/About.aspx
  2. http://onlinelibrary.wiley.com/doi/10.1016/j.ejheart.2007.06.013/full
  3. http://www.sciencedirect.com/science/article/pii/S0090429598005251
  4. http://www.vademecum.es/equivalencia-lista-napifit film-coated tablet 50 mg-egipto-g04be03-eg_1
  5. http://www.cphi-online.com/napifit-prod567263.html
  6. https://www.drugs.com/pro/viagra.html
  7. http://www.gmedication.com/?s=napifit
  8. http://www.ndrugs.com/?s=napifit&t=overdose
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