Filagra 100mg/50 mg gel is a renowned medicine for treating male sexual dysfunction. It is available in different forms which include tablets, soft pills, oral jelly and gel shots. Each form of Filagra consists of sildenafil citrate in different amounts to help males cope with difficulties faced in achieving and sustaining an erection. The pills can also be used to treat pulmonary arterial hypertension and other problems as directed by a healthcare provider. Minor side effects are associated with the use of Filagra including nausea, headache, and flushing of the skin. Filagra 100 is to be kept in a cool environment and away from children.
Centurion Laboratories Pvt. Ltd Profile
Centurion Laboratories Pvt. Ltd was first established in the year 2006. The company asserts that different kinds of high-quality pharmaceutical products are produced by it. All the drugs produced here are kept under the supervision of highly trained professionals after which they are packed in a hygienic and airtight packing.
Drugs produced by this pharmaceutical company are shipped to different areas of the world such as East Asia, South East Asia, Middle East, Indian Subcontinent, and East Europe. Centurion Laboratories are located in Gujarat, India and over 100 to 500 employees work here. The company aspires to be the most valued pharmaceutical business in India. Drugs produced by this company include antiseptics, anti-allergics, pain killers, antibiotics, anti-psychotic drugs and much more. 
Studies on Sildenafil
“Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress” is the name of a study conducted by Trinity J. Bivalacqua et al in which the role of sildenafil in controlling priapism in mice was established. Sildenafil citrate was first approved by the Food and Drug Authority 15 years ago as a drug for treating issues related to sexual health. It is a prototype agent which inhibits the activity of phosphodiesterase type 5 and helps a man get rid of issues related to erectile dysfunction. It has also been investigated for its clinical benefits in the treatment of priapism. Priapism is a disorder related to the sexual function of males in which the sufferer experiences uncontrolled erections of the penis for a long duration of time. Mice were selected as the experimental animals in this scientific trial. These mice were showing symptoms of priapism in addition to suffering from sickle cell disease. Sildenafil was ingested in these experimental mice and results were recorded. It was seen that administration of sildenafil reversed the oxidative or the nitrosative stress in the penis of these mice. This reversal of the oxidative stress was thought to be due to the transformation of the uncoupled inactivated form of endothelial nitric oxide synthase enzyme into the coupled state of this enzyme which was fully functional. This activated form of nitric oxide synthase, in turn, corrected the deviant signaling and the abnormal function of the cascade including cyclic GMP, nitric oxide, phosphodiesterase 5 and the protein kinase G. Following this mechanism, the tendencies of priapism in the experimental mice were partially regressed in a direction of normal and neurostimulation frequencies and durations of the erections. This was aided by a normalization of the cGMP concentration, restoration of the activity of protein kinase G and that of phosphodiesterase type 5. It was concluded that sildenafil has pleiotropic effects on the penis which can treat a variety of disorders related to erection. 
“Management of sildenafil treatment failures” by Kendirci et al discussed the alternative options if treatment will sildenafil fails to work in a patient. Oral PDE5 inhibitors are said to be the first line of therapy for erectile dysfunction because of great efficacy and ease of using. However, there are a number of people who do not respond to this treatment because they are suffering from end-organ failure. Failure of sildenafil can be attributed to a lack of effectiveness or side effects and the issues can revolve around a patient, his partner, and the physician. Physicians play a role in sildenafil failure by providing inadequate knowledge, no follow ups, no sufficient trials, a lack of clarification regarding safety and suboptimal dosing of the patient. It was discussed in the research that by carefully optimizing the dose, providing the patient with counseling and modifying the risk factors associated with sildenafil therapy can help people respond to sildenafil who initially failed in doing so. Moreover, other treatment options for ED can also be considered which include the use of vasoactive drugs via an intracavernosal or intraurethral route or the use of vacuum devices. The penile prosthesis can be considered as the last option of treatment when all other therapies fail. 
Sildenafil in Action
Filagra, just like Lovegra and Kamagra, maintains sildenafil Citrate as one of the primary ingredients. Just like Cialis, the basic purpose of sildenafil is to discharge nitric oxide (NO) within the corpus cavernosum of the copulatory organ. It is, in fact, a powerful formula that serves as an inhibitor of cGMP specific Phosphodiesterase 5 enzyme. This causes a breakdown of the cyclic Guanosine Monophosphate in the musculature of the penis. On the other hand, cyclic Guanosine Monophosphate (cGMP) works as a potent regulator and supervises the function of producing relaxation within the tissues and smooth muscles of the penis. The presence of sildenafil citrate hinders PDE5 from crushing the cGMP which consequently enables a person to experience a normal sexual stimulation. A stronger and firmer erection is ensured in this way. It must be remembered that sexual stimulation must already be present in order for sildenafil to work its best. 
