Intimax 100mg/50 Tablets Sildenafil Review: Male Enhancement not Safe to Be Used with Alcohol

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Intimax 100 mg/50mg tablets are designed to help in suffering from sexual dysfunction. The ingredients in it are used to revitalize and to revive a sexual life by providing the male a capability to obtain a rock hard erection. It also treats other problems described by a health care provider including pulmonary arterial hypertension. Intimax is manufactured in different forms like tablets, oral jelly, sprays, and pills. Side effects associated with this drug are nausea, vomiting, facial redness, and stomach upset. Changes in vision and hearing can also occur. Boys under 18 years should not use this drug. Females are not usually advised to consume Intimax tablets, even for pulmonary hypertension without consulting a doctor first.

About Agron Pharma India Pvt Ltd

Agron Pharma India Private Limited started operating in 1985 in the city of Kashipur, India. The company aims at improving the quality of drugs to enhance the living standards of people and help them live longer lives. Agron Pharma is among the oldest drug producing companies in Uttarakhand.

Agron Pharma, India

Agron Pharma, India

The company has been compliant with WHO GMP standards in addition to being IS) 9001:2009 certified. Different formulations of drugs are produced in the manufacturing plant of Agron Pharma which includes tablets, syrups, capsules, liquid orals, external preparations, liquid injections, dry powder injectables and much more. With an experience of over 40 years, the company has specialized in producing up to 500 different drugs. The company produces different over-the –counter drugs, several antibiotics, drugs related to respiratory system, NSAIDS, analgesics, etc. [1]

Scientific Publications on Sildenafil

“Evaluation of the safety of sildenafil for male erectile dysfunction: experience gained in general practice use in England in 1999” by A. Boshier et al discussed the safety of treatment with sildenafil in men with erectile dysfunction. Sildenafil citrate has been the first PDE 5 inhibitor that has been licensed to be used as a drug for treating erectile dysfunction. This study was performed to find out any adverse effects of sildenafil in patients who were treated with it. It was a cohort study based on observation and used a prescription –event monitoring (PEM). The patients who were prescribed sildenafil during a time period of April to August 1999 were selected and complete medical data about them was derived from the dispensed prescription details. Moreover, green forms questionnaires were used to check the outcome data which were returned by the general practitioners. 54.7 percent of the Green Forms submitted were returned to the general practitioners. Out of these, 22473 were having useful data about 22471 males and only two females. It was seen that in 73.8 percent of the people, the reason for prescribing sildenafil citrate was the emergence of impotence. In 0.8 percent, the agent was prescribed to treat the condition of diabetes mellitus. In 145 different events, people reported about developing complications due to the use of sildenafil. 3951 different reasons were recorded by the general practitioners for the drug withdrawal among which the condition of ischemic heart disease was found to be the commonest, prevailing in 135 different cases. The most frequently reported clinical condition during the first month of therapy was diabetes with or without hyperglycemia. 31.41 percent was the recorded ratio of the Standardized Mortality Rate for the deaths occurring due to the ischemic heart disease. The study concluded by rendering sildenafil citrate as an agent which is completely safe to use with no incidence of unexpected events in the population of England in 1998. [2]

“Duration of Action of Sildenafil Citrate in Men with Erectile Dysfunction” by Clive Gingell et al estimated the duration of action of sildenafil in men suffering from sexual dysfunction. It is known that sildenafil in the form of Viagra has a quick onset of action but nothing has been proven by far about the length of its duration of action. The study aimed at finding out about the duration of action of sildenafil precisely. The study involved a double-blind placebo-controlled trial including 16 men who were aged near 55 years. All of these men were suffering from erectile dysfunction of unknown causes. 100 mg sildenafil or equivalent amount of placebo was given to the test subjects at the intervals of 1 hour, 8 hours and 12 hours after which they were subjected to sexual stimulation. It was seen that at 1 hour of the interval, erections with more than 60 percent hardness were experienced for 26 minutes while at 8th and 12th hour, it was seen to last for 11 minutes and 8 minutes respectively. This duration was a lot more than that observed in people who received placebo. It was concluded from this study that the administration of sildenafil improved both self-assessed and objective sexual function in males as well as the duration of sildenafil. It was also said that the use of sildenafil can be effective up to 12 hours. [3]

Sildenafil Working Mechanism

Sildenafil belongs to a group of chemicals called as PDE5 inhibitors. They are called so as they block the activity of the enzyme phosphodiesterase type 5. Blocking this enzyme leads to the increased activity of cGMP in the smooth muscles and veins of the penis. cGMP causes the smooth muscles of the penis to relax, which leads to vasodilation and increased blood flow to the penis. As the blood flow in the penis increases, the erection is enhanced and the penis stays erect as long as sildenafil remains in the blood. [4]

