ENAGRA Tablet Osho Review: Low-Cost Sildenafil Drug from India

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Enagra 50 mg Sildenafil Citrate tablet is another Indian-generic made product meant for the treatment of erectile dysfunction. There is an overabundance of generic PDE5 (Phosphodiesterase Type 5) inhibitor products created for impotence treatment, although the approvals for the generic Sildenafil products for erectile dysfunction is not for until a few years. Apparently, the Viagra patent has expired earlier in other countries of the world.

The PDE5 inhibitors such as Sildenafil Citrate are effective in the oral management of the impotence condition which a large part of the male population suffers from [1]. However, men who are without erectile dysfunction often use the product for recreational purposes, which complicate the effect of the ingredient in the patients. The use of Sildenafil Citrate should be strictly on a prescription basis alone since there is a plethora of considerations to establish the safety of the use of the product in the patients [2].

Enagra is available in the market in tablet form and in doses of 50 mg/100 mg [3,4]. The product is manufactured by the company Osho, which is located in India, and another contributor in the growing industry of Indian pharmaceutical products.

About Osho Pharma Pvt.Ltd

Since its inception in 1980, Osho Pharma Pvt. Ltd. had been engaged in the manufacture, distribution, and export of pharmaceutical products in the areas of general medicine, vitamins, food supplements, antibiotics, antibacterial products, cold/flu meds, herbal medications, cough syrups, anti-inflammatory products, antipyretics, ulcer, cardiac medicines, and psychiatric remedies [5].

Based on the available information for the company, Osho Pharma has 250 products registered under its name [5]. Besides producing its own products, the company is also known for engaging in other P2P manufacturing, contract manufacturing and research, product formulation development, and other services [5].

Osho Pharma Location

Osho Pharma Location

Osho is ISO 9001:2000 accredited, and its facility is certified by the World Health Organization for Good Manufacturing Practices [6]. As mentioned on the company’s website, its herbal goods in tablet, capsule, liquid, ointment, and oil forms are produced in a distinct facility as prescribed by the “Schedule T” for herbal product manufacturing.

Scientific Studies on Sildenafil

The PDE5 (phosphodiesterase type-5) inhibitor, Sildenafil Citrate, was first used in the treatment of angina pectoris and was only discovered by accident for the management of erectile dysfunction. However, there were studies conducted for the use of the Sildenafil for the functional exercise capacity and endothelial function of patients diagnosed with chronic heart failure (CHF), as the PDE5 enzyme is found in the visceral muscles too. The research of Guazzi et al, “Long-Term Use of Sildenafil in the Therapeutic Management of Heart Failure” in 2007 focused on the outcome of the chronic use of Sildenafil Citrate for the improvement of the exercise capacity of patients with CHF, on the premise that PDE5 inhibition by Sildenafil is beneficial in the amelioration of endothelial function in patients [7]. Patients with stable CHF conditions were randomized to either 50 mg of Sildenafil (23 patients) or placebo (23 patients), twice a day, concurrent with their other medications [7]. The patients were assessed 3 and 6 months into treatment for their developments [7]. The results of the study indicated that Sildenafil Citrate is able to improve exercise ventilation and aerobic efficiency, as well as sustain the effect in patients [7]. The authors concluded that chronic Sildenafil administration is a well-tolerated and an effective option for increasing exercise capacity for patients with CHF [7].

McCullough et al, in their paper, “Achieving treatment optimization with sildenafil citrate (Viagra®) in patients with erectile dysfunction1” expounded on Sildenafil Citrate and its dose optimization in patients [8]. According to the authors, since Viagra (Sildenafil Citrate) was approved in 1998, more than a 100 trials involving 8000+ men with erectile dysfunction proved that the product for impotence is efficacious, although there are dose-optimization notes which should be considered by the general health practitioners for patients to continue with their treatments [8]. According to McCulllough et al, the treatments with Sildenafil can have greater success when these are considered: intercourse success with the use of Sildenafil increased with the number of attempts, a more comprehensive approach to ED management including medical history/physical exams/other materials can lead to more treatment success, routine questioning about ED symptoms by the doctors should be done, re-education and counseling (proper drug intake) are essential to achieving treatment success for failed treatment attempts, proper screening for the meds taken by patients with comorbid diseases is imperative to increase intercourse success rate, and that treatment satisfaction is paramount in maintaining a long-term ED treatments in patients [8]. All of these factors, when taken into consideration can help largely in the realization of all the ED treatment goals in the patients [8].

Sildenafil Action Explained

The drug Sildenafil Citrate helps the patients attain and maintain an erection by inhibiting the very enzyme which prevents the action of the cGMP (cyclic guanosine monophosphate), the nucleotide which induces the vasodilation and the smooth muscle cell relaxation in the penile area.

PDE5 inhibitors such as Sildenafil Citrate help the initiation of the erectile reaction by encouraging the increase and the maintenance of the cGMP levels in the penile corpus cavernosum. Cyclic GMP is the one responsible for the commencement of the erectile mechanism, which makes its presence essential in the penile tissues. Sildenafil Citrate is able to suppress the action of the PDE5 enzyme and prevents the enzyme from disintegrating the cGMP essential to the erectile response in patients with impotence.

Enagra 50 mg Effects for Erectile Dysfunction

Sildenafil Citrate products are successful treatments for patients diagnosed with erectile problems. Enagra 50 mg, since it has the valuable active ingredient, Sildenafil, can also be reckoned as effective for the management of the dysfunction. Enagra is only indicated for the treatment of impotence in males, although its Sildenafil Citrate content has the capacity for so much more. Currently, approved conditions for the use of Sildenafil include pulmonary hypertension and lower urinary tract symptoms in patients with non-cancerous hypertrophy of the prostate, and presently, there are numerous studies considering further applications of Sildenafil beyond the approved FDA uses of the drug.

Recommended Doses and Duration of Therapy

The 50 mg dose formulation of Edegra is the initially prescribed treatment for erectile dysfunction patients, although the dose is typically adjusted to provide optimal benefits for the patients. Sildenafil Citrate merchandises are recommended to be taken at least an hour before the intercourse and regardless of the dosage, there is a limit of a single dose of the drug per day in order to forestall adverse events.

Side effects and Warnings

Likely side effects determined even for the acute use of Sildenafil Citrate items such as Enagra are indigestion, visual disorders, dizziness, headaches, stuffy or blocked nose, and facial redness [9]. As per product information on Edegra, these described events are conceivable but do not happen 100% of the time. Still, patients should watch out for the side effects and seek medical help when they deem relevant.

Drug Interactions

Drug interactions are also likely for Sildenafil Citrate. In fact, there are a number of medication interactions identified for Sildenafil. Drugs such as Amlodipine, Amyl Nitrate, Cimetidine, Doxazosin, Erythromycin, Nitrates, and other drugs belonging to similar drug categories are contraindicated for Sildenafil [10]. These medical products can either counteract the effect of Sildenafil or enhance the effect of the drug, which are both not beneficial effects for the patients.

Customer Reviews

Consumer reviews are highly beneficial markers of drug efficacy and safety whenever available. Often, other users tend to base their purchase behaviors upon the reviews available for a product they intend to buy, and often go for the brands with higher ratings. This is the same with pharmaceutical products too. Buyers tend to gravitate towards the items which are not necessarily the “best”, but those which have larger consumer review volumes available.

We cannot tell for sure if Enagra tablets are effective agents for the treatment of erectile dysfunction, but the absence of the reviews thereof is not helping for the brand. Enagra may be the best generic Viagra product out in the market, but since there are no users to testify of its integrity, doubts for the brand effectiveness will continue to surround the product, unless good feedbacks for the brand surface in the near future.

Price, Available Forms and Dosage

Though Enagra comes in 50 mg and 100 mg forms, only the 100 mg variant has an available price quotation from one of the online websites selling the product:

Enagra Cost

Enagra Cost

Based on the Gmedication.com product rate for Enagra (Osho) in the 100 mg form, the product costs $1.48 for 4 tablets. The price is very affordable since the product is only sold for less than a dollar each, which is far lower than the price of the brand-name Sildenafil treatment for impotence. The 4 for $1.48 pricing is also generally more affordable than most of the generic Sildenafil treatments in the market.

Since there were no voiced restrictions for the international shipment of Enagra, the drug is shipped to buyers from the USA, Australia, and Canada, although restrictions still may apply to the US, due to the patent protection of Viagra in the country. Buyers should be made aware of the legalities for the sale and distribution of generic erectile dysfunction treatments in their countries so that they become sentient of the risks of importing their impotence drugs online.

Conclusion and Rating

Enagra Tablet by Osho Pharma Pvt. Ltd. is one of the most affordable erectile dysfunction drugs in the online market place. It is super affordable for the general public and it is readily available online for local and international buyers alike. However, there were no product reviews for Enagra, which makes the drug highly doubtful. Qualms for the drug’s effectiveness are raised due to the lack of reviews for the product, so we can only rate Enagra 2 out of 5. Sure, it is still recommendable to a certain degree, but only under the counsel of your doctors. If your doctor approves Enagra, then it is considerable to use, but otherwise, it is not.

Reference List

  1. http://www.bumc.bu.edu/sexualmedicine/publications/new-oral-agents-for-erectile-dysfunction/
  2. https://www.dred.com/uk/viagra-without-prescription.html
  3. http://www.genericdrugscan.com/brand/enagra+(50+mg)
  4. http://www.medindia.net/drug-price/sildanafil/enagra-100-mg.htm
  5. https://www.indiamart.com/osho-pharma/profile.html
  6. http://www.oshopharma.com/accre.html
  7. http://www.sciencedirect.com/science/article/pii/S0735109707028501
  8. http://www.sciencedirect.com/science/article/pii/S0090429502016886
  9. http://www.tabletwise.com/enagra-tablet
  10. http://www.tabletwise.com/enagra-tablet/interactions
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