Dynafil 50mg/100mg Tablets Pharma Dynamics Review: Impotence Drug Contraindicated with Alcohol

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Dynafil 50mg/100mg tablets are the products of Pharma Dynamics, which is one of the subsidiaries of the company Lupin Pharmaceuticals in South Africa. Dynafil contains the active pharmaceutical ingredient Sildenafil Citrate, which is a PDE5 (phosphodiesterase type-5) inhibitor drug used in the oral management of the symptoms of impotence in patients. The PDE5 inhibitor family is where the famous drugs for erectile dysfunction Viagra and Cialis belong to [1]. Viagra belongs to the Sildenafil family, like Dynafil, while Cialis belongs to the Tadalafil group. Dynafil is one of the generic Viagra products available in the market, which means consumers can expect a lower price for these tablets than the brand-name Viagra.

This product, Dynafil is sold by the company in the regular pill and tablet forms and is only manufactured in 25 mg, 50 mg, and 100 mg doses [2]. Like the traditional Sildenafil products, the intake for Dynafil is limited to one dose per day. The recommendation for the intake of Dynafil is 30 minutes before the planned intercourse, as the drug only takes effect in 30-60 minutes post ingestion. Although a lot of users tend to use Sildenafil product as an aphrodisiac, Sildenafil-containing products are actually prescription meds which are not to be used for recreational purposes [3].

About Pharma Dynamics

The company Pharma Dynamics is a pharmaceutical enterprise situated in Cape Town in South Africa and founded by Paul Anley in the year 2001 [4]. Pharma Dynamics is prominent for its cardiovascular (CVS) products, as according to Pharma Dynamics, their CVS products continue to be the “most prescribed portfolio” when it comes to cardiovascular diseases and other heart conditions in South Africa [4].

Besides the CVS products, though, the enterprise also produces pharmaceutical merchandise in the areas of pediatrics, central nervous system, and over-the-counter products for colds, flu, allergies, immune boosters, and heartburn [4]. Critical care products are also the concern of the company, as it is able to provide its hospital clients with intensive care antibiotics, along with specialty products for men and women’s health.

Pharma Dynamics Location

Pharma Dynamics Location

In South Africa, Pharma Dynamics is the 4th largest generic company, and the number 1 CVS company in the country [4]. It also prides itself in helping its clients save up to 50% of their healthcare costs due to the affordability of the company’s products [4].

Today, Pharma Dynamics is wholly possessed by the company Lupin Pharmaceuticals, which is one of the major players in the global pharmaceutical industry [4]. Besides being owned by one of the world’s largest companies, Pharma Dynamics even has partnerships with 16 manufacturing names in the pharmaceutical industry, which are all approved by either the US FDA, South Africa MCC (Medicines Control Council), UK MHRA, Australia TGA, or the EU EMEA [5].

Scientific Studies on Sildenafil

Non-arteritic anterior ischaemic optic neuropathy (NAION) is one of the rare adverse events observed in patients taking PDE5 (Phosphodiesterase Type-5) inhibitors. The paper of McGwin et al in 2006 determined the association of Viagra (Sildenafil) and Cialis (Tadalafil) to the rare optical adverse event NAION in patients (“Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction”) [6]. 38 cases of males with NAION were studied by the authors and were matched with 38 control males without NAION history and were evaluated for their past use of Viagra or Cialis [6]. As per study’s results, there was no statistical significance observed in the patients with NAION and their past Viagra or Cialis use, but the authors mentioned that patients with monocular NAION may have increased susceptibility to NAION with the use of either Viagra or Cialis by patients [6]. Also, although there is no established link between NAION and Viagra or Cialis use, patients with a history of myocardial infarction or hypertension will have an increased risk for NAION should they use the PDE5 inhibitors Viagra and Cialis [6].

The study of Jannini et al in 2009, “The ENDOTRIAL Study: A Spontaneous, Open-Label, Randomized, Multicenter, Crossover Study on the Efficacy of Sildenafil, Tadalafil, and Vardenafil in the Treatment of Erectile Dysfunction” determined the effectiveness of the 3 brand-name treatments for erectile dysfunction (Viagra, Cialis, and Levitra) and randomly assigned them to patients within 8 weeks [7]. Patients were grouped into 4 and made to take either 100 mg Sildenafil, 50 mg Sildenafil, 20 mg Tadalafil, or 20 mg Vardenafil [7]. All of the patients were improved significantly by all medications as observed in their abridged International Index of Erectile Function (IIEF+1) scores [7]. Although there was an overall equivalence in the erectile improvement functions of all medications, Sildenafil (dose-dependent) was able to amend the penile flow parameters of the patients in the trial period [7].

Since the PDE5 inhibitors such as Sildenafil (Viagra) and Tadalafil (Cialis) have their effects exerted in the male reproductive system, studies were also conducted to determine if the two PDE5 inhibitors also have an effect on fertility parameters such as sperm motility. The paper of Pomara et al in 2007 “Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men” assessed if Sildenafil (50 mg) and Tadalafil (20 mg) can acutely affect the seminal parameters in infertile, young patients [8]. 18 young men who were infertile were included in the study and were administered with a single dose of Sildenafil (50 mg) or Tadalafil (20 mg) and their semen samples were evaluated 1-2 hours post medication administration [8]. According to the results, Sildenafil was observed to have a progressive impact in the sperm motility. On the contrary, Tadalafil’s acute effect on sperm motility was the opposite of Sildenafil’s effect; Tadalafil was observed to significantly decrease sperm motility in the patients [8]. The authors concluded that both PDE5 inhibitors have acute but opposite effects on sperm motility of young infertile patients [8].