Intimax Effects for Erectile Dysfunction

Intimax, just like Kamagra and Viagra, contains sildenafil as its main ingredient. As explained earlier, sildenafil acts to increase the blood flow to the penile organ causing an enhanced erection. This increased blood flow can be useful specifically for those who suffer from erectile dysfunction. Due to erectile dysfunction, the patients are unable to get an erection which can lead to poor quality of life and mental distress. Taking Intimax can reduce these symptoms resulting in a healthier sexual life. Not only does Intimax treats erectile dysfunction, it also cures premature ejaculation along with other male enhancement effects. By acting on some specific parts of the brain, Intimax also reduces the emergence of premature ejaculation. [5]

Suitable Doses and Length of Therapy

Every drug has a loading dose and a maintaining dose. A loading dose is an initial dose which is required to maintain therapeutic levels in the blood. The loading dose must be properly calculated so that the useful effects of the drugs start as quickly as possible. The loading dose of Intimax is 50mg. It means that during the start of treatment, the patient must take 50mg daily. After this, the maintenance doses start which are required to maintain the therapeutic levels in the blood for a long duration. The maintenance dose is 25-100mg per day. Patients are advised to take only one dose per day. [6]

Toxicities and Side Reactions

The side effects of sildenafil are widespread and can appear at different times during the therapy. The initial symptoms of toxic effects are facial flushing and warmth. The flushing and warmth can extend to the neck and even chest causing homeostatic problems. Stuffy nose and headache can occur after some time. Stomach pain and poor digestion is another problem related to sildenafil. Some other side effects include stuffy nose, nausea, diarrhea, memory problems, back pain, temporary color blindness, loss of hearing starting with ringing in the ears and dizziness.

It must be noted here that the effects of drugs are different for different people. It is not necessary that all of these side effects appear in almost every person. Some people face lesser side effects while others can face side effects not listed in this list. [7]

Drug Interactions

Sildenafil is notorious for its interactions with nitrates. Nitrates found in different drugs for cardiovascular disease can cause serious complications as nitrates and sildenafil both cause vasodilation. If both the drugs are given alongside, uncontrolled hypotension can occur, leading to vascular collapse and even bradycardia. All these symptoms lead to death.

Some other drugs that commonly cause interactions with sildenafil include cimetidine, bosentan, imatinib, nefazodone, clarithromycin, erythromycin, fluconazole, amlodipine, amiodarone and even ritonavir. Grapefruit juice is a potent inhibitor of hepatic enzyme p450, causing increased levels of sildenafil in the blood for a longer duration of time. Alcohol is also contraindicated with Intimax. [8]

Customer Reviews

Intimax did not seem to have received any kind of feedback from the customers’ side. All websites were completely devoid of any reviews made in this regard. The search for a review, in fact, became a daunting task in order to check the credibility of this medicine. For a drug like Intimax, it is not safe to use the pills before investigating more about the credibility. Therefore, users should use this drug at their own risk. Other credible drugs available in the market with the same active pharmaceutical ingredient should be preferred to it.

Cost, Forms, and Prescribed Amount

The Internet seems to be completely devoid of information regarding the price of Intimax 100 mg or 50 mg tablets. Thus, no estimates can be made about the price of Intimax i.e. whether it is an expensive drug or a cheap one. Likewise, there was not a single website present on the internet that was offering shipping services for this drug. This implies that Intimax might be facing an issue of availability and the only way of getting hands on this drug is to search for it in the nearby market which is quite hectic.

Intimax is manufactured in different forms including pills, oral jelly, tablets, and sprays. Each of these formulations consists of sildenafil citrate as the active ingredient. Sildenafil must be started at an initial dose of 50 mg per day while its maintenance dose ranges from 25 mg to 100 mg. Intimax must be taken once daily and overdose should be avoided to prevent side effects.

Conclusion with Rating

There is not much information about Intimax on the internet which can be used to deem it good or bad for use. The manufacturer of the drug has, however, claimed to have delivered a good treatment for erectile dysfunction in males. I could see that the manufacturing company of Intimax had received a good rating on the internet. However, it is not sufficient to render Intimax a good drug according to me. Furthermore, the pill itself has not received even a single customer review on the internet. This is an alarming situation which puts the authenticity of Intimax into question. Also, there is no information about the pricing and shipping of this drug on the internet. According to me, Intimax is not a popular drug among the customers and cannot be regarded as a promising one as well. I will give Intimax 1 star out of 5 possible and would not suggest it to anyone.

Reference List

  1. http://www.agronremedies.com/index.php?option=com_content&view=article&id=18&Itemid=75
  2. http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2003.04744.x/full
  3. http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2004.04026.x/full
  4. http://patient.info/medicine/sildenafil-for-erectile-dysfunction-nipatra-viagra-vizarsin
  5. https://www.drugs.com/dosage/sildenafil.html
  6. http://onlinelibrary.wiley.com/doi/10.1046/j.0306-5251.2001.00034.x/full
  7. http://www.penispillsadvice.com/side-effects-male-enhancement-pills/
  8. https://en.wikipedia.org/wiki/Sildenafil#Interactions

 

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