Filagra Benefits for Erectile Dysfunction
The super active Filagra is specially formulated in different compositions and strengths to tackle all the possible problems encountered by males. It is a new generation sildenafil loaded drug which has a strong formula to combat repeated failures in attaining an erection and keeping it for a sufficient period of time. It also treats the problem of premature ejaculation as well as flaccid erections. Filagra helps to get rid of erectile failures from the core. It improves the sensations and feelings during a sexual activity and also tends to improve the overall quality of sex. It becomes easy to reach the climax and have enhanced orgasms by just using this pill. Filagra 100 is also available in the form of fruit chews and oral jelly for people who cannot use tablets. It is also available in extra strength as Filagra extra power which takes lesser time to act. 
How to Take Filagra and How Long does it Last
Filagra pills or oral jelly should always be ingested via the mouth. It can be taken between 30 minutes to 4 hours before participating in an intercourse. Filagra is, however, more effective if taken up tone hour before a sexual activity. It is not advised to take more than one dose of Filagra per day. Consuming heavy meals of lipid-rich food can cause a delay in the onset of its mechanism. Similarly, alcoholic brews should be abstained from while a patient is on a therapy with Filagra. The answer to a common question i.e. how long does it last is 4 to 5 hours. 
Adverse Reactions and Warnings
Use of Filagra is associated with some minor side effects like feeling nauseated, experiencing a headache and stomach upset. Other complaints like stuffy nose, palpitations of the heart, tenderness of the stomach and pain in bladder have also been reported. Filagra is also capable of producing visionary changes which include blurry eyesight and a partial or complete loss of eyesight. Fever, drowsiness and chills can also accompany. Cold sweat, double vision, and tingling in ears are some less commonly observed side effects of Filagra. Skin usually flushes and becomes red and the patient finds it difficult to sleep while continuing therapy with Filagra. 
Filagra with other Drugs
Filagra must never be taken with alpha blocking drugs like Doxazosin which can cause a severe drop in blood pressure and dizziness. Redness of face can occur if Filagra is used with azole anti-fungal drugs like Ketoconazole and Itraconazole. People who are on a therapy with recreational drugs and poppers like amyl nitrites should never take Filagra. Nitrates for treating heart problems like nitroglycerin should also not be used with this drug. Drugs belonging to the category of Barbiturates, for example, Phenobarbital can reduce the efficacy of Filagra when used along with it. Other warnings for using Filagra include not using other drugs mean for treating ED at the same time. 
Filagra has received a number of customer reviews, mostly positive. A 46-year-old customer called it “amazing” and said that Filagra helped to make his erections hard. He felt youthful, all thanks to Filagra. Robert suffered from erectile dysfunction and tried Filagra out but did not find it as effective as other pills meant for the same purpose.
Richard who was suffering from a lack of testosterone was prescribed Filagra. He mentioned in his review how Filagra gave him strong erections and he managed to maintain it without facing any kind of trouble. 46-year-old Robert was very pleased with Filagra which provided him with excellent results.
Richard Donnell who had been taking Filagra for 6 months shared his thoughts that he was amazed at the results it provided.
Price, Market Forms, and Suitable Dosage
Interested customers can purchase Filagra from a number of online stores. The drug is quite cheap with a unit price of 0.80 USD for 50 mg strength. If a customer buys more than 40 tablets of Filagra, the unit price further decreases and allows the person to avail a discount.
The medicine is also up for shipping via two different methods. Normal shipping requires 8 to 12 working days to reach its destination and charges 25 USD. Express Shipping needs 3 to 7 days and charges 100 USD.
Filagra is formulated in hard tablets, gel shots, oral jelly and chewable form of pills. A doctor should be consulted for deciding about the accurate dose of sildenafil which varies from patient to patient. However, it is a usual practice to consume one dose per 24 hours to avoid side effects.
Conclusion and Rating
Filagra is manufactured by Centurion Laboratories Private Limited and can be called as a miracle pill for the patients suffering from erectile dysfunction. It consists of Sildenafil Citrate as an active ingredient and works just like a standard Viagra. I also found it as a remedy for relieving patients suffering from pulmonary hypertension. There are a few minor side effects which Filagra 100 is capable of causing but that cannot stop it from being an extremely effective drug for ED. I gathered a lot of user reviews regarding Filagra in which most of the customers were quite happy with the performance. The manufacturer of Filagra 100 is also a reputed company, therefore, I cannot question the reliability of Filagra. Hence, I would give Filagra 100 5 out of 5 stars for being a useful and economical medicine to treat sexual dysfunction in males.