How Sildenafil Acts

Sildenafil Citrate, or what is commonly known as Viagra, works by exerting its nature as a PDE5 inhibitor in patients with erectile dysfunction. The mechanism of action of the drug is actually quite simple; Sildenafil enhances the effect of the cGMP (cyclic guanosine monophosphate) found in the penile corpus cavernosum and prevents its degradation by the PDE5 enzyme.

The PDE5 inhibitors such as Sildenafil Citrate are able to ameliorate the vasodilatory effect of cGMP/nitric oxide and their relaxation effect on the smooth muscles of the penis. As the blood vessels dilate and the smooth muscles relax, the erectile function is restored. Sildenafil Citrate makes sure that the cGMP does not get degraded in about 4 hours, so as long as there’s sexual stimulation, patients can expect their erectile response to improve upon their Sildenafil intake.

Dynafil Effects for Erectile Dysfunction

Dynafil contains Sildenafil Citrate and is considered one of the generic Viagra products in the market, so patients can expect the same erectile function-enhancing from the Dynafil products. The Sildenafil Citrate content of Dynafil is considered a highly potent agent for the treatment of impotence, so patients can experience a significant improvement in their erectile function on their every use of the drug unless their impotence cases are severe and need extra pharmacological/medical management procedures.

Dose Recommendation and Extent of Therapy

The present recommendation for Dynafil 50 mg/100mg is a single dose in a 24-hour period, as needed. Doctors may recommend 50 mg or 100 mg intake for the patients depending on their condition, and contingent to their response, the dose may be adjusted for the patients to experience optimal effects. Currently, there is no prescribed length of therapy for the patients with ED, as the PDE5 drugs’ effect (Sildenafil and the others) remain as transient and does not provide long-term improvement.

Adverse Effects and Warnings

According to the Dynafil leaflet, patients may experience side effects due to their use of the medication. The list of the noted side effects of the drug include (but are not limited to) the following: flushing, dizziness, headaches, stomach pain, GI discomfort, myalgia, increased heart rate, chest pain, low blood pressure, priapism (prolonged and painful erections), and nasal congestion [3].

Although rare, patients should still watch out for the following: tinnitus, ear pain, loss of vision, deafness, and anaphylaxis [3]. It is recommended that the patients consult their doctors immediately should these side effects appear, or should the drug cause worsening of the patients’ general health [3].

Drug Interactions

Other drugs can influence the effect of Dynafil or any Sildenafil-containing medication, so proper precaution should be taken before taking the drug. Also, Sildenafil products may influence the effectiveness of other medications, so it is required that patients should disclose all their medications fully to their physicians.

Dynafil information relates that the drug is affected by the following types of medications in all forms: antiviral HIV medicines, antiviral Hepatitis C medication, antifungal medicine, antacids, anti-ulcer medications, antibiotics, and nitrates [3]. Besides these medications, patients should not take Dynafil with alcoholic beverages in order to maximize the effectiveness of the medication.

Customer Reviews

There were no client feedbacks discovered for Dynafil, primarily because the drug is only locally available in South Africa. There was also no sale of the product discovered online, which makes the drug inaccessible by international patients.

Although the drug may be effective, its “no reviews” status can negatively impact the perception of the patients for Dynafil. There are factors why the drug did not have external reviews—the drug may just be unpopular or the drug may not be effective at all. But regardless of the reason, the fact that it did not have its online reviews may leave the customers doubting about the product’s effectiveness. However, generic Viagra products are generally effective, so buyers can still expect a good effect from Dynafil.

Price, Available Forms and Dosage

Although there was a price quote for Dynafil 50mg/100mg tablets, there is actually no online store selling the product. Most of the online sellers are selling Sildenafil products made by Indian makers, and Dynafil, being a product of South Africa, may have more restrictions than the Indian-made generics.

Dynafil Cost

Dynafil Cost

The price of 4 pieces of 50 mg tablets of Dynafil is $10.78, while the 100 mg variant costs $14.94 for the same 4 pieces. These prices for the product is not really the best price nor the most affordable price for generic Viagra products, but the price of Dynafil is still more affordable than the brand-name Viagra product.

Dynafil is only sold locally in South Africa and other countries where the company Pharma Dynamics exports to, so online buyers from the USA, Australia, and Canada are not able to purchase of the drug anywhere online. International buyers just have to look for other generic products sold online or they should just opt for their local options available.

Conclusion and Rating

Dynafil 50mg/100mg is a product of a company (Pharma Dynamics) which is owned by one of the major players in the pharmaceutical industry (Lupin Pharmaceuticals), which is also partnered with several multinational drug companies. Although the company integrity is implied, there are still many uncertainties surrounding the product efficacy due to the lack of reviews for the products. As for the rating, since Dynafil is manufactured by a reliable company, it can still be granted 3 points out of 5, because the product is still most likely an effective agent for erectile dysfunction. Dynafil is a recommendable product for impotence, but the product is not exactly readily available for clients who wish to purchase online.

Reference List

  1. https://en.wikipedia.org/wiki/PDE5_inhibitor
  2. http://home.intekom.com/pharm/pharmady/dynafil.html
  3. http://pharmadynamics.co.za/treat/mens-health/erectile-dysfunction-medication/pde-5-inhibitors/dynafil/
  4. http://pharmadynamics.co.za/who-we-are/overview/
  5. http://pharmadynamics.co.za/who-we-are/our-vision/
  6. https://www.researchgate.net/profile/Tyler_Hall3/publication/7347341_Non-arteritic_anterior_ischaemic_optic_neuropathy_and_the_treatment_of_erectile_dysfunction/links/5432a3ad0cf20c6211bc6880/Non-arteritic-anterior-ischaemic-optic-neuropathy-and-the-treatment-of-erectile-dysfunction.pdf
  7. http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2009.01375.x/full
  8. http://www.sciencedirect.com/science/article/pii/S0015028207000453
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