Edegra 50mg/100mg Pills Sun Pharma Reviews: Low Price Impotence Product

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Edegra 50 mg/100mg tablets are made up of the active pharmaceutical ingredient Sildenafil Citrate, which is the primary ingredient of the famed impotence treatment, Viagra. These two drugs are the same in terms of active ingredient content, although they only differ mostly in their manufacturing companies and their cost, as the generic Viagra (Edegra) costs more economical than the brand-name Viagra.

Both Edegra 50mg/100mg and Viagra are classified under the drug umbrella of PDE5 inhibitors or Phosphodiesterase Type-5 inhibitors which are mainly drugs for erectile dysfunction (ED) in males [1], although these PDE-5/PDE5 inhibitors are also used in other applications. PDE5 inhibitors like Sildenafil Citrate-containing medications are also US Food and Drug Administration-approved treatments for pulmonary arterial hypertension in both adults and the pediatric patient population, as well as for urinary retention in patients with benign prostate enlargement [2].

Sun Rise International Labs Ltd. introduced the drug in the local Indian market in the year 2001 and the drug was modeled after its brand-name predecessor, Viagra [3]. Three dosage strengths are available for the product, 25 mg, 50 mg, and 100 mg [3]. According to the press information, Edegra is a “schedule H” drug which requires several prescriptions before its dispensation [3]. As a schedule H drug, patients should have prescriptions from their psychiatrist, urologist, and endocrinologist before the product is released to the patients [3]

About Sun Rise International Labs Ltd

Sun Rise International Labs Ltd. is one of the pharmaceutical companies located in Hyderabad, in India [4]. The company is a subsidiary of the larger enterprise, Perdaman Pharmaceuticals, which is also located in the country [4]. The company is incepted in the year 1986, and according to the company information on the web, the company is proficient in drug delivery systems [4].

Sun Rise International On a Map

Sun Rise International On a Map

The company, Sun Rise Labs, has a production capability of 30 million tablets, 10 million capsules, and 1 million oral liquid bottles per month [5]. These products are made for various therapeutic areas such as anti-infectives, GI, analgesics, musculoskeletal, nutraceuticals, erectile dysfunction, anti-diabetics, tuberculosis, allergies, cardiovascular, malaria, and others. Sun Rise Labs can manufacture various pharmaceutical products in several product forms which include dry syrups, injections, soft gel capsules, FFS tech-based formulations, and the traditional tablets, capsules, liquid orals, and effervescent tablets [6]. Currently, Sun Rise Laboratories is WHO-GMP certified [4].

Clinical Research on Sildenafil

Not only is Sildenafil Citrate used for the treatment of erectile dysfunction, it is also considered a mode of therapy for infants suffering from pulmonary hypertension. Mourani et al’s study, “Effects of Long-Term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease”, studied the long-term effects of Sildenafil treatment in patients with chronic lung disease (CLD) [6]. Infants aged below 2 (25) with CLD were included in the study [6]. These infants were treated with Sildenafil for pulmonary hypertension from 2004 to 2007 [6]. According to the investigation, 22 patients were able to improve hemodynamically after a treatment duration of 40 days [6]. 5 of the patients died during the follow-up, and there were cessations of therapy due to side effects (2 patients) and one for the recurrent erections [6]. The researchers concluded that overall, Sildenafil treatment is well-tolerated and safe to use even by infants diagnosed with CLD and pulmonary hypertension [6].

Long-term effects of Sildenafil Citrate are also assessed in patients treated with Sildenafil Citrate for their erectile dysfunction after their radical prostatectomy (RP). The study of Raina et al, “Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up1” in 2002 is one of the studies which evaluated the long-term effect of Sildenafil in patients [7]. 91 patients were included in the investigation and were administered with Sildenafil Citrate (50 mg to 100 mg, as needed) post their radical prostatectomy [7]. 43 patients responded well to treatment, and after 3 years, 31/43 patients were still responding to Sildenafil. 31% of the patients had doses amplified to 100 mg. The dropout rate, according to the results of the study was 27%; surprisingly, 6 out of 12 discontinued due to the reoccurrence of natural erections of the patients, 5 halted therapy due to ineffectiveness, and 1 due to the death of his spouse [7]. Within 3 years, adverse events determined were headaches in 12%, flushing in 10%, and blue-tinged vision or blurred vision in the patients [7]. However, no patient discontinued therapy due to the presence of the side effects [7]. The researchers concluded that patients post RP who were able to respond promptly to Sildenafil continued to respond to Sildenafil after 3 years of treatment [7]. All in all, patients were satisfied with the Sildenafil administration [7].

Sildenafil Mode of Action

Sildenafil Citrate, in a nutshell, is able to increase vasodilation and direct the blood flow to the corpus cavernosum of the penis. Aside from that, the drug is also able to command smooth muscle relaxation in the penile walls, which leads to an erection. This erectile action of Sildenafil citrate can be attributed to its capacity to supersede the effect of the PDE5 enzyme (that’s why Sildenafil is called a PDE5 inhibitor). Sildenafil Citrate subdues the effect of the PDE5 enzyme so that it won’t degrade the cGMP (cyclic guanosine monophosphate), which ensures the vasodilation and the smooth muscle relaxation necessary in the erectile response.

Edegra 50mg/100mg Benefits for Erectile Dysfunction

Edegra 50mg/100mg is solely intended for erectile dysfunction, although its Sildenafil Citrate content is used for other applications other than impotence. Sildenafil Citrate is also used in the management of pulmonary hypertension in patients [2,7], although the primary indication for the drug and the use it is known for is for the management of erectile dysfunction. Patients can expect the improvement of their erectile function with the use of Sildenafil, as the drug is efficacious in eliciting the response in the patients.

Suitable Doses and Extent of Therapy

Primary recommendation for Sildenafil dose for the treatment of erectile dysfunction is 50 mg to 100 mg, depending on the patient tolerance for the medication. In more severe cases, though, Sildenafil Citrate is recommended in doses more than 100 mg, as the patients are able to tolerate and as long as the side effects are tolerable enough.

Only one dose in a 24-hour period is advisable for the patients, in order to lessen the appearance of the side effects. Sildenafil Citrate is more effective when taken without food, about 30 minutes to an hour prior to the scheduled intercourse. Although there is less spontaneity with the use of Sildenafil Citrate, the drug is still useful for patients who wish to improve their erectile response due to their impotence condition.

Adverse Reactions and Important Warnings

Side effects observed for Sildenafil Citrate use are headache, facial flushing, muscle pain, dizziness, shortness of breath, and epistaxis [8]. These side effects do not last long, and they are quite manageable. Adverse events do not occur very often; in one of the studies, the incidence of the minor side effects determined for Sildenafil Citrate use is 12% [7], which is not really a large chunk of the patient population administered with the drug. But when these side effects last more than they are supposed to, or if they contribute to the degeneration of a patient’s health, then these side effects should be duly reported to the physicians for medical advice.

Drug Interactions

The reason why Edegra, generic Viagra products, Viagra and other Sildenafil Citrate-containing products are prescription medications is their possible drug interactions. Current meds of the patients which are scheduled to take Sildenafil should be evaluated thoroughly by the doctors in order to rule out possible harmful drug interactions for Sildenafil. Drugs families which may interact with Sildenafil are Nitrates, Antifungal meds, Anti-bacterial medicines, Antibiotics, and Anti-viral medications. Also, grapefruit juice and alcohol are not advised to be taken with Sildenafil Citrate. Any Sildenafil Citrate drug must also not be taken with other PDE5 inhibitors, in order to avert plausible complications, especially the adverse events.

Customer Reviews

A few client testimonials were available for Edegra 50mg/100mg on the web, and these comments were mostly from impressed clients:

Edegra Feedback

Edegra Feedback

Michael Thompson from California mentioned that he had an “impressive” erection. He appreciated the fact that the oral pill is able to do its job and he preferred Edegra over his previous “injections”.

Another client, Grayson Martin, cited that he had “fast results” from his Edegra use, and also described his wife’s satisfaction from the product as well. The buyer stated how his sexual life was able to vastly improve with the use of Edegra.

Although the comments for the product were good, these are only a fraction of the total comments for the product and do not reflect the entirety of the performance of Edegra. However, it is good to see positive comments for the product and not complaints from disappointed users.

Price, Existing Forms and Available Dosage

The available formulations for Edegra are 25 mg, 50 mg, and 100 mg, although the commonly sold product formulation is 100 mg.

Edegra Pricing

Edegra Pricing

Viagradoc.com lists Edegra 100 mg at $21 for 30 pills, which makes each unit only $0.70. The product price also goes lower, at $0.57 each when purchased for at least 70 pills; the price per unit of the product goes down as quantity bought gets larger.

Edegra Shipping Cost

Edegra Shipping Cost

Product shipping to various parts of the world, like the USA, Australia, and Canada. The costs for the shipping are standard, and there is no variation in the shipping costs regardless of the destination, although the buyers can choose slower or swifter shipping options (courier). Postage fee is either $17 or $24 and the buyers are the ones to choose which courier works best for them.

Conclusion with Rating

Edegra 50mg/100mg manufactured by Sun Rise Laboratories is one of the cheapest generic Viagra products in the online market. The present review for the drug showed that the users are generally happy with the results of the drug for their impotence. However, it should be better if the reviews were from review sites and forum sites, where the reviews are more reliable. The maker of Edegra is certified by the WHO-GMP, which makes it reliable quality-wise. The rating for the product is 3 out of 5; Edegra is a cheap Viagra alternative, and it is recommendable only when your doctors approve the use of this product for your erectile dysfunction condition.

Reference List:

  1. Sexualhealthaustralia.com.au: PDE5 Inhibitors (Viagra, Cialis, Levitra). Obtained from: http://www.sexualhealthaustralia.com.au/pde5_inhibitors1.html
  2. Phauk.org: treatment for Pulmonary Hypertension. Obtained from: http://www.phauk.org/treatment-for-pulmonary-hypertension/phosphodiesterase-5-inhibitors/
  3. Thehindubusinessline.com: Sun Pharma launches Edegra. Obtained from: http://www.thehindubusinessline.com/2001/01/18/stories/021851pc.htm
  4. Sunriseintlabs.com: Home. Obtained from: http://www.sunriseintlabs.com/index.html
  5. Sunriseintlabs.com: MANUFACTURING FACILITIES. Obtained from: http://www.sunriseintlabs.com/manufacturing_facilities.html
  6. Mourani PM, Sontag MK, Ivy DD, Abman SH. Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease. The Journal of pediatrics. 2009 Mar 31; 154(3):379-84. Obtained from: http://www.jpeds.com/article/S0022-3476(08)00785-3/abstract
  7. Raina R, Agarwal A, Lakin MM, Sharma R, Zippe CD, Montague DK, Goyal KK, Klein E. Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up. Urology. 2003 Jul 31; 62(1):110-5. Obtained from: http://www.sciencedirect.com/science/article/pii/S0090429503001572
  8. 1mg.com: EDEGRA 100 MG TABLET. Obtained from: https://www.1mg.com/drugs/edegra-100-mg-tablet-32662